Publications by authors named "Fu-pin Hu"
Establishment of epidemiological cut-off values for eravacycline, against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii and Staphylococcus aureus.
J Antimicrob Chemother
September 2024
Article Synopsis
- The study aimed to determine the epidemiology cut-off (ECOFF) values for eravacycline against various bacterial species, including E. coli and S. aureus, through a multi-centre research effort in China.
- Researchers analyzed 2500 bacterial samples from hospitals in China and measured the minimum inhibitory concentrations (MICs) of eravacycline, adhering to EUCAST guidelines.
- The findings showed specific ECOFF values for each species, indicating effective thresholds for classification, and suggest that eravacycline could be a viable treatment option for complicated intra-abdominal infections caused by these pathogens.
The polymyxins are important antimicrobial agents against antibiotic-resistant gram-negative bacilli. In 2020, the Clinical and Laboratory Standards Institute modified the clinical breakpoints for polymyxin susceptibility test by eliminating the "susceptible" interpretive category, only reporting intermediate (≤2 mg/L) and resistant (≥4 mg/L). However, the European Committee on Antimicrobial Susceptibility Testing recommended the use of clinical breakpoints of ≤2 mg/L as susceptible and >2 mg/L as resistant.
View Article and Find Full Text PDF[Analysis on nosocomial infection of Corynebacterium].
Zhonghua Liu Xing Bing Xue Za Zhi
September 2013
Article Synopsis
- * All mupirocin-resistant strains carried the mupA gene on large plasmids, indicating a genetic basis for their resistance.
- * Significant differences in antibiotic resistance patterns were observed between isolates from the two cities, and molecular typing showed distinct profiles, suggesting the prevalence of resistance clones in clinical settings.
Coexistence of qnrB4 and qnrS1 in a clinical strain of Klebsiella pneumoniae.
Acta Pharmacol Sin
March 2008
Aim: To identify the location and the relationship, and to analyze the genetic background of 2 plasmid-mediated quinolone resistance genes, qnrB4 and qnrS1, carried by a clinical strain of Klebsiella pneumoniae (K pneumoniae).
Methods: The plasmids carrying qnrB4 or qnrS1 were identified by Southern blotting. A HindIII fragment containing qnrB4 or qnrS1 was cloned into plasmid puc18 and sequenced.
[Changes of antimicrobial resistance among clinical isolates of Escherichia coil in Shanghai 1990-2004].
Zhonghua Yi Xue Za Zhi
January 2006
Objective: To investigate the trend of resistance to antimicrobial agents among clinical isolates of Escherichia coli 1990-2004.
Methods: Agar diffusion test was used to analyze the changes of drug susceptibility of 33,495 strains of E. coli isolated from 11 hospitals in Shanghai to 21 antimicrobial agents 1990-2004.
In vitro activities of tigecycline against clinical isolates from Shanghai, China.
Diagn Microbiol Infect Dis
December 2004
To evaluate the in vitro activity of tigecycline, the minimum inhibitory concentrations (MICs) of tigecycline against 1,201 strains of recent clinical isolates from 10 hospitals in Shanghai, China were determined and compared with selected comparators. Results showed that tigecycline had broad-spectrum antimicrobial activity. It was highly active against Gram-positive cocci, including methicillin-resistant Staphylococcus spp.
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