[Morphological changes of non-apoptotic programmed cell death of polymorphonuclar neutrophils induced by ONO-AE-248].

Aim: To investigate the morphological changes of polymorphonuclar neutrophils (PMNs) induced by ONO-AE-248, a selective agonist of EP3.

Methods: The morphological changes of PMNs treated with or without ONO-AE-248 were observed by electron microscope, fluorescence microscope and confocal microscope.

Results: A unique form of PMNs death was rapidly caused by ONO-AE-248.