Publications by authors named "Fujian Chen"

Article Synopsis
  • GABAergic network activity is important for many bodily functions and is linked to different health issues, yet its effects on synaptic transmission in the entorhinal cortex-dentate gyrus (EC-DG) circuits are not well understood.
  • Through various advanced techniques, researchers found that activating GABA transporter 3 (GAT-3) in astrocytes raises calcium levels, which in turn enhances synaptic transmission; blocking GAT-3 has the opposite effect.
  • The study highlights the essential role of astrocytic GAT-3 in cognitive processes, as well as its influence on fear memory formation, suggesting potential targets for new treatments for cognitive disorders.
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Objectives: Maladaptive risky decision-making is a common pathological behavior among patients with various psychiatric disorders. Brain entropy, which measures the complexity of brain time series signals, provides a novel approach to assessing brain health. Despite its potential, the dynamics of brain entropy have seldom been explored.

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Background: This study aims to systematically evaluate the clinical efficacy and safety of acupuncture in combination with statin therapy compared to statin monotherapy for the treatment of dyslipidemia.

Methods: A comprehensive search for relevant randomized controlled trials assessing the clinical efficacy of acupuncture and statin combination in the treatment of dyslipidemia was conducted. Databases including PubMed, EMbase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disc, Wanfang database, and China Science and Technology Journal Database were searched up to October 27, 2023.

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Article Synopsis
  • A study was conducted to evaluate the safety of antiplatelet therapy in acute ischemic stroke (AIS) patients who have low platelet counts (thrombocytopenia), as there is limited research on this topic.
  • The research involved analyzing data from 169,423 AIS patients, ultimately focusing on 2,808 noncardioembolic patients with thrombocytopenia, comparing outcomes between those receiving antiplatelet therapy and those who did not.
  • Results showed that antiplatelet therapy did not significantly increase the risk of severe bleeding and was associated with better functional outcomes at discharge and a potential trend towards lower mortality after one year.
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Importance: The effect of argatroban in patients with acute ischemic stroke (AIS) and early neurological deterioration (END) is unknown.

Objective: To assess the efficacy of argatroban for END in AIS.

Design, Setting, And Participants: This open-label, blinded-end point, randomized clinical trial was conducted from April 4, 2020, through July 31, 2022.

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Background: The WHO grade and Ki-67 index are independent indices used to evaluate the malignant biological behavior of meningioma. This study aims to develop MRI-based machine learning models to predict the malignant biological behavior of meningioma from the perspective of the WHO grade, Ki-67 index, and their combination.

Methods: This multicenter, retrospective study included 313 meningioma patients, of which 70 were classified as high-grade (WHO II/III) and 243 as low-grade (WHO I).

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Developmental and epileptic encephalopathies (DEE) caused by heterozygous deleterious variants in Cut Like Homeobox2 () is rare. To the best of our knowledge the only variant associated with a phenotype in this gene is the missense variant c.1768G > A, p.

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Emotional abnormality in major depressive disorder (MDD) is generally regarded to be associated with functional dysregulation in the affective network (AN). The present study examined the changes in characteristics of AN connectivity of MDD patients before and after repetitive transcranial magnetic stimulation (rTMS) treatment over the left dorsolateral prefrontal cortex, and to further assess how these connectivity changes are linked to clinical characteristics of patients. Functional connectivity (FC) in the AN defined by placing seeds in the bilateral amygdale was calculated in 20 patients with MDD before and after rTMS, and in 20 healthy controls (CN).

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Objective: To analyze the effects of biofeedback combined with task-oriented training on hand function, Gesell's infant development scale score (Gesell) and balance ability in children with spastic cerebral palsy (SCP).

Methods: 66 children with SCP admitted to our hospital from January 2016 to June 2018 were randomly divided into the control group and the observation group. The control group ( =33) received conventional rehabilitation treatment, and the observation group ( =33) received biofeedback combined with task-oriented training based on the treatment of control group.

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Purpose: Night shift is associated with adverse physical and psychological health outcomes such as poor sleep quality and depressive symptoms. We aimed to compare sleep quality as well as depressive symptoms in nurses working night shifts to those working day shifts only and explore the association between sleep quality and depressive symptoms among nurses.

Patients And Methods: Eight hundred sixty-five nurses were enrolled in the current study.

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Background/aims: It has been questioned whether patients with unruptured intracranial aneurysms (IAs) are at a greater risk for the development of intracerebral hemorrhage (ICH) following thrombolytic therapy. We thus performed a meta-analysis to better quantify the risk of post-thrombolysis ICH in patients with acute ischemic stroke and incidental IAs.

Methods: We searched PubMed, Web of Science and EMBASE for studies assessing ICH risk in patients with acute ischemic stroke treated with thrombolysis, in relation to the presence of pretreatment IAs.

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