Publications by authors named "Fu-lan Yang"
Whether the expression status of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) receptor and Ki-67 show concordance between the primary tumors and the synchronous axillary lymph node (ALN) metastases has been discussed in numerous studies. However, to date, the results of these studies remain controversial. Therefore, the present study aimed to investigate whether the expression of ER, PR, HER-2 and Ki-67 was in concordance between the primary tumors and synchronous ALN metastases in patients with operable breast cancer (BC).
View Article and Find Full Text PDFIntroduction: The aim of this study was to evaluate the expression of C-type lectin domain family 3 member A (CLEC3A) and its clinical significance in breast invasive ductal cancer (IDC) as well as its effect on breast cancer (BC) cell proliferation and metastasis. In this study, the level of CLEC3A expression in The Cancer Genome Atlas (TCGA) datasets was analyzed.
Materials And Methods: Clinical collected samples and BC cells were measured using quantitative reverse transcription polymerase chain reaction.
Using the phage display biopanning technique, we have previously identified a heptapeptide KLWVIPQ which specifically binds to the surface of the IFN-α-sensitive but not the IFN-α-resistant CML cells. The effects of this heptapeptide on the IFN-α-sensitive CML cells were investigated in the present study. IFN-α-sensitive KT-1/A3 and IFN-α-resistant KT-1/A3R CML cells were transfected by pEGFP-KLWVIPQ expression vector and/or induced by IFN-α.
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- Hepatocellular carcinoma (HCC) is a common cancer, and while Interferon-α (IFN-α) is used to treat it, patients eventually become resistant.
- The study found that IFN-α boosts the expression of ISG15, a protein with potential cancer-fighting properties, but does not trigger cell death in HCC cells.
- Instead, when ISG15 is overexpressed, it leads to increased cell death and involves key proteins like p53 and p21, suggesting that enhancing ISG15 could be a promising strategy for tackling IFN-α-resistant HCC.
Article Synopsis
- Lung adenocarcinoma (ADC) is a key type of lung cancer, and the study investigates the link between genetic variations in DNA repair genes XPD-751, XRCC1-399, and OGG1-326 and lung ADC in Han Chinese individuals.
- The research involved analyzing blood samples from 82 lung ADC patients and 201 healthy controls from Hunan Province, China, using a specific DNA analysis technique.
- While no significant differences were found in individual polymorphism frequencies, a multifactor analysis indicated that combined variations at the three gene sites are associated with an increased lung ADC risk.
Article Synopsis
- Lung cancer is a major cause of cancer-related deaths, and this study examined the link between lung cancer risk and genetic variations in specific metabolic enzymes (CYP1A1, CYP2D6, and CYP2A6).
- Genomic DNA was collected from 201 healthy individuals and 168 lung cancer patients, and no significant differences in gene polymorphisms were found between the two groups for the individual enzymes.
- However, a significant three-way interaction among the polymorphisms of these enzymes was identified, suggesting that their combined effects may increase genetic susceptibility to lung cancer in certain populations, like the Han ethnic group in Central South China.