The study explores how Agaricus blazei extract FA-2-b-β can help overcome drug resistance in T cell acute lymphoblastic leukemia (T-ALL) cell lines.
Various laboratory methods showed that FA-2-b-β effectively inhibited cell growth, induced cell death, and altered the cell cycle in leukemia cells.
The findings suggest that FA-2-b-β works by decreasing key proteins associated with drug resistance and might act through the Wnt signaling pathway, indicating its potential therapeutic role in T-ALL treatment.