Publications by authors named "Fuerst S"

Vulvar cancer incidence numbers have been steadily rising over the past decades. In particular, the number of young patients with vulvar cancer has recently increased. Therefore, the need to identify new prognostic factors and, in addition, therapeutic options for vulvar carcinoma is more apparent.

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  • * In a study of 306 patients, pelvic LAE was performed in 35.6% of cases, with pelvic nodal involvement found in 18.5%, primarily in patients with more advanced nodal status (≥pN2a).
  • * Adjuvant RT was given to 64.4% of the patients, but only half of those with pelvic nodal involvement received it, highlighting a significant risk of recurrence, particularly in cases with higher nodal status, while suggesting that
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Background: The impact of adjuvant radiotherapy (RT) to the vulva with regard to prognosis and local recurrence in patients with vulvar squamous cell cancer (VSCC) is poorly described.

Patients And Methods: In the AGO-CaRE-1 study 1618 patients with primary VSCC FIGO stage ≥ IB, treated between 1998-2008, were documented. In this retrospective subanalysis, 360 patients were included based on the following criteria: nodal involvement (pN+), known RT treatment and known radiation fields.

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Vulvar cancer incidence numbers have been rising steadily over the past decades. Especially the number of young patients with vulvar cancer increased recently. Therefore, the need to identify new prognostic factors for vulvar carcinoma is more apparent.

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Background: As the population at risk for pelvic nodal involvement remains poorly described, the role of pelvic lymphadenectomy (LAE) in vulvar squamous cell cancer (VSCC) has been a matter of discussion for decades.

Methods: In the AGO-CaRE-1 study, 1618 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB or higher primary VSCC treated at 29 centers in Germany between 1998 and 2008 were documented. In this analysis, only patients with pelvic LAE (n = 70) were analyzed with regard to prognosis and correlation between inguinal and pelvic lymph node involvement.

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Background: Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.

Methods: This is an analysis of the AGO-CaRE-1 cohort.

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Background: There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma-a human papillomavirus-dependent pathway characterized by p16 overexpression and a human papillomavirus-independent pathway linked to lichen sclerosus, characterized by TP53 mutation. A correlation of human papillomavirus dependency with a favorable prognosis has been proposed.

Objective: The objective of the study was to further understand the role of human papillomavirus and p53 status in vulvar squamous cell carcinoma and characterize its clinical relevance.

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  • The 2015 updated German guidelines on pelvic lymphadenectomy (LAE) for vulvar cancer patients recommend surgical lymph node staging for those at higher risk, but defining this risk is still unclear.
  • Two German patient populations have been analyzed to study the impact of lymph node metastasis, one including 1,618 patients and another 514 patients, with a small number undergoing pelvic LAE.
  • Findings indicate that about 80% of patients who had pelvic LAE were also positive for inguinal lymph nodes, and pelvic lymph node staging may not be necessary for many node-positive patients, especially those with low-grade disease.
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  • The study investigates the expression of LDOC1, a protein linked to patient survival in various cancers, specifically within vulvar carcinoma and its immune environment.
  • High levels of LDOC1 were found in vulvar cancer cells, with cytoplasmic expression correlating to shorter overall survival, while nuclear expression negatively impacted disease-free survival.
  • The NF-κB inhibitor C-DIM 12 reduced cell viability in one vulvar cancer cell line (A431) but not in another (SW 954), indicating potential for targeted therapies influenced by LDOC1 levels.
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Ascorbate oxidases are an enzyme group that has not been explored to a large extent. So far, mainly ascorbate oxidases from plants and only a few from fungi have been described. Although ascorbate oxidases belong to the well-studied enzyme family of multi-copper oxidases, their function is still unclear.

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New international enterprises that are referred to as Born Globals have become the subject of research due to the success of their global operations, despite their early internationalization and limited resources. Given the importance of analyzing the characteristics that contribute to the success of Born Globals, our study examines the influence of international orientation on export performance. Additionally, we consider internal and external drivers for early and accelerated internationalization such as the Born Global's innovative capacity, the dynamism of the market and the favorability of the environment.

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Aim Of The Study: A tumour-free pathological resection margin of ≥8 mm is considered state-of-the-art. Available evidence is based on heterogeneous cohorts. This study was designed to clarify the relevance of the resection margin for loco-regional control in vulvar cancer.

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Background: Women with node-positive vulvar cancer have a high risk for disease recurrence. Indication criteria for adjuvant radiotherapy are controversial. This study was designed to further understand the role of adjuvant therapy in node-positive disease.

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Although there is much evidence to substantiate the view that tumor necrosis factor (TNF) plays a pivotal role in the pathogenesis of multiple organ injury subsequent to intestinal ischemia/reperfusion (I/R), it is still unclear whether TNF is involved in triggering the release of other inflammatory mediators in this condition. The current study was designed to determine the potential effects of TNF blockade, by means of monoclonal antibody (TNF MoAb) treatment, on plasma interleukin 6 (IL-6) in rats after acute intestinal I/R injury. Anesthetized rats underwent 75-min occlusion of superior mesenteric artery followed by 6 hr of reperfusion.

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