Meta-analysis of the accuracy for RASSF1A methylation in bronchial aspirates for the diagnosis of lung cancer.

Objective: To establish the diagnostic accuracy of RASSF1A (Ras association domain family 1 isoform) methylation using bronchial aspirates as an auxiliary method for diagnosing lung cancer through a systematic review and meta-analysis.

Methods: Studies published prior to October 30, 2022, were retrieved from the Embase, PubMed, Web of Science, and Wan Fang databases using the keywords "lung cancer", "RASSF1A", "methylation", and "bronchial aspirates". A fixed or random effect model was used to calculate the combined sensitivity, specificity, positive likelihood ratios (LR), negative LR, diagnostic odds ratio (DOR), along with the respective 95% confidence intervals (CIs) and the area under the curve (AUC) with Q index.

Fermented Powder, a New Potential Feed Additive for Broilers to Improve the Growth Performance and Health.

A total of 320 1-day-old broilers were randomly divided into five groups. The control group (CON) received a basal diet, while the FAP4, FAP2, and FAP1 groups were provided with the basal diet supplemented with 4%, 2%, and 1% fermented powder, respectively. The unfermented powder (UAP2) group was fed the basal diet supplemented with 2% UAP.

Tip-Enhanced Sub-Femtomolar Steroid Immunosensing via Micropyramidal Flexible Conducting Polymer Electrodes for At-Home Monitoring of Salivary Sex Hormones.

Noninvasive testing and continuous monitoring of ultralow-concentration hormones in biofluids have attracted increasing interest for health management and personalized medicine, in which saliva could fulfill the demand. Steroid sex hormones such as progesterone (P4) and β-estradiol (E2) are crucial for female wellness and reproduction; however, their concentrations in saliva can vary down to sub-pM and constantly fluctuate over several orders of magnitude. This remains a major obstacle toward user-friendly and reliable monitoring at home with low-cost flexible biosensors.

APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer's Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation.

Background: There is limited information about gene-environment interaction on the occurrence and the progression of Alzheimer's disease.

Objective: To explore the effect of environmental low-dose cadmium (Cd) exposure on the progress of Alzheimer's disease and the underlining mechanism.

Methods: We administered 1 mg/L, 10 mg/L cadmium chloride (treated groups), and water (control group) to C57BL/6J and APP/PS1 mice through drinking water, from one week before mating, until the offspring were sacrificed at 6 months of age.

Development of a large-field streak tube for underwater imaging lidar.

Streak tube imaging lidar (STIL) can obtain 4-D images of a target, and its performance is mainly determined by the streak tube sensor. To obtain a large field of view, we developed a streak tube with a photocathode length as large as 35.3 mm, which is larger than the commonly used ST-HDR (30 mm).

High-Transconductance, Highly Elastic, Durable and Recyclable All-Polymer Electrochemical Transistors with 3D Micro-Engineered Interfaces.

Organic electrochemical transistors (OECTs) have emerged as versatile platforms for broad applications spanning from flexible and wearable integrated circuits to biomedical monitoring to neuromorphic computing. A variety of materials and tailored micro/nanostructures have recently been developed to realized stretchable OECTs, however, a solid-state OECT with high elasticity has not been demonstrated to date. Herein, we present a general platform developed for the facile generation of highly elastic all-polymer OECTs with high transconductance (up to 12.

Reversibly Stretchable Organohydrogel-Based Soft Electronics with Robust and Redox-Active Interfaces Enabled by Polyphenol-Incorporated Double Networks.

Hydrogel electrolytes as soft ionic conductors have been extensively exploited to establish skinlike and biocompatible devices. However, in many common hydrogels, there exists irreversible elongation upon prolonged stretching cycles and poor interfacial contact, which have significantly hindered their practical applications where long-term operation at large deformations is needed. Herein, multifunctional soft electronic devices with reversible stretchability and improved electrode/electrolyte interfaces are demonstrated by employing polyacrylamide-based double-network organohydrogel electrolytes soaked with a high content of tannic acid (TA) that affords multiple noncovalent interactions and redox activity.

Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice.

Long-term consumption of arsenic-contaminated rice has become a public health issue that urgently needs to be addressed. In this study, mice were exposed to arsenic in rice (low dose, 0.91 mg/kg; medium dose, 9.

Stretchable, Healable, and Degradable Soft Ionic Microdevices Based on Multifunctional Soaking-Toughened Dual-Dynamic-Network Organohydrogel Electrolytes.

Electronic materials and devices that can mimic biological systems featured with elasticity, toughness, self-healing, degradability, and environmental friendliness drive the technological developments in fields spanning from bioelectronics, biomedical diagnosis and therapy, electronic skin, and soft robotics to Internet-of-Things with "green" electronics. Among them, ionic devices based on gel electrolytes have emerged as attractive candidates for biomimetic systems. Herein, we presented a straightforward approach to demonstrate soft ionic microdevices based on a versatile organohydrogel platform acting as both a free-standing, stretchable, adhesive, healable, and entirely degradable support and a highly conductive, dehydration- and freezing-tolerant electrolyte.

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy.

The precision delivery of anti-cancer agents which aim for targeted and deep-penetrated delivery as well as a controlled release at the tumor site has been challenged. Here, we fabricate iron oxide nanoparticle shelled microbubbles (NSMs) through self-assembly, synergizing magnetic, acoustic, and optical responsiveness in one nanotherapeutic platform. Iron oxide nanoparticles serve as both magnetic and photothermal agents.

Highly sensitive resonant sensor using quartz resonator cluster for inclination measurement.

Quartz crystal resonators are suitable for digital output sensors due to their sensitivity to force. This paper presents a highly sensitive inclinometer sensor with a quartz resonator cluster. The force sensitive resonator cluster is designed on the quartz substrate to eliminate common-mode disturbances, such as temperature, as well as to improve sensitivity to force.

Perfluorooctane sulfonate enhances mRNA expression of PPARγ and ap2 in human mesenchymal stem cells monitored by long-retained intracellular nanosensor.

Perfluorooctane sulfonate (PFOS) has been widely used as a surface coating for household products. It still exists in living environments despite being restricted, due to its bioaccumulation and long half-life. Studies have shown that PFOS has the ability to induce adipogenic differentiation of human cells.

Arsenic concentrations, diversity and co-occurrence patterns of bacterial and fungal communities in the feces of mice under sub-chronic arsenic exposure through food.

Background: Arsenic, a global pollutant and a threshold-free primary carcinogen, can accumulate in rice. Previous studies have focused on arsenic poisoning in drinking water and the effects on gut microbes. The research on arseniasis through food, which involves the bio-transformation of arsenic, and the related changes in gut microbiome is insufficient.

Diversity and Co-Occurrence Patterns of Soil Bacterial and Fungal Communities of Chinese Habitats at Shergyla Mountain, Tibet: Implications for the Occurrence.

Chinese is a well-known medicinal larva-fungus symbiote distributed in the Qinghai-Tibetan Plateau and adjacent areas. Previous studies have involved its artificial cultivation but commercial cultivation is difficult to perform because the crucial factors triggering the occurrence of Chinese are not quite clear. The occurrence of Chinese is greatly affected by the soil environment, including the soil's physicochemical and microecological properties.

Skin-Inspired Surface-Microstructured Tough Hydrogel Electrolytes for Stretchable Supercapacitors.

Double-network tough hydrogels have raised increasing interest in stretchable electronic applications as well as electronic skin (e-skin) owing to their excellent mechanical properties and functionalities. While hydrogels have been extensively explored as solid-state electrolytes, stretchable energy storage devices based on tough hydrogel electrolytes are still limited despite their high stretchability and strength. A key challenge remains in the robust electrode/electrolyte interface under large mechanical strains.

[Synthesis and Study on Adsorption Property of Congo Red Molecularly Imprinted Polymer Nanospheres].

Molecularly imprinted polymer nanospheres (MIP) were prepared with Congo red as the template, methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross linker, azodiisobutyronitrile (AIBN) as an initiator, and acetonitrile as the porogen by precipitation polymerization. The morphology of MIP was characterized by SEM and TEM which showed that the diameter of MIP was nanometer grade (90 nm) and the shape was homogeneous. The specific surface area and pore volumes of MIP and NIP were examined through Brunauer-Emett-Teller method of nitrogen adsorption experiments.

[Synthesis and adsorption property of Cd(II) - 8-hydroxyquinoline molecularly imprinted polymer microspheres].

Cd(II) ion could form a stable complex with 8-hydroxyquinoline (molar rate = 1 : 1) in ethanol solution as revealed by ultraviolet spectrum analysis. Based on this molar rate of Cd(II) ions and 8-hydroxyquinoline, Cd(II) ions imprinting polymer microspheres were synthesized by water-in-oil-in-water (W/O/W) emulsions polymerization, using metal Cd(II) ions as template, 8-hydroxyquinoline as ligand, methacrylic acid as functional monomer, ethylene acrylic acid methyl ester as cross-linker, and azodiisobutyronitrile as initiator in aqueous phase. The influences of the dosage of emulsifier, porogen and outer aqueous phase on the morphology and adsorption property of MIP were studied.

A novel chemiluminescence system with diperiodatonickelate (IV) for the determination of adrenaline.

A novel chemiluminescence (CL) system with diperiodatonickelate (IV) (DPN) was developed for the determination of adrenaline for the first time. The possible CL emission mechanism was briefly discussed by comparing the fluorescence emission spectra with CL spectra. Under the optimum conditions, the relative CL intensity was linear over the concentration of AD ranging from 1.