Synthesis and Anti-Inflammatory Evaluation of Novel Hybrids of 7-Oxodehydroabietic Acid Bearing a 1,2,3-Triazole Moiety.

To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of H NMR, C NMR, and ESI-HRMS. All the compounds were evaluated for their anti-inflammatory activity towards BV2 cell lines using L-NMMA (IC = 42.

Three new xanthones and other anti-inflammatory components from the aerial parts of Hypericum beanii.

Hypericum beanii, a traditional folk medicine plant, has been employed in treating various inflammation-related diseases. In this study, three new prenylated xanthones, named beanigenin A (1), beanigenin B (2), and beanigenin C (3), along with twenty-five known compounds (4-28), were isolated from the aerial parts of H. beanii.

Norlignans and Phenolics from and Their Neuroprotection Against Glutamate-Induced Oxidative Injury in SH-SY5Y Cells.

The herb (Lour.) Ktze is widely distributed in southern and southwestern China. The genus and its primary chemical constituents exhibit remarkable antidepressant activities.

Novel Iridoid Derivatives Isolated from the Roots of with Potential Anti-Renal Fibrosis Activity In Vitro.

Scabrol B and Scabrol C, two newly identified iridoid derivatives ( and ) and six known compounds (-), were extracted from the roots of . The structures of these derivatives, including their absolute configurations, were elucidated via comprehensive NMR analysis, chemical derivatization, and quantum chemical ECD calculations. All isolated compounds were evaluated for their anti-renal fibrosis activity.

Aromatic Abietane-Type Diterpenoids from the Roots of Salvia prattii and their Protective Activity Against Alcoholic Liver Disease.

Eighteen aromatic abietane-type diterpenes, including three previously unreported compounds, Salkanoids A-C (1-3), were isolated from the roots of Salvia prattii. Their stuctures were extensively elucidated using 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS) data, and ECD calculation. Among these, compounds 1, 6 and 7 belong to a class of diterpenes featuring a [5, 5]-oxaspirolactones moiety, a rare structure isolated from the Salvia plants.

Anti-Inflammatory Effect of Xanthones from on Macrophage RAW 264.7 Cells through Reduced NO Production and TNF-, IL-1, IL-6, and COX-2 Expression.

N. Robson, a perennial upright herb, predominantly inhabits temperate regions. This species has been utilized for the treatment of various inflammation-related diseases.

Anti-Inflammatory Peroxidized Chlorahololide-Type Dimers Are Artifacts of Shizukaol-Type Dimers: From Phenomena Discovery and Confirmation to Potential Underlying Mechanism.

In our research on naturally occurring sesquiterpenes, eight shizukaol-type dimers, one chlorahololide-type dimer, and one sarcanolide-type dimer were isolated from the roots of As the project was implemented, we accidentally discovered that shizukaol-type dimers can be converted into peroxidized chlorahololide-type dimers. This potential change was discovered after simulations of the changes in corresponding shizukaols showed that three peroxide products were generated (), indicating that peroxidation reactions occurred. HPLC-HR-MS analysis results obtained for the shizukaol derivatives further demonstrate that the reaction occurred, and the type of substituent of small organic ester moieties at positions C-15' and C-13' of unit B were not decisively related to the reaction.

Anti-Hyperuricemic Effects of Extracts from (Sweet) Nakai Fruits on Hyperuricemic Rats.

(Sweet) Nakai () fruit has medicinal and food applications and exhibits beneficial pharmacological properties. This study aimed to explore the hypouricemic effect of fruit extracts on hyperuricemic rats and uncover potential protective mechanisms. The rats were given hypoxanthine (HX, 100 mg/kg) and potassium oxonate (PO, 300 mg/kg) for 14 days to induce hyperuricemia.

Secondary metabolites from the Actinomadura sp. and their cytotoxic activity.

Actinomadura sp., which is usually found in muddy habitats, produces various secondary metabolites with biological activities. In this study, five new compounds named formosensin A (1), formosensin B (2), oxanthroquinone-3-O-α-d-mannose (8), oxanthromicin A (9), and oxanthromicin B (10) were isolated from the culture of Actinomadura sp.

The intramolecular S2 reaction tautomeric ent-Kauranoids isolated from the aerial parts of Isodon amethystoides.

As our ongoing searching for the bioactive natural terpenoids, nine ent-kauranoids (1-9), including three previously undescribed ones (1, 2, and 9), were isolated from the aerial parts of Isodon amethystoides. Their structures were elucidated on the basis of spectroscopic data analysis, including NMR, MS, and ECD. Compounds 1 and 2 were a pair of tautomeric compounds, which was confirmed by the HPLC analysis and low temperature NMR testing.

Cytotoxic and anti-inflammatory constituents from roots of Hypericum beanii and the antitumor potential under the view of cancer-related inflammation.

Hypericum beanii, a traditional folk medicine plant, has been employed in the treatment of various inflammation-related diseases and has demonstrated promising potential as an herbal remedy for cancer. In this study, we isolated 29 compounds from the roots of H. beanii.

A Scalable and Metal-Free Synthesis of Indazoles from 2-Aminophenones and In Situ Generated De-Boc-Protected -Mesitylsulfonyl Hydroxylamine Derivatives.

A one-pot metal-free protocol to access indazoles from easily available 2-aminophenones and hydroxylamine derivatives has been achieved. The reaction is operationally simple, mild, and insensitive to air and moisture. A broad range of indazoles were prepared in good to excellent yield (up to 97% yield), and the reaction displayed a broad functional group tolerance.

Antibacterial Activity of Turcz Extract Against Bacteria Associated with Upper Respiratory Tract Infections.

Purpose: The drug resistance of and has become more and more serious, and it is urgent to seek new antibacterial drugs. In this study, Turcz. extracts were tested for its potential antibacterial activities.

Structure-diversified terpenoids from Salvia prattii and their protective activity against alcoholic liver diseases.

Eleven previously unreported compounds (1-11), including five diterpenoids (1-5) and six sesquiterpenoids (6-11), together with two known diterpenoids (12-13), have been isolated from the roots of Salvia prattii. Their structures were comprehensively elucidated through spectroscopic methods, and their configurations were established using computational C nuclear magnetic resonance and electronic circular dichroism. Compound 1 was found to be an abietane-type diterpenoid with a novel rearrangement generated from the cleavage of the C-4/5 chemical bond, 20-methyl shift, and the rearrangement of the C-10 side chain.

Two undescribed benzopyran derivatives from L. with their in vitro anti-inflammatory activity in lipopolysaccharide-activated RAW 264.7 cells.

Previous studies on L. have shown the existence of coumarins and their anti-inflammatory effect. Phytochemical work was conducted to investigate the bioactive compounds, leading to the isolation of two undescribed benzopyran derivatives, namely ranunsceleroside A () and B (), together with two known coumarins (, ) from the whole plant of L.

Chemical Constituents of Turcz and Their In Vitro Antioxidant, Anti-Inflammatory and Cytotoxic Activities.

Three novel compounds () along with twenty-six known compounds, two known steroids () and twenty-four known phenylpropanoids () were isolated from the whole plant of Turcz. The structures of the three new compounds were elucidated on the basis of ESI-MS, HR-ESIMS, 1D and 2D NMR, IR, UV spectroscopic data. The absolute stereochemistry of compound was determined by the Gauge-Including Atomic Orbitals (GIAO) method.

Anthraquinones from the Aerial Parts of with Their NO Inhibitory and Antibacterial Activities.

The present study aimed to identify the composition of the aerial parts of L. A chemical investigation on the EtOAc extracts from the aerial parts of resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (-), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data.

Antibacterial Prenylated -Hydroxybenzoic Acid Derivatives from and Identification of Putative Prenyltransferases.

Twelve hitherto unknown tandem prenylated -hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant . Compounds , , and exhibited moderate inhibitory activity against subsp. ATCC29213 with MIC values ranging from 7.

Structure Revision of Four Classes of Prenylated Aromatic Natural Products Based on a Rule for Diagnostic C NMR Chemical Shifts.

Errors in elucidating the structures of four natural classes of prenylated aromatic compounds with 2,3-epoxy, 2,3-dihydroxy, and cyclization with an -phenolic hydroxyl to give a pyran or furan ring moiety are frequent and inevitable. Based on rigorous literature research and a series of chemical transformation experiments, a rule for the rapid determination of these four classes of prenylated derivates based on C NMR data was formulated, and 57 corrections featuring these fragments were accordingly reported.

Total Synthesis of Gastrodinol via Photocatalytic 6π Electrocyclization.

The first total synthesis of gastrodinol, an unprecedented poly--cresol-substituted natural product with a rearranged and reconstructed C ring moiety, is reported. Our synthesis features a convergent fragment approach. The Sonogashira coupling reaction forges the two segments together to furnish the conjugated ene-yne.

Structural characterization and hypoglycemic effect via stimulating glucagon-like peptide-1 secretion of two polysaccharides from Dendrobium officinale.

Two polysaccharides, named DOP-1 and DOP-2, with molecular weights of 6.8 kDa and 14.3 kDa, respectively, were isolated and purified from the stems of Dendrobium officinale.

13,27-Cycloursane, ursane and oleanane triterpenoids from the leaves of Lucuma nervosa.

One hitherto unknown 24-nor-13,27-cycloursane-type triterpenoid, lucumic acid A (1), one new 24-nor-ursane triterpenoid, lucumic acid B (2), along with six known triterpenoids were isolated from the ethanol extract of the leaves of Lucuma nervosa. Their structures were established on the basis of spectroscopic data interpretation. Lucumic acid A (1) is the first example of a 24-nor-triterpenoid with a 13,27-cyclopropane ring.

Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents.

In order to better understand the structure-activity relationship of mangostin, a series of xanthone derivatives based on α-mangostin were designed and synthesized. All the compounds were evaluated for their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using MTT assays. Most of them showed cytotoxicity and most of all, compounds 1a and 2h showed the highest cytotoxic potency by HL-60 cancer cell lines with IC values of 5.

Design, synthesis and cholinesterase inhibitory activity of -mangostin derivatives.

-mangostin, a polyphenol xanthone derivative, was mainly isolated from pericarps of the mangosteen fruit ( L.). In present investigation, a series of derivatives were designed, synthesised and evaluated for their inhibitory activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).