Publications by authors named "Fujia Chen"

Miniaturized spectrometers have significantly advanced real-time analytical capabilities in fields such as environmental monitoring, healthcare diagnostics, and industrial quality control by enabling precise on-site spectral analysis. However, achieving high sensitivity and spectral resolution within compact devices remains a significant challenge, particularly when detecting low-concentration analytes or subtle spectral variations critical for chemical and molecular analysis. This study introduces an innovative approach employing guided-mode resonance filters (GMRFs) to address these limitations.

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Conventional spectrometer designs necessitate a compromise between their resolution and sensitivity, especially as device and detector dimensions are scaled down. Here, we report on a miniaturizable spectrometer platform where light throughput onto the detector is instead enhanced as the resolution is increased. This planar, CMOS-compatible platform is based around metasurface encoders designed to exhibit photonic bound states in the continuum, where operational range can be altered or extended simply through adjusting geometric parameters.

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Numerous studies have reported that mono-(2-ethylhexyl) phthalate (MEHP) (bioactive metabolite of Di(2-ethylhexyl) phthalate) has inhibitory effects on Leydig cells. This study aims to prepare an oyster peptide-zinc complex (PEP-Zn) to alleviate MEHP-induced damage in Leydig cells. Zinc-binding peptides were obtained through the following processes: zinc-immobilized affinity chromatography (IMAC-Zn), liquid chromatography-mass spectrometry technology (LC-MS/MS) analysis, molecular docking, molecular dynamic simulation, and structural characterization.

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  • Nonreciprocity in acoustics is essential for various applications, but current methods using nonlinear media and moving fluids often face challenges like bulk size, high power needs, and integration difficulties.
  • The study introduces a framework that leverages asymmetric Peierls phases for designing nonreciprocal acoustic devices, controllable through active components, overcoming limitations of traditional approaches tied to Hermiticity.
  • Findings include an equivalence between transmission phases in isolators and the Peierls phase, and reveal that unique behaviors in gyrators and circulators are influenced by these phases, offering insights for compact, effective nonreciprocal devices.
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Miniaturized spectrometers have emerged as pivotal tools in numerous scientific and industrial applications, offering advantages such as portability, cost-effectiveness, and the capability for onsite analysis. Despite these significant benefits, miniaturized spectrometers face critical challenges, particularly in sensitivity. Reduced dimensions often lead to compromises in optical path length and component quality, which can diminish detection limits and limit their applications in areas such as low-light-level measurements.

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Background: With the demand for more effective and engaging teaching strategies in higher education, there is an imperative to blend traditional and innovative methods to optimize student learning outcomes. To address this educational need, this study sets out to design and evaluate a hybrid learning approach that integrates a flipped classroom based on working process systematization (termed "W + flipped classroom") teaching design with blended online and offline methods based on the BOPPPS (bridge-in, objective/outcome, preassessment, participatory learning, post assessment, summary, termed "B + BOPPPS") teaching model and explore its application effects in the field of biological separation engineering.

Methods: The undergraduate class of 2020 majoring in biomedical engineering from Huanghuai University was designated the control group (n = 74), while the undergraduate class of 2021 was chosen as the experimental group (n = 79).

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  • * Results showed significant improvements in semen volume, sperm density, motility, and viability, along with increased serum levels of hormones like FSH, LH, and testosterone in the RSV group, while inflammatory markers were lower.
  • * Proteomic analysis revealed that certain proteins related to spermatogenesis were up-regulated, and the steroid hormone synthesis pathway was identified as a key metabolic pathway influenced by resveratrol, suggesting its role in enhancing sperm quality.
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This study investigated the effects of compound probiotics (CP) on AFB-induced cytotoxicity in Sertoli TM4 cells. The L9 (3 × 3) orthogonal test was conducted to determine the optimal CP required for high AFB degradation in the artificial gastrointestinal fluid in vitro. The maximal AFB degradation rate was 40.

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Marek's disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek's disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry. The onset of MD lymphomas and other clinical diseases can be efficiently prevented by vaccination; these vaccines are heralded as the first demonstration of a successful vaccination strategy against a cancer. However, the persistent evolution of epidemic MDV strains towards greater virulence has recently resulted in frequent outbreaks of MD in vaccinated chicken flocks worldwide.

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  • Photonic Chern insulators have special edge states that are influenced by bulk band topology, allowing for engineered light properties.
  • Previous theories indicated that manipulating edge dispersion can slow down light while addressing limitations in traditional slow-light technology, like narrow bandwidth and susceptibility to imperfections.
  • This study presents the first experimental confirmation of these ideas, demonstrating that hybridizing edge states with nearly flat bands leads to light that is slowed down broadly and is resistant to backscattering, which could enhance slow-light device performance.
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  • Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer known to harm male reproductive health by causing testicular atrophy and reducing zinc levels in the testis.
  • A study developed an oyster peptide-zinc complex (OPZC) to counteract DEHP-induced reproductive damage in mice, demonstrating its stable and water-soluble structure.
  • The low dose of OPZC significantly improved reproductive health by normalizing hormone levels, testicular zinc and selenium content, and restoring gut microbiota balance, suggesting its potential protective effects on male reproductive health.
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  • * Researchers have successfully identified this phase in a three-dimensional photonic crystal, which shows surface and hinge Fermi arcs linked to its nonzero Chern number and a unique generalized Chern number.
  • * The study highlights a two-dimensional subsystem as a real Chern insulator, crucially differing from traditional Chern insulators, opening avenues for exploring their potential applications in material science.
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A facultative exoelectrogen, strain Clb-11, was isolated from polluted river water. This strain could generate electricity in microbial fuel cells (MFCs) with carboxymethyl cellulose (CMC) as the carbon source, and the maximum output power density was 12.17 ± 2.

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Dual- or multi-targeted EGFR inhibitors as single drugs can overcome EGFR inhibitor resistance and circumvent many disadvantages of combination therapy. In this work, fifteen 4-anilinoquinazoline derivatives bearing nitrogen mustard or hemi mustard moieties were designed and synthesized as dual EGFR-DNA targeting anticancer agents. Structures of target molecules were confirmed by H NMR, C NMR and HR-MS, and evaluated for their in vitro anti-proliferative activities using MTT assay.

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Plastic film capacitors are widely used in pulse and energy storage applications because of their high breakdown strength, high power density, long lifetime, and excellent self-healing properties. Nowadays, the energy storage density of commercial biaxially oriented polypropylene (BOPP) is limited by its low dielectric constant (~2.2).

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This study aimed to investigate the teaching effect of the blended BOPPPS based on an online and offline mixed teaching model ("B + BOPPPS") in the course of fermentation engineering in applied universities. The participants were 142 undergraduates majoring from the course of fermentation engineering in Food Science and Engineering in 2019 and 2020 in Huanghuai University, Zhumadian city, Henan province, China. The students in the control group (68 students) were taught in 2019, and the students in the experimental group (74 students) were taught in 2020.

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The hypothetical Weyl particles in high-energy physics have been discovered in three-dimensional crystals as collective quasiparticle excitations near two-fold degenerate Weyl points. Such momentum-space Weyl particles carry quantised chiral charges, which can be measured by counting the number of Fermi arcs emanating from the corresponding Weyl points. It is known that merging unit-charged Weyl particles can create new ones with more charges.

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  • The study investigates new plasma biomarkers for predicting gestational diabetes mellitus (GDM) by analyzing protein expression in placental tissues from pregnant women.
  • Researchers identified 123 differentially expressed proteins (DEPs) linked to various biological processes and focused on plasma levels of GAL-3BP, which were significantly higher in women with GDM compared to those with normal glucose tolerance.
  • The combination of GAL-3BP and triglycerides (TG) shows increased predictive power for diagnosing GDM early in pregnancy, with a higher accuracy than either marker alone.
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Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy. Thus, studies on the functions and biosynthetic pathways of rhamnose-containing compounds are in progress.

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Background: Maternal air pollutants exposure is associated with a number of adverse pregnancy outcomes, including recurrent spontaneous abortion (RSA). However, the underlying mechanisms are still unknown. The present study aimed to understand the mechanism of RSA and its relationship with air pollution exposure.

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In this study, we investigated the association between altered methylation in the maternal placenta and hyperglycaemia and explored the epigenetic mechanisms underlying gestational diabetes mellitus (GDM). Reduced representation bisulphite sequencing (RRBS) and RNA sequencing (RNA-seq) were performed on placental tissues obtained from women with GDM and healthy controls. Further, pyrosequencing, correlation analyses, and linear regression analyses were performed to valuate relationships between aberrantly methylated-differentially expressed genes and clinical parameters.

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The reconfigurable higher-order topological states are realized in valley photonic crystals with enhanced optical Kerr nonlinearity. The inversion symmetry of the designed valley photonic crystal is broken due to the difference in optical responses between adjacent elements rather than their geometry structures. Therefore, by constructing photonic crystals with distinct topological phases, valley-dependent topological states can be realized, and their reconfigurability is demonstrated based on the Kerr effect.

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Objectives: To screen the potential epigenetic biomarkers associated with endometriosis (EMS) and traditional Chinese medicine (TCM) syndrome EMS types.

Methods: A cohort of 99 participants comprising 42 EMS patients with cold coagulation blood stasis (CCBS) syndrome, 35 EMS patients with Qi stagnation blood stasis (QSBS) syndrome, and 22 women of childbearing age without EMS were recruited. Reduced representation bisulfite sequencing (RRBS) was used to establish the differential DNA methylation profiles in human peripheral blood samples obtained from four non-EMS and four EMS patients with CCBS or QSBS syndrome, respectively.

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This study focused on the optimization of ultrasound-assisted compound enzyme extraction for polysaccharides (RTPs) from by orthogonal experiment and response surface methodology, and then its extraction kinetics model and antihyperlipidemic activities were studied. The optimum extraction process was as follows: cellulase-1.0%, papain-1.

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The recently discovered non-Hermitian skin effect (NHSE) manifests the breakdown of current classification of topological phases in energy-nonconservative systems, and necessitates the introduction of non-Hermitian band topology. So far, all NHSE observations are based on one type of non-Hermitian band topology, in which the complex energy spectrum winds along a closed loop. As recently characterized along a synthetic dimension on a photonic platform, non-Hermitian band topology can exhibit almost arbitrary windings in momentum space, but their actual phenomena in real physical systems remain unclear.

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