Publications by authors named "Fuhrmann V"

Background: The α-Gal syndrome (AGS) is an emerging allergy to mammalian food caused by IgE-mediated reactions to the carbohydrate galactose-α-1,3-galactose (α-Gal). Mammalian food sources contain α-Gal, but the amount differs. The objective of this study was to investigate the allergenic potency of various foods of mammalian origin among AGS patients.

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  • The prevalence of liver diseases in ICU patients has risen to nearly 20%, leading to higher rates of morbidity and mortality.
  • Liver diseases in the ICU are categorized into primary hepatic dysfunctions (like acute liver failure) and secondary/acquired liver diseases (including cholestatic liver diseases and hypoxic liver injury).
  • Understanding the various causes and recognizing liver dysfunction early are crucial for effective diagnosis and treatment in critically ill patients.
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Objectives: Telephone instructions are commonly used to improve cardiopulmonary resuscitation (CPR) by lay bystanders. This usually implies an audio but no visual connection between the provider and the emergency medical telecommunicator. We aimed to investigate whether video-guided feedback via a camera drone enhances the quality of CPR.

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Background: COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a recurrent endemic disease affecting the whole world. Since November 2021, Omicron and its subvariants have dominated in the spread of the disease. In order to prevent severe courses of disease, vaccines are needed to boost and maintain antibody levels capable of neutralizing Omicron.

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This study compared the treatment outcomes of acute exacerbation of COPD (AECOPD) at an academic tertiary care emergency department before and during the COVID-19 pandemic. Analyzing data from 976 patients, our study showed a significant surge in overall respiratory therapy interventions amidst the noticeable decline in the total number of AECOPD cases during the pandemic. The marked increase in the utilization of non-invasive ventilation (NIV) was particularly important, soaring from 12% to 18% during the pandemic.

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  • Rescuers experience significant physical and psychological stress during CPR, especially in high-altitude environments where oxygen levels are lower, potentially impacting their performance.
  • A study with 20 experienced mountaineers showed that heart rates during CPR were generally higher at high altitude (3454 m) compared to baseline, indicating greater physical strain.
  • The findings suggest that while both scenarios result in exhaustion, the body may adapt by exhibiting a physiological reserve to cope with increased exertion in high-altitude situations.
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  • In acute-on-chronic liver failure (ACLF), how antibiotics like linezolid are dosed is difficult due to altered drug handling in the body.
  • A study compared the pharmacokinetics of linezolid in patients with ACLF undergoing continuous renal replacement therapy to those without liver issues.
  • Results showed that ACLF patients had much lower clearance rates for linezolid, meaning they are at risk of higher drug concentrations, suggesting that careful monitoring and potential dose adjustments are needed to avoid toxicity.
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  • GI bleeding is a common complication of direct oral anticoagulants (DOAC), requiring immediate assessment of medication history and coagulation status before emergency procedures.
  • Specific antidotes like idarucizumab and andexanet alfa are available for severe bleeding related to certain DOACs and are used after following proper emergency protocols.
  • Resumption of anticoagulation is essential after successful hemostasis, considering the balance between bleeding and thromboembolic risks.
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Background: Due to the COVID-19 pandemic, the first lockdown was implemented in Austria for almost 7 weeks. In contrast to many other countries, medical consultations were permitted, either by telemedicine or at doctors' offices. Nevertheless, restrictions related to this lockdown could possibly cause an increased risk of deterioration in health, especially in diabetes.

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Introduction: Hypoxic liver injury (HLI) is a frequent and life-threatening complication occurring in up to 10% of critically ill patients. Heart failure and age were previously identified as risk factors for occurrence of HLI. However, there is lack of data on incidence of HLI and its clinical implications on outcome in very old (≥90 years) patients.

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  • * The review emphasizes the beneficial effects of albumin dialysis on conditions like hepatic encephalopathy and pruritus, but notes that evidence does not strongly support improved overall survival, although short-term benefits have been observed.
  • * It recommends that albumin dialysis should be used primarily for patients eligible for transplantation and in centers experienced with severe liver disease, while awaiting more definitive large-scale studies.
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  • The study emphasizes the importance of accurately assessing risks in patients with Acute-on-Chronic Liver Failure (ACLF), as it is linked to high short-term mortality, particularly for liver transplant decisions.
  • The research found that patients with pulmonary impairment face significantly higher mortality rates, with those experiencing pulmonary failure having an alarming 83.7% mortality within 28 days.
  • Adjusting the CLIF-C ACLF score to account for the level of pulmonary impairment can improve the prediction of outcomes, suggesting that both pulmonary failure and mechanical ventilation are critical factors for evaluating the prognosis of ACLF patients.
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  • Acute liver failure (ALF) is a rare but serious condition with significant mortality rates, prompting an exploration of ICU professionals' approaches to its management.
  • A cross-sectional web-based survey of 204 ICU professionals across 50 countries revealed that many handle less than 25 ALF patients annually and have varying practices regarding treatment and outcomes.
  • The study showed substantial differences in ALF management based on factors like age, region, and hospital type, indicating a need for better education and research to standardize care.
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Background: Overcrowding decreases quality of care. Triage and patient administration are possible bottlenecks. We aimed to identify factors influencing door-to-triage- and triage-to-patient administration-time in a prospective observational study at a tertiary care center with 70,000 patients per year.

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Background: The COVID-19 pandemic led to widespread use of personal protection equipment (PPE), including filtering face piece (FFP) masks, throughout the world. PPE. Previous studies indicate that PPE impairs neurocognitive performance in healthcare workers.

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Background: Mucopolysaccharidoses (MPS) are a group of rare metabolic diseases characterized by a wide spectrum of symptoms including progressive condylar resorption.

Aim: The aim of this study was to quantify the severity of condylar involvement in MPS I individuals in comparison with a group of non-MPS individuals and to describe how condylar changes may vary among the different types of MPS.

Design: Fifty panoramic radiographs of MPS patients (13.

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  • Infection and sepsis significantly contribute to acute-on-chronic liver failure (ACLF), with voriconazole (VRC) being a recommended treatment; however, its effectiveness may be impacted by the altered pharmacokinetics (PK) in ACLF patients undergoing continuous renal replacement therapy (RRT).
  • A study of 15 patients (6 with ACLF) analyzed VRC PK using high-performance liquid chromatography and a dialysis pharmacometric model, finding no significant differences in clearance or volume distribution between ACLF and non-liver failure patients.
  • Monte-Carlo simulations indicated that the recommended VRC dose often resulted in suboptimal drug levels, suggesting that maintenance doses should be adjusted and therapeutic drug monitoring is critical
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Peanuts and tree nuts are two of the most common elicitors of immunoglobulin E (IgE)-mediated food allergy. Nut allergy is frequently associated with systemic reactions and can lead to potentially life-threatening respiratory and circulatory symptoms. Furthermore, nut allergy usually persists throughout life.

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  • ACLF is a serious complication of cirrhosis that affects liver transplantation outcomes, leading to significantly lower post-transplant survival rates compared to patients without ACLF.
  • Patients with ACLF have similar long-term graft function and comorbidities to those without ACLF, but experience notably worse quality of life, especially concerning mental health and physical well-being.
  • The study highlights the importance of monitoring and supporting the quality of life in ACLF patients after liver transplantation, despite comparable medical outcomes.
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Bleedings are frequent and clinically important complications in critically ill patients in the intensive care unit, and-depending on location and intensity-are associated with high morbidity and mortality. The clinical impact of different bleeding entities is affected by the location (e.g.

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