[An autopsy case of ovarian clear cell carcinoma 14 years after irradiation for uterine cervical carcinoma].

An autopsy case of a 46-year-old woman who developed right ovarian clear cell carcinoma 14 years after radiation treatment for uterine cervical cancer, is reported. The pathological characteristics of the clear cell carcinoma were solid, tubulo-cystic and papillary structures of clear, granular eosinophilic, hobnail , and vacuolated cells. A Review of the literature on ovarian clear cell carcinoma and multiple cancers is also presented.

Suppression of 7,12-dimethylbenz[a]anthracene-induced chromosome aberrations in rat bone marrow cells after treatment with Sudan III and related azo dyes.

Noninbred Long-Evans rats fed Sudan III at 24 hours before they were given an injection of 7,12-dimethylbenz[a]anthracene (DMBA) displayed prominently suppressed DMBA-induced chromosome aberrations (CA) in their bone marrow cells. Rats fed Sudan III simultaneously with the DMBA injection showed no suppressed CA effect. The suppressive effect of Sudan III on DMBA-induced CA paralleled the dose rate of Sudan III when given in the range between 1 and 10 mg Sudan III/kg body weight; higher doses produced no additional suppression.

A sex-transformation gene in Drosophila melanogaster.

A sex-transformation gene, tra-2OTF, of Drosophila melanogaster is described. The gene is an allele of tra-2 (transformer-2, 7--70+/-), acts only on XX individuals and transforms them into morphologically nearly normal but sterile males. Neither a male-specific lethal gene mle nor the male-killing maternally transmitted infectious SR-agent have any effect on the tra-2OTF transformed flies.