Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies.

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs.

Recent advances in iridium(iii) complex-assisted nanomaterials for biological applications.

Phosphorescent iridium(iii) complexes have gained increasing attention in biological applications owing to their excellent photophysical properties and efficient transportation into live cells. Their advantageous properties make them useful tools for enabling the intracellular detection of many different species for biological and medical applications. In this review, we summarize recent studies on the combination of iridium(iii) complexes and nanomaterials for intracellular sensing, drug delivery and photodynamic therapy.

Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform.

A sensitive turn-on luminescent sensor for HO based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of HO, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. However, HO can oxidize AgNPs to soluble Ag cations, which restores the luminescence of Ir-1.

Spectroscopic studies and structures of trans-ruthenium(II) and ruthenium(III) bis(cyanide) complexes supported by a tetradentate macrocyclic tertiary amine ligand.

trans-[Ru(16-TMC)(C[triple bond]N)2] (1; 16-TMC = 1,5,9,13-tetramethyl-1,5,9,13-tetraazacyclohexadecane) was prepared by the reaction of trans-[Ru(16-TMC)Cl2]Cl with KCN in the presence of zinc powder. The oxidation of 1 with bromine gave trans-[Ru(16-TMC)(CN)2]+ isolated as PF6 salt (2.PF6).