Association between admission blood pressure and spontaneous reperfusion and long-term prognosis in STEMI patients: an observational and multicenter study.

Background: This study aims to assess the associations of admission systolic blood pressure (SBP) level with spontaneous reperfusion (SR) and long-term prognosis in ST-elevation myocardial infarction (STEMI) patients.

Methods: Data from 3809 STEMI patients who underwent primary percutaneous coronary intervention within 24 h, as recorded in the Chinese STEMI PPCI Registry (NCT04996901), were analyzed. The primary endpoint was SR, defined as thrombolysis in myocardial infarction grade 2-3 flow of IRA according to emergency angiography.

Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.

Importance: There is no current consensus on the role of chemotherapy in addition to radiation for postoperative adjuvant treatment of patients with early-stage cervical cancer with adverse pathological factors.

Objective: To evaluate the clinical benefits of sequential chemoradiation (SCRT) and concurrent chemoradiation (CCRT) compared with radiation alone (RT) as a postoperative adjuvant treatment in early-stage cervical cancer.

Design, Setting, And Participants: After radical hysterectomy at 1 of 8 participating hospitals in China, patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB to IIA cervical cancer with adverse pathological factors were randomized 1:1:1 to receive adjuvant RT, CCRT, or SCRT.

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.

Nuclear receptor Nur77 participates in multiple metabolic regulations and plays paradoxical roles in tumorigeneses. Herein, we demonstrated that the knockout of Nur77 stimulated mammary tumor development in two mouse models, which would be reversed by a specific reexpression of Nur77 in mammary tissues. Mechanistically, Nur77 interacted and recruited corepressors, the SWI/SNF complex, to the promoters of and to suppress their transcriptions, which hampered the fatty acid uptake, leading to the inhibition of cell proliferation.

Evaluation of related factors, prediction and treatment drugs of no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction after direct PCI.

This study determined the related factors of no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction (STEMI) after direct percutaneous coronary intervention (PCI), and evaluated related factor scores in predicting the occurrence of no-reflow phenomenon and drug treatments. A total of 203 patients with acute STEMI receiving PCI who were admitted to the Department of Cardiovascularology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine (Xiangyang, China) from January 2015 to December 2016 were selected.

Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy.

The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups.

[Research on predicting the qualities of stem of alfalfa hay by near infrared reflectance spectroscopy].

The present research was attempted to predict the qualities of stem of alfalfa (Medicago sativa L. ) without separation from the whole plant by near infrared reflectance spectroscopy and discussed the feasibility of using the near infrared reflectance spectra information of the whole object to predict the qualities of a certain part. Sixty six whole alfalfa hay samples of separated stems from leaves were collected and they were distinguishing by years, cultivars, cuts and growing periods.

[Clinical characteristics and prognosis of epithelial ovarian cancer in young women].

Background & Objective: Epithelial ovarian cancer mostly appears in aged women, but rarely in young women. Little is known about the clinical characteristics and prognosis of epithelial ovarian cancer in women aged below 35 years. This study was to evaluate the clinical characteristics, treatment, survival and prognosis of young patients with epithelial ovarian cancer.

[Determination of main fiber compositions of alfalfa hay by near infrared reflectance spectroscopy].

Sixty alfalfa samples, with different growth stage, cultivars, and preparing method (drying by oven, shade and sun), were selected to study the potential of determination of cellulose, hemicellulose and lignin content in the present research. The result showed that the correlation coefficient of cross-validation (R(cv)), determination coefficient of external validation(r2) and the ratio of standard deviation to root mean square error of prediction (RPD) of cellulose and lignin were 0.97, 0.

[Quality prediction of alfalfa hay using Fourier transform near infrared reflectance spectroscopy].

Alfalfa hay has high nutritive value, and it is one of the most important protein feed for domestic animals. The quality parameters of alfalfa hay, including CP, Ash, NDF, ADF, ADL and IVDMD, were predicted using Fourier transform near infrared reflectance spectroscopy with PLS regression in this test. Then the 6 models were validated by cross-validation and external-validation.

[Comparison of therapeutic efficacy between TP regimen and CBP regimen on epithelial ovarian cancer after optimal cytoreductive operation].

Background & Objective: The most effective treatment for epithelial ovarian cancer is the combination of surgical operation and chemotherapy. Complete removal of the tumor is the key of surgical treatment; TP regimen (paclitaxel plus carboplatin) is the preference for postoperative chemotherapy, but its superiority is controversial. This study was to compare the efficacy of TP regimen and CBP regimen (cyclophosphamide, bleomycin plus carboplatin/cisplatin) on epithelial ovarian cancer.

[Expression and clinical significance of uPA and PAI-1 in epithelial ovarian cancer].

Background & Objective: Recent researches showed that urokinase-type plasminogen activator (uPA) and its inhibitor, plasminogen activator inhibitor (PAI)-1, play an important role in the invasion and metastasis of solid tumors. However, their correlations to epithelial ovarian cancer have seldom been reported. This study was to investigate the roles of uPA and PAI-1 in the invasion and metastasis of epithelial ovarian cancer, to clarify their localization and relationship with prognosis.

[Evaluation of transvaginal ultrasonography-color Doppler energy imaging in surveillance of gynecologic malignant tumors after operation].

Background & Objective: Transvaginal ultrasonography (TVS) and color Doppler energy imaging (CDE) have been already applied in ultrasonography diagnosis extensively, but articles about the methods in surveillance of gynecologic malignant tumors after operation are few. The objective of this study was to evaluate TVS-CDE in surveillance of gynecologic malignant tumors after operation.

Methods: Fifty-four cases of gynecologic malignant tumors after operation, which were doubted as recurrent malignant tumors in clinic, were scanned with transabdominal ultrasonography (TAS), TVS, and TVS-CDE.

[How to increase the optimal rate of secondary cytoreductive surgery in recurrent epithelial ovarian cancer].

Background & Objective: Optimal secondary cytoreduction is of prognostic importance for recurrent epithelial ovarian cancer. To increase the optimal rate of secondary cytoreductive surgery in these patients is helpful for improving the prognosis of recurrent epithelial ovarian cancer patients. In this retrospective study, we investigated how to increase the optimal rate of secondary cytoreductive surgery in recurrent epithelial ovarian cancer patients.

[Analysis of clinical efficiency of treatment for 179 geriatric women with stage I or II cervical carcinoma].

Background & Objective: Elderly women with cervical carcinoma have the features of poor prognosis and high incidence rate of complications. This study was designed to evaluate the prognostic impact of surgery versus radiotherapy in old women with stage I and stage II cervical carcinoma and seek suitable treatment for such patients.

Methods: Clinical data of 179 elderly women with stage Ia to stage IIb cervical cancer were analyzed retrospectively.

[Clinical analysis of 57 patients with ovarian dysgerminoma].

Background & Objective: Ovarian dysgerminoma is an uncommen ovarian malignancy. Its clinical features are special and there are many factors influencing the prognosis. If treated properly, the patient can be cured.

[Phase II clinical study of topotecan hydrochloride in patients with recurrent advanced ovarian cancer].

Background And Objective: Clinical studies showed there was no satisfying treatment of the patients with recurrent advanced ovarian cancer by using chemotherapy of combining platinum, and it is very important for oncologist to seek the second-line drugs to treat the patients with recurrent ovarian cancer. The current study was designed to evaluate the efficacy and toxicity of single agent Topotecan hydrochloride in the patients with recurrent advanced ovarian cancer.

Material And Method: A total of 31 patients with recurrent ovarian cancer in a multiple centers clinical trial were treated with Topotecan 1.

[Expression and clinical significance of p53 and c-erbB2 in geriatric women with cervical carcinoma].

Background & Objective: Few reports have reported on molecular biological study of cervivcal carcinoma in eldely woman, So the authors designed this study to evaluate the expression and clinical significance of tumor suppressor gene p53 and oncogene c-erbB2 in the progression of this kind of cancer.

Methods: Seventy-nine patients with cervical cancer and 23 with cases of normal cervical epithelium in geriatric people were investigated immunohistochemically for expression of p53 and c-erbB2 in paraffin sections.

Results: The expression of p53 in ICC (invasive cervical carcinoma) and normal epithelium were 18.

[Relationship between expressions of p53, c-erbB2 genes, proliferating cell nuclear antigen and prognosis of patients with ovarian epithelial carcinoma].

Background & Objective: There were a few reports about the relationship between the expressions of p53, c-erbB2 Genes, and proliferating cell nuclear antigen (PCNA) with the prognosis from the patients with ovarian epithelial carcinoma(EOC). But conclusions were difference because of various methods and samples. This study was designed to investigate the relationship between the expressions of p53, c-erbB2 Genes, and PCNA with the prognosis from the patients with EOC.