Effective Management of Polycythemia Vera With Ropeginterferon Alfa-2b Treatment.

Background: Polycythemia vera (PV) is a myeloproliferative neoplasm. Ropeginterferon alfa-2b is a new-generation polyethylene glycol-conjugated proline-interferon. It is approved for the treatment of PV at a starting dose of 100 µg (50 µg for patients receiving hydroxyurea (HU)) and dose titrations up to 500 µg by 50 µg increments.

[Clinical Analysis of Hospitalized Children with Primary Immune Thrombocytopenia].

Objective: To investigate the factors affecting the chronicity of childhood primary immune thrombo-cytopenia (ITP) and compare the efficiency of different first-line treatment regimens.

Methods: Children with ITP hospitalized in our hospital from September 2013 to October 2018 were retrospectively analyzed.

Results: Three hundred and one children (150 males and 151 females) were included in this study, with a median age of 8 (0.

[Symptomatic Profiles of 173 Chinese Patients with Essential Thrombocythemia].

Objective: To explore the symptomatic burden of patients with essential thrombocythemia (ET) and its relation with clinical characteristics including the mutation status, therapeutic protocols and sex.

Methods: Total of 173 Chinese ET patients were selected and grouped on the basis of disease characteristics (mutation status, therapeutic pro to- cols, and sex).

Results: All the groups showed low-to-high symptom burden, with the highest in the Hu (hydroxyurea)-group (total symptom score [TSS], 14.

[Clinical Characteristic of "triple-negative" Essential Thrombocythaemia Patients and Mutation Analysis by Targeted Sequencing].

Background: Essential thrombocythemia is a subgroup of myeloproliferative neoplasms. Previous studies identified mutations of JAK2, CALR, and MPL that are closely related with the pathogenesis of myeloproliferative neoplasms. All these mutations contribute to the hyperactivation of JAK2/STAT pathway.

[Clinical Characteristics and Long-Term Outcome of 125 Chinese Young Patients with Essential Thrombocythemia].

Objective: To investigate the clinical characteristics and long-term outcome of Chinese young patients (≤40 years) with essential thrombocythemia(ET), and to develop a thrombosis predicting model specific for young patients with ET, so as to provide a new evidence for risk stratification and treatment.

Methods: Medical records of 125 Chinese young patients with newly diagnosed of ET were retrospectively analyzed.

Results: The median age at diagnosis was 32 (18-40) years old, with 37 males and 88 females.

Formation and Applications of the Secondary Fiber Bragg Grating.

Being one of the most proven fiber optic devices, the fiber Bragg grating has developed continually to extend its applications, particularly in extreme environments. Accompanying the growth of Type-IIa Bragg gratings in some active fibers, a new resonance appears at the shorter wavelength. This new type of grating was named "secondary Bragg grating" (SBG).

Spectral tuning of the diameter-dependent-chirped Bragg gratings written in microfibers.

Chirped fiber Bragg gratings can straightforwardly and efficiently be fabricated onto microfibers with a uniform phase mask. Due to the variation of the propagating constant, which depends on the fiber diameter, the broadband spectrum of the grating can be formed. Depending on the different responses to the ambient refractive index in different parts of the grating, the bandwidth of the grating can be tuned by changing the surrounding solution.

1-μm-wavelength ytterbium-doped fiber laser based on the third harmonic reflection in secondary-type-In Bragg gratings.

In this Letter, a 1-μm-wavelength fiber laser is proposed through the use of the ytterbium-doped active fiber and the third harmonic Bragg reflectors. Benefiting from the ratio below 0.5 between the core diameter of the fiber and the Talbot length of the UV fringes, enabling the formation of the secondary-type-In grating, the reflector with reflectivity higher than 95% at two-thirds of the designing Bragg wavelength can be fabricated within 2 min.

Thermally triggered fiber lasers based on secondary-type-In Bragg gratings.

The secondary-type-In grating formed in a small-core photosensitivity active fiber is discovered and investigated. Due to the different grating types, the transmission dip of a secondary grating structure chases and integrates with the type-In grating structure as the temperature increases, which strengthens the reflectivity of the grating. By use of these secondary-type-In gratings as Bragg reflectors, a thermally activated distributed Bragg reflector (DBR) fiber laser is proposed, which can be potentially used in high-temperature alarms and sensors.

Type IIa Bragg grating based ultra-short DBR fiber laser with high temperature resistance.

We report on the fabrication of a thermally resistant ultra-short distributed Bragg reflector (DBR) fiber laser based on the photo inscription of two wavelength-matched type IIa gratings in a thin-core Er-doped fiber. With continuous UV exposure, each Bragg reflector initially grows as a type I grating, followed by decay in strength, and then re-grows as a type IIa grating with enhanced thermal resistance. The DBR laser, with an entire length of 13 mm, can stably operate at 600°C with single longitude mode, which provides potential applications in high temperature environments.

[Role of Toll-like receptor 2 in primary immune thrombocytopenia].

The aim of this study was to explore the role of Toll-like receptor (TLR) 2 in primary immune thrombocytopenia (ITP) by detecting TLR2 expression in the peripheral blood lymphocytes of patients with ITP and evaluating the role of TLR2 activation on inflammatory cytokine secretion. A total of 39 ITP patients and 21 normal controls were enrolled in this study. The expression of TLR2 was detected by real-time PCR and flow cytometry, and the concentration of IL-6 and TNF-α in culture supernatant of PBMNC treated with pam3CSK4 for 48 hours were detected by ELISA.

[Clinical characteristics of 520 children with hemophilia in a single medical center].

Objective: To analyze the clinical characteristics, diagnosis and treatment of pediatric hemophilia in single center over the decade.

Methods: A retrospective study was conducted with 520 hemophilic children hospitalized in our medical center between January 2002 and December 2012.

Results: All the patients were male including 438 hemophilia A (HA) and 82 hemophilia B (HB).

[Clinical study on treatment of acute paraquat poisoning].

Objective: To investigate the clinical therapeutic effect of methylprednisolone combined with cyclophosphamide and Etanercept method on acute paraquat poisoning.

Methods: 136 patients with acute paraquat poisoning were divided into the normal therapy group and the intensive therapy group randomly. Methylprednisolone, cyclophosphamide and Etanercept were used in the intensive therapy group.