Publications by authors named "Fu-Kun Zhang"
Article Synopsis
- Human cytomegalovirus (HCMV) has a complex genome and relies on various cellular factors for replication, particularly emphasizing the role of the host protein WDR11 in the formation of a specialized compartment for virion assembly.
- WDR11 is upregulated during HCMV infection and is crucial for the reorganization of cellular membranes, specifically aiding in the creation of the virion assembly compartment (vAC) necessary for the maturation of virions.
- Disruption of WDR11 function impairs HCMV replication by affecting the Golgi apparatus' remodeling, vAC formation, and ultimately the production of infectious virions, highlighting its essential role in viral life cycle stages.
Background: Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising candidate to be developed as anterograde viral tracers. In our earlier studies, we developed H129-derived anterograde polysynaptic tracers and TK deficient (H129-dTK) monosynaptic tracers.
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- Human cytomegalovirus (HCMV) can establish a persistent infection, which poses risks of severe illness, especially in newborns and people with weakened immune systems.
- In a study involving T98G cells, researchers identified 168 proteins that changed during HCMV latency and reactivation, highlighting the molecular mechanisms involved.
- The study also found that proteins like ApoE and the PI3K pathway significantly influence HCMV infection status, with ApoE promoting latency and blocking the PI3K pathway triggering reactivation.
The roles of the Hippo‑Yes‑associated protein (YAP) pathway in lung injury and repair remain elusive. The present study examined the effects of systemic inhibition or stimulation of YAP activity on lung injury, repair and inflammation in a mouse model of lipopolysaccharide (LPS)‑induced lung injury. Mice were treated with or without YAP inhibitor, verteporfin, or with or without YAP stimulator, XMU‑MP‑1, and intraperitoneally injected with LPS (7.
View Article and Find Full Text PDFVaricella-zoster virus (VZV), a member of the Alphaherpesvirinae subfamily, causes severe diseases in humans of all ages. The viral capsids play critical roles in herpesvirus infection, making them potential antiviral targets. Here, we present the 3.
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