Human neutrophil peptide 1 promotes immune sterilization in vivo by reducing the virulence of multidrug-resistant Klebsiella pneumoniae and increasing the ability of macrophages.

By studying the expression in patients and cell modeling in vitro, antimicrobial peptides for Klebsiella were screened. Killing curve and membrane permeability experiments are used to study the antibacterial effect of antimicrobial peptides in vitro. Cytotoxicity-related indicators including lipopolysaccharide (LPS), capsule polysaccharide (CPS), and outer membrane protein expression were measured.

Application of Non-invasive Positive Pressure Ventilation Combined with PetCO₂ Monitoring for Patients with Chronic Obstructive Pulmonary Disease Combined with Severe Respiratory Failure.

Objective: To investigate the role of PetCO₂ monitoring in non-invasive positive pressure ventilation (NPPV) treatment for chronic obstructive pulmonary disease (COPD) patients combined with severe respiratory failure.

Study Design: A clinical retrospective study.

Place And Duration Of Study: The ICU Emergency Department, Wuxi Second People's Hospital, Wuxi, China, from February 2015 to February 2016.

Resveratrol protects the loss of connexin 43 induced by ethanol exposure in neonatal mouse cardiomyocytes.

Excessive alcohol consumption provides risk to cardiomyopathy with unknown mechanisms. Resveratrol, a plant polyphenol, is widely reported for its cardiovascular benefits, while its effect on alcohol-induced impairments in cardiomyocytes largely remains unknown. Effects of resveratrol on the cardiomyocytes under ethanol insult were studied in vitro.

[The changes in insulin sensitivity under stress and its clinical significance in the critically ill patients].

Objective: To observe the changes in blood glucose, serum insulin level and insulin resistance of critically ill patients during the acute stage and explore the relationship between the changes and their prognosis.

Methods: Fifty-four patients in intensive care unit (ICU) were enrolled. All the patients were assessed with acute physiology and chronic health evaluation II (APACHE II) scores in 24 hours after admission.