[Effects of selected phages with specific peptide ligands on the biological behaviors of ovarian cancer cells].

Objective: To evaluate the effects of the selected phages with the specific peptide ligands upon the biological behaviors of the ovarian cancer cells.

Methods: Two ovarian cancer cell lines, A2780 and SKOV3, were used in the study. They were divided into three groups respectively: study group, blank control group and negative control group.

[Expression of survivin in ovarian epithelial carcinoma and its correlation with expression of Fas and FasL].

Background & Objective: Recent research had shown that survivin, a new member of the inhibitors of apoptosis proteins (IAP) family, which also plays an important role in mitosis and cell apoptosis, and selectively overexpressed in common human cancers. This study was designed to examine the expression of survivin and its correlation with expression of Fas and FasL in ovarian epithelial carcinoma.

Methods: Immunohistochemical assay (SP method) was used to detect the expression of survivin, Fas and FasL genes in 84 ovarian cancer tissues, 39 benign tumors of ovary, and 20 normal ovary tissues.

[Selection of targets locating on the surface of epithelial ovarian cancer cells by using phage peptide library].

Objective: The aim of this study was to select specific targets locating on the surface of epithelial ovarian cancer cells.

Methods: Peptide phage display library was used to isolate specific ligand to ovarian cancer cell receptors. The diluted library was incubated with the normal ovarian cells that primarily cultured before hand, and then the supernatant of nonbonding phage was added to the first epithelial ovarian cancer cell line A2780.