Thermal accelerated urease-driven hyaluronan-targeted melanin nano-missile for bio-radar detection and chemodrug-free phototherapy.

Polymer-based nanomotors are attracting increasing interest in the biomedical field due to their microscopic size and kinematic properties which support overcoming biological barriers, completing cellular uptake and targeted blasting in limited spaces. However, their applications are limited by the complex viscous physiological environment and lack of sufficient biocompatibility. This manuscript firstly reports a natural melanin nano-missile of MNP@HA-EDA@Urease@AIE PS (MHUA) based on photothermally accelerated urease-driven to achieve chemodrug-free phototherapy.

The impact of industrial structure adjustment on the spatial industrial linkage of carbon emission: From the perspective of climate change mitigation.

Industrial structure adjustment is an effective way to reduce carbon emissions. When adjusting the industrial structure, changes in the input and output of industrial sectors in one region may cause changes in industrial sectors of other regions, resulting in inter-regional industrial linkages. What is the impact of industrial structure adjustment on the linkages, and how does it impact climate change? The modified gravity model combines the influence and inductive coefficients to build the carbon emission industrial spatial linkage network (ISL) using social network analysis (SNA) in this work with the data of China's 2008-2019 provincial carbon emissions.

How do resource dependence and technological progress affect carbon emissions reduction effect of industrial structure transformation? Empirical research based on the rebound effect in China.

Under the guidance of carbon peak and carbon neutral targets, the industrial structure transformation is vital for carbon emissions reduction in China. However, there is a rebound effect of carbon emissions during the industrial structure transformation. Resource dependence and technological progress have significant impacts on industrial structure transformation and its carbon reduction effect.

Photothermal interference urease-powered polydopamine nanomotor for enhanced propulsion and synergistic therapy.

Enzyme-powered nanomotors with active motion have opened a new door in design of biocompatible drug delivery systems for cancer treatment. However, the movement of them still faces huge challenges due to the viscous physiological environment. To address this issue, we developed a photothermal interference (PTI) urease-modified polydopamine (PDA) nanomotor (PDA@HSA@Ur) for deeper-penetration of doxorubicin (DOX) through improved motion.

NIR as a "trigger switch" for rapid phase change, on-demand release, and photothermal synergistic antibacterial treatment with chitosan-based temperature-sensitive hydrogel.

Temperature-sensitive hydrogels have shown good performances as wound dressing owing to their ability to fill wounds in the liquid state and to release drugs in a solid state. However, their treatment efficiency is restricted by the phase transition time. In this study, we developed a photothermal synergistic chitosan-based temperature-sensitive hydrogel, h-EGF-CS/β-GP-MPDA@Cip, with the unique properties of rapid phase transition and drug release under near-infrared light (NIR).

A Meta-Analysis of Efficacy and Safety of Infliximab for Prevention of Postoperative Recurrence in Patients with Crohn's Disease.

Objective: We sought to investigate the efficacy and safety of Infliximab for prevention of postoperative recurrence in patients with Crohn's disease (CD), in a meta-analysis of clinical trial results.

Methods: The Medline, Embase, PubMed, and Web of Science databases were systematically searched for suitable studies. A meta-analysis of enrolled studies was performed to analyze the efficacy of Infliximab on outcomes regarding the prevention of postoperative recurrence of CD.