Selenium deficiency induces irritable bowel syndrome: Analysis of UK Biobank data and experimental studies in mice.

Irritable bowel syndrome (IBS) patients exhibit significantly lower levels of serum selenium (Se) compared to healthy controls. This study integrates a prospective cohort analysis and animal experiments to investigate Se deficiency as a potential risk factor for IBS. Using data from the UK Biobank, a longitudinal analysis was conducted to explore the associations between dietary Se intake and the risk of incident IBS.

Microplastics exposure induced and exacerbated the development of systemic lupus erythematosus in mice.

Environmental exposure may function as a contributing risk factor in the development of systemic lupus erythematosus (SLE). Recently, the global issue of microplastics (MPs) pollution has garnered increasing concern, yet its potential impact on SLE remains unexplored. This study seeks to elucidate the ramifications of MPs exposure on lupus manifestations in spontaneous lupus MRL/lpr mice and normal C57L/6 mice.

[Clinical significance of RT-PCR in detection of axillary lymph node micrometastases from breast cancer].

Background & Objective: Recently, it has been reported that reverse transcription polymerase chain reaction(RT-PCR) for the detection of related tumor marker genes expression in lymph nodes can be used to evaluate tumor metastasis and results in higher sensitivity. The objective of this study was to investigate the clinical significance of RT-PCR for detecting axillary lymph node metastases of breast cancer.

Methods: RT-PCR was used to examine the mRNA of MUC1 and keratin19 in axillary lymph nodes.