Inflammatory and bone regulators expression in murine macrophages under exposure of commercial and experimental mineral trioxide aggregate.

Background: Mineral trioxide aggregate (MTA) has been used in a variety of surgical and non-surgical endodontic applications. The aim of this study was to evaluate the gene expression and protein production of TNF-α, IL-1β and IL-6, as well as the gene expression of RANKL and OPG using both commercial and experimental MTA in macrophage cell cultures.

Methods: Peritoneal macrophage cell culture was performed.