Running exercise protects against myelin breakdown in the absence of neurogenesis in the hippocampus of AD mice.

Neurogenesis might influence oligodendrogenesis and selectively instruct myelination in the mammalian brain. Running exercise could induce neurogenesis and protect the myelin sheaths in the dentate gyrus of AD mice. It is unclear whether running exercise can protect myelin sheaths in the absence of neurogenesis in the hippocampus of AD mice.

Exercise Prevents Cognitive Function Decline and Demyelination in the White Matter of APP/PS1 Transgenic AD Mice.

Background: Whether exercise could delay the cognitive function decline and structural changes in Alzheimer's disease (AD) are not fully understood.

Methods: 6-month-old male APP/PS1 double transgenic mice ran four months and then the effects of exercise on the cognitive function and the white matter of AD were investigated.

Results: The mean escape latency of the excercised group was significantly shortened when compared to that of the sedentary group.