LncRNA TERRA in hybrid with DNA is a relevant biomarker for monitoring patients with meningioma.

Telomeric repeat-containing RNAs (TERRAs) are expressed from subtelomeric regions, as long non-coding RNAs responsible for maintaining telomere length and stabilizing the genome. After TERRA is transcribed (f-TERRA) from subtelomere regions, it hybridizes (h-TERRA) into telomeres and intergenic regions to maintain genome and telomere stability. Here, we separately determine changes in two TERRA fractions, f-TERRA and h-TERRA levels in relation to telomere length (TL) in first time meningioma patients with preoperative and postoperative comparisons with the control group.

Cross cultural adaptation and psychometric evaluation of the Turkish PedsQL Brain Tumor Module: Assessing health-related quality of life in children with brain tumors.

Background: Brain tumors are the most common type of pediatric cancer, significantly impacting children's health-related quality of life (HRQoL). This study aimed to adapt the PedsQL-BTM to Turkish culture and evaluate its psychometric properties, including reliability, validity, and cross-cultural consistency.

Method: A total of 108 children with brain tumors (mean age: 9.

Subgroup analysis of elderly patients (≥60 years) with diffuse large B-cell lymphoma in the phase 3 POLARIX study.

In the phase 3 POLARIX study, polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) improved progression-free survival (PFS) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL). This post hoc subgroup analysis of POLARIX evaluated the efficacy and safety of Pola-R-CHP versus R-CHOP in elderly patients ≥60, ≥65, ≥70, and ≥75 years. As of June 15, 2022 (median follow-up 40 months), 629 patients ≥60 years were included (Pola-R-CHP, n = 311; R-CHOP, n = 318).

Three locally invasive infantile fibrosarcoma cases treated with larotrectinib.

Background: Infantile fibrosarcoma is a rapidly growing soft tissue tumor, often managed by surgical resection, with chemotherapy and radiotherapy as additional options. Due to the high local aggressiveness and surgical morbidity, targeted therapies like larotrectinib can enhance quality of life and preserve organs, particularly in limb-threatening cases. Here, we present three cases where larotrectinib prevented mutilating surgeries.

The relationship between motor competence and executive function as influenced by age, sex, and family socio-economic status.

Introduction: Motor Competence (MC) plays a fundamental role in physical, cognitive, and social development, while executive function (EF) is a key factor influencing MC. The primary objective of this study was to compare MC across three age groups (children, adolescents, and young adults), sex, and socio-economic status (SES). The main aim was to investigate the relationship between MC and EF and to determine whether age, sex, and SES could modify this relationship.

Glycemic Control in Obese Type 2 Diabetic Patients Treated with Laparoscopic Sleeve Gastrectomy and Transit Bipartition.

BACKGROUND Type 2 diabetes mellitus (T2DM) and obesity are significant health challenges linked to increased morbidity and mortality. Laparoscopic sleeve gastrectomy with transit bipartition (LSG+TB) has shown promise in improving glycemic control. This study aimed to evaluate the outcomes of obese patients with T2DM treated with LSG+TB, focusing on variations in surgical techniques.

Biomonitoring and Source Identification of Potentially Toxic Metals in Different Plant Species in Mountain Ulus, Turkey.

This study investigated the Cd, Fe, Mn, Ni, Pb, and Zn levels in Mt. Ulus plants, analysed their distribution characteristics and determined their origin using Positive Matrix Factorization (PMF) modelling. Using the multi-point sampling method, 28 plants were sampled from Mt.

Oral selective estrogen receptor degraders (SERDs) in hormone receptor-positive HER2-negative metastatic breast cancer after progression with CDK4/6 inhibitors.

Introduction: Hormone receptor-positive (HR+), HER2-negative metastatic breast cancer (mBC) remains a prevalent and challenging disease. Endocrine therapy (ET) combined with CDK4/6 inhibitors is the first-line standard of care, yet resistance mechanisms, including ESR1 mutations, drive disease progression. Novel oral selective estrogen receptor degraders (SERDs) have emerged as promising therapeutic agents after progression with CDK4/6 inhibitors secondary to ESR1 mutations.

Derivation of functional neurons from induced pluripotent stem cells using a simple neuromesodermal progenitor generation and rapid spinal cord neuron differentiation process.

To generate spinal cord neurons from pluripotent stem cells via neuromesodermal progenitors (NMPs) is not only an important step for regenerative purposes but also required for human developmental research. This study describes a protocol to obtain spinal cord neurons in culture using induced pluripotent stem-cell-derived NMPs. The protocol starts with a 3D culture of NMPs and continues with the transfer of 3D NMPs to monolayer culture in which retinoic acid and sonic hedgehog pathways were triggered sequentially.

Short and Long-Term Outcomes of Liver Transplantation in Pediatric Patients With Inborn Errors of Metabolism: A Single-Center Study.

Background: Inborn errors of metabolism (IEMs) are inherited diseases causing significant morbidity and mortality, particularly in childhood. Liver transplantation (LT) can be curative or partially effective for these diseases. LT for IEMs has increased, making IEMs the second most common reason for pediatric LT after biliary atresia.

Evaluation of and gene expression in male infertility patients with low or high sperm DNA fragmentation.

Objective: The transition nuclear protein 1 () gene is a member of the TNP family and is abundantly expressed during spermatogenesis. Protamine 1 (), another sperm nuclear protein, is abundant in many species. The present study aimed to evaluate transition nuclear protein 1 () and protamine 1 () gene expression in infertile male patients with low and high sperm DNA fragmentation (SDF).

Long-Term Outcomes in Crosslinking Therapy for Patients with Progressive Keratoconus.

To investigate the mid- and long-term postoperative follow-up results of corneal crosslinking (CXL) treatment (using epi-on and epi-off techniques) in progressive keratoconus. This was a retrospective single center study conducted between October 2013 and July 2020. Patients who received CXL treatment with a diagnosis of progressive keratoconus were included in the study.

TGFβ links EBV to multisystem inflammatory syndrome in children.

In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion and systemic hyperinflammation. The pathogenesis of MIS-C remains largely unknown.

Anti-cancer effects of boron derivatives on non-small cell lung cancer.

Lung cancer is the most frequently diagnosed cancer globally, with 2.5 million new cases representing 12.4 % of the total number of new cases.

Noninfectious Uveitis in Pediatric Rheumatology: Long-term Follow-up at Tertiary Centers.

Objectives: Our study aimed to identify potential predictors for additional systemic involvement in patients with noninfectious uveitis, specifically focusing on their demographic, etiological, clinical, and laboratory data features from the pediatric rheumatology perspective.

Methods: Patients with noninfectious uveitis before the age of 18 years and followed up for at least 3 months in 2 tertiary centers of pediatric rheumatology and ophthalmology departments were included in the study. Demographics, etiology, clinical features, laboratory data, and treatments administered were evaluated and compared based on the etiology (idiopathic and systemic disease-related uveitis [SD-U]) and the use of biologic disease-modifying antirheumatic drugs.

NETosis: A key player in autoimmunity, COVID-19, and long COVID.

NETosis, the process through which neutrophils release neutrophil extracellular traps (NETs), has emerged as a crucial mechanism in host defense and the pathogenesis of autoimmune responses. During the SARS-CoV-2 pandemic, this process received significant attention due to the central role of neutrophil recruitment and activation in infection control. However, elevated neutrophil levels and dysregulated NET formation have been linked to coagulopathy and endothelial damage, correlating with disease severity and poor prognosis in COVID-19.

Primary cardiac lymphoma presenting with wide QRS tachycardia: a case report.

Background: Lymphomas, which originate from the haematopoietic system, are seldom found in the heart due to the absence of a lymphoid system. Primary cardiac lymphoma is quite rare. Cardiac lymphomas can present with dyspnoea, heart failure, pericardial effusion, and arrhythmia.

Olfactory Effects of Chemotherapy Combined with Bevacizumab on Advanced-Stage Colorectal Cancer Patients: Chemotherapy and Olfaction.

Impaired olfaction negatively impacts nutrition and appetite, particularly gaining more significance in cancer patients for whom nutrition and calorie intake are crucial. In our study, we aimed to investigate the effects of advanced-stage colorectal cancer treatment on olfactory functions. Fourteen patients (78.

Cyclophosphamide treatment with a comparison in both pediatric rheumatology and pediatric nephrology practices.

Background: Cyclophosphamide (CYC) is an inactive alkylating agent that transforms the alkyl radicals into other molecules and is used in combination with systemic corticosteroids in the treatment of many childhood rheumatic diseases, such as systemic lupus erythematosus (SLE), and ANCA-associated vasculitis (AAV). In recent years, rituximab (RTX), a B-cell-targeting anti-CD20 monoclonal antibody, has emerged as a new alternative treatment modality over CYC for induction therapy of childhood-onset rheumatic diseases. Clinicians adopt different practices for using CYC particularly in relation to indications, posology, pre-treatment laboratory work-up, post-treatment follow-up, and screening pre- and post-treatment vaccination status.

Structure and function relationships of mucociliary clearance in human and rat airways.

Mucociliary clearance is a vital defense mechanism of the human airways, protecting against harmful particles and infections. When this process fails, it contributes to respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. While advances in single-cell transcriptomics have revealed the complexity of airway composition, much of what we know about how airway structure impacts clearance relies on animal studies.

Does voıce therapy after endolarygeal mıcrosurgery contrıbute to the treatment of vocal fold polyp?

Unlabelled: İntroduction: The aim of this study was to assess the contribution of voice therapy to management of patients following surgery for vocal fold polyps.

Methods: In this prospective study, two groups were created by randomizing patients diagnosed with vocal fold polyps. Group 1 received only phonosurgery, and Group 2 received phonosurgery followed by voice therapy.

Predictors of Illness Behavior in Turkish Women with Cardiovascular Disease: The Role of Health Anxiety and Cyberchondria.

This study aimed to determine whether illness behavior in women with cardiovascular disease varied based on specific sociodemographic characteristics and to explore the effect of health anxiety and cyberchondria on the level of illness behavior. A descriptive and cross-sectional study was conducted with 255 women with cardiovascular disease who applied to the cardiology outpatient clinic of a state hospital in Turkey between June and August 2023. Data were collected using personal information forms, such as the Scale for the Assessment of Illness Behavior, Health Anxiety Scale, and Cyberchondria Severity Scale.