Publications by authors named "Fu-Long Nan"
Norovirus (NoV) is a zoonotic virus that causes diarrhea in humans and animals. Outbreaks in nosocomial settings occur annually worldwide, endangering public health and causing serious social and economic burdens. The latter quarter of 2016 witnessed the emergence of the GII.
View Article and Find Full Text PDFThe V protein of Newcastle disease virus (NDV) has been shown to inhibit the secretion of interferon (IFN) during infection, which is responsible for the promotion of NDV pathogenicity. However, the ability of the V protein to suppress host innate immunity is not well understood. In this study, we explored the function of V protein and its relationship with virulence by generating V protein-inserted recombinant (r) NDVs.
View Article and Find Full Text PDFNewcastle disease virus (NDV) infects poultry and antagonizes host immunity several mechanisms. Dendritic cells (DCs) are characterized as specialized antigen presenting cells, bridging innate and adaptive immunity and regulating host resistance to viral invasion. However, there is little specific knowledge of the role of DCs in NDV infection.
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- The PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) significantly impacts the global pig industry, with the NADC30-like strain causing recent outbreaks in China.
- The study focuses on the genome of the PRRSV-HB-16-China-2019 strain, which shows high similarity to NADC30 PRRSV but has notable deletions and mutations in its coding regions, particularly in NSP2.
- These genetic changes suggest that PRRSV-HB-16-China-2019 is a new variant that complicates prevention strategies for PRRSV in China, highlighting the ongoing evolution of the virus.
Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that causes reproductive failure in sows and respiratory problems in piglets. PRRSV infection leads to substantial pig mortality and causing huge economic losses so that disease outbreaks caused by the new PRRSV strain from other regions have caused great concern in China. In this study, we analysed the pathogenicity of the novel ORF5 RFLP 1-7-4-like PRRSV strain, named PRRSV-ZDXYL-China-2018-1 in pigs.
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- The porcine circovirus type 3 (PCV3) has been identified as a significant pathogen affecting pigs since its discovery in 2016, leading to major economic losses in the swine industry.
- A study examined 269 mosquito samples from pig farms in China, revealing that 32.0% tested positive for PCV3, suggesting that mosquitoes could play a role in transmitting the virus.
- Genome sequencing of PCV3 from mosquitoes and pigs showed a 100% similarity, with the virus categorized into two clades (PCV3a and PCV3b), further supporting the idea that mosquitoes may contribute to the virus's transmission cycle.
Background: First identified in the United States in 2016, porcine circovirus type 3 (PCV3) is a newly emerging porcine circovirus exhibiting a wide range of clinical syndromes, which may be associated with the pathogenicity observed in pigs.
Results: The aim of this study was to identify and characterize the full genome sequence of PCV3 strains circulating in Northeast China. Herein, 105 lung samples isolated from sick pigs in Northeast China during 2018 were analyzed for PCV3.