Estrogen Alleviates Oxidative Bowel Injury and Neuroinflammation in Necrotizing Enterocolitis.

Introduction: High mortality and morbidity of neonates with necrotizing enterocolitis (NEC) necessitates the investigation of novel therapies to improve outcomes. It was aimed to elucidate the potential therapeutic effect of estrogen receptor agonists on NEC-induced intestinal and brain injury in rats.

Methods: Sprague-Dawley pups of both sexes were separated from their mothers at postnatal 5 d.

The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer.

Despite advances in cancer treatment, breast cancer (BC) remains one of the most common cancers affecting women worldwide. This study aimed to determine serum circFBXW7, circABCB10, and circ0103552 levels and compare BC patients and healthy controls to investigate their roles in the molecular mechanism of BC and the significance of these circRNAs in BC diagnosis. The study group consisted of 92 patients with BC and 31 healthy controls.

Armoring chimeric antigen receptor (CAR) T cells as micropharmacies for cancer therapy.

Chimeric antigen receptor (CAR)-T-cell therapy has emerged as a powerful weapon in the fight against cancer. However, its efficacy is often hindered by challenges such as limited tumor penetration, antigen escape, and immune suppression within the tumor microenvironment. This review explores the potential of armored CAR-T cells, or 'micropharmacies', in overcoming these obstacles and enhancing the therapeutic outcomes of adoptive T-cell (ATC) therapy.

Surgical outcome of meningomyelocele and short-term prognostic factors: A retrospective cohort study.

Introduction: Meningomyelocele is the most common congenital anomaly. It is associated with significant complications and can result in morbidity and mortality. The present study aims to identify short-term prognostic markers by investigating the characteristics of patients with meningomyelocele during hospitalization.

Investigation of metabolite profiles of kidney tissues in rats treated with favipiravir drug: An NMR-based metabolomics study.

In response to the urgent need for effective treatments during the rapid spread and high mortality rate of COVID-19, existing drugs were repurposed for potential antiviral effects, including favipiravir, originally designed as an RNA-dependent RNA polymerase inhibitor for influenza. Despite limited antiviral effectiveness against COVID-19, favipiravir has been reported to cause several adverse drug events (ADEs) in the body. Recent studies have shown that favipiravir can damage various tissues in rats.

Prognostic value of the HALP score in metastatic castration-resistant prostate cancer: an analysis combined with time to castration resistance.

Objective: The aim of our study was to assess the impact of the combination of HALP score with TTCR score on OS and PFS in PC patients who developed castration resistance.

Patients And Methods: The study enrolled 152 patients with metastatic disease who had received either ARTAs or docetaxel as first-line treatment. The median cut-off was 30.

Anorectal manometry and urodynamics in children with spina bifida: can we predict the colonic dysmotility from bladder dysfunction?

Introduction: Spina bifida is a condition that impacts the development of the neural tube leading to urological and gastrointestinal symptoms. Both systems are influenced together due to their shared innervation and embryological origin. Despite its impact on health and well-being there has been limited research on the relationship between manometry results and urodynamic tests, in this patient population.

The Influence of Cancer Type on Stroke Incidence: A Retrospective Study.

Background: The aim of this study is to examine the hematological and biochemical variables in patients diagnosed with cancer-related stroke who have different types of cancer and to evaluate the effects of these variables.

Methods: This retrospective study was conducted at a tertiary hospital stroke center and included 153 patients diagnosed with cancer-related stroke. Comprehensive etiological investigations were performed, and patients were classified according to the Trial of Org 101072 in Acute Stroke Treatment (TOAST) classification.

Growth Trajectories of Joint Attention and Play as Predictors for Language in Young Children at Elevated Likelihood for Autism.

This longitudinal study investigated the predictive value of initial level and growth rate of joint attention and play from 10 to 24 months for language abilities of 24-month-old toddlers at elevated likelihood (EL) for autism. (Semi-)structured assessments were used to measure all variables at different timepoints prospectively in younger siblings of children with autism (siblings, n = 48) and children born before 30 gestational weeks (preterms, n = 49). A positive association was found between initial level of play at 10 months and expressive language at 24 months in siblings, but not in preterms.

Changes in the Volume and Diameter of Benign Thyroid Nodules: A 10-Year Follow-Up Study.

The incidence of asymptomatic thyroid nodules has risen enormously, with > 90% being benign. Despite limited long-term data, significant nodule growth (SNG) is common. Guidelines recommend cytology reevaluation if SNG occurs.

Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach.

Significance: Assessment of pain and its clinical diagnosis rely on subjective methods which become even more complicated under analgesic drug administrations.

Aim: We aim to propose a deep learning (DL)-based transfer learning (TL) methodology for objective classification of functional near-infrared spectroscopy (fNIRS)-derived cortical oxygenated hemoglobin responses to painful and non-painful stimuli presented under different timings post-analgesic and placebo drug administration.

Approach: A publicly available fNIRS dataset obtained during painful/non-painful stimuli was used.

Cross-Cultural Adaptation and Clinical Validation of TIME Criteria to Detect Potentially Inappropriate Medication Use in Older Adults: Methodological Report from the TIME International Study Group.

Background: Various explicit screening tools, developed mostly in central Europe and the USA, assist clinicians in optimizing medication use for older adults. The Turkish Inappropriate Medication use in oldEr adults (TIME) criteria set, primarily based on the STOPP/START criteria set, is a current explicit tool originally developed for Eastern Europe and subsequently validated for broader use in Central European settings. Reviewed every three months to align with the latest scientific literature, it is one of the most up-to-date tools available.

Sericin-Enriched Rabbit Semen Preservation: Implications for Short-Term Storage Quality and Fertility at 4 or 15 °C.

The influence of sericin supplementation and chilling temperatures (4 and 15 °C) on the short-term storage quality and fertility of rabbit semen was assessed over 72 h of storage. In experiment 1, pooled semen (five replications) was diluted to a concentration of 50 M mL, and assigned to control, 0.1%, and 0.

Childhood Traumas, Attachment Styles and Related Clinical Factors in Opioid Use Disorder.

Introduction: The study aims to compare childhood traumas, attachment styles, impulsivity, and quality of life of Opioid Use Disorder (OUD) patients in remission with healthy controls and to reveal the relationships between these parameters.

Methods: The study included one hundred patients diagnosed with OUD and one hundred healthy volunteers. Sociodemographic data form, Structured Clinical Interview for DSM-5 Disorders Clinician Version, Childhood Trauma Questionnaire, Relationship Scales Questionnaire, Barratt Impulsivity Scale-11, World Health Organization Quality of Life Scale Brief Version and Substance Craving Scale were administered.

Affective modulation of emotional reactivity in euthymic patients with bipolar disorder.

Background: Affective modulation of startle reflex (AMSR) is a widely used experimental tool for assessing emotional reactivity. Previous research has shown inconsistent findings of emotional reactivity in amplitude in bipolar patients (BP). This study examined emotional reactivity (ER) in euthymic BP compared to healthy controls using both subjective and objective measures.

Communicable Disease Risk Awareness and Prevention: A Study on University Students in the Context of Social Support and Disaster Risk.

Objective: Factors such as the risk of the spread of infectious diseases, global health crises, and disasters are among the major health and security challenges facing societies. Informed protective measures and effective risk awareness are necessary to cope with these challenges. As young adults, university students represent a significant segment of society, making studies conducted on this group critical for implementing effective measures against infectious disease risks.

Does COVID-19 reduce anti-Mullerian hormone levels in women of reproductive age in late periods of infection?

Objective: The question of whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection influences ovarian function and oocyte quality has arisen as angiotensin converting enzyme-2 receptors, which facilitates viral infection, are found on reproductive system tissues, including the vagina, placenta, uterus, and ovaries. The primary objective of this prospective study was to evaluate the impact of SARS-CoV-2, on ovarian function, with a focus on anti-Mullerian hormone (AMH) and acute phase reactant levels in patients well after recovery from coronavirus disease-2019 (COVID-19).

Material And Methods: This prospective cohort study was conducted in the department of obstetrics and gynecology at a single center between October 2020 and June 2021.

Self-assembled peptide-based nanofibers for cardiovascular tissue regeneration.

Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use of nanomaterials, particularly nanofiber-based scaffolds combined with biomolecular cues like peptides, has significantly improved the compatibility and efficacy of the scaffolds for cardiac tissue regeneration.

PRISMA-7 is a predictor of intensive care unit admission and mortality in older patients in an emergency department.

Aim: To compare the performance of the Programme of Research on the Integration of Services for the Maintenance of Autonomy (PRISMA-7), which is used to assess the frailty of older patients visiting emergency departments, with the quick Sepsis Related Organ Failure Assessment (qSOFA) and Emergency Severity Index (ESI) in terms of 28-day mortality and intensive care unit (ICU) admission.

Methods: This study was prospective and observational. All patients above the age of 65 who were admitted to the Sivas Republic University Medical Faculty Hospital from March 1 to April 30 in the year 2024 were included in the study.

The role of habitat preference and feeding strategy on exposure to microplastic pollution in freshwater fish species.

Microplastic (MP) pollution has been observed in a variety of ecosystems, but there is a limited number of studies on reservoir ecosystems. The aim of this study was to determine the levels of MP contamination in sediment, water and commercially important fish species (Cyprinus carpio, Perca fluviatilis, Atherina boyeri and Sander lucioperca) collected from the Yamula Reservoir in Türkiye. Water samples were collectes at five stations.

Do Intact Collateral Ligaments Play a Role in the Overall Clinical and Radiological Results of Rotating Hinge Knee Arthroplasties?

Background: Rotating hinge knee arthroplasty (RHKA) implants are often utilized as a salvage procedure in cases where bone stock is compromised. The aim of this retrospective study was to investigate whether residual collateral ligament integrity affects functional and radiographic outcomes in patients undergoing revision surgery with RHKA.

Methods: Patients treated with RHKA between 2011 and 2021 were eligible.

Modulation of physical exercise intensity in motor-cognitive training of adults using the SKILLCOURT technology.

Motor-cognitive training and exergaming often only reach low-to-medium intensities that limits their training efficiency. This study evaluated the physiological profile of different exercises on a novel motor-cognitive training technology designed to cover a broad range of exercise intensities. Twenty-six healthy trained adults (17 males, 23.

Verbascum gimgimense an Endemic Turkish Plant: Evaluation of In Vitro Anticancer, Antioxidant, Enzyme Inhibitory Activities, and Phytochemical Profile.

The Verbascum genus has gained significant attention in the pharmaceutical field, particularly in recent years, due to its valuable medicinal properties, which are well-recognized in complementary and alternative medicine. Certain species within this genus contain essential compounds and exhibit a wide range of therapeutic activities. In this study, the ethanolic extract of Verbascum gimgimense (VG) was analyzed for its cytotoxic, apoptotic, antioxidant, and enzyme inhibitory properties, as well as its phenolic and lipophilic compounds.