J Antimicrob Chemother
September 2024
The polymyxins are important antimicrobial agents against antibiotic-resistant gram-negative bacilli. In 2020, the Clinical and Laboratory Standards Institute modified the clinical breakpoints for polymyxin susceptibility test by eliminating the "susceptible" interpretive category, only reporting intermediate (≤2 mg/L) and resistant (≥4 mg/L). However, the European Committee on Antimicrobial Susceptibility Testing recommended the use of clinical breakpoints of ≤2 mg/L as susceptible and >2 mg/L as resistant.
View Article and Find Full Text PDFZhonghua Liu Xing Bing Xue Za Zhi
September 2013
Acta Pharmacol Sin
March 2008
Aim: To identify the location and the relationship, and to analyze the genetic background of 2 plasmid-mediated quinolone resistance genes, qnrB4 and qnrS1, carried by a clinical strain of Klebsiella pneumoniae (K pneumoniae).
Methods: The plasmids carrying qnrB4 or qnrS1 were identified by Southern blotting. A HindIII fragment containing qnrB4 or qnrS1 was cloned into plasmid puc18 and sequenced.
Zhonghua Yi Xue Za Zhi
January 2006
Objective: To investigate the trend of resistance to antimicrobial agents among clinical isolates of Escherichia coli 1990-2004.
Methods: Agar diffusion test was used to analyze the changes of drug susceptibility of 33,495 strains of E. coli isolated from 11 hospitals in Shanghai to 21 antimicrobial agents 1990-2004.
Diagn Microbiol Infect Dis
December 2004
To evaluate the in vitro activity of tigecycline, the minimum inhibitory concentrations (MICs) of tigecycline against 1,201 strains of recent clinical isolates from 10 hospitals in Shanghai, China were determined and compared with selected comparators. Results showed that tigecycline had broad-spectrum antimicrobial activity. It was highly active against Gram-positive cocci, including methicillin-resistant Staphylococcus spp.
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