Publications by authors named "Fu-Kai Feng"
Article Synopsis
- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious complications of COVID-19, and clofazimine (CFZ) has potential due to its anti-inflammatory effects.
- A study employed quantitative proteomics to analyze the effects of CFZ on macrophages exposed to LPS-induced inflammation, identifying significant proteins and pathways related to inflammation, such as TLR4/NF-κB/HIF-1α.
- The findings indicated that CFZ reduced inflammatory markers, improved lung health, and increased survival rates, suggesting its potential use as a therapeutic strategy for treating COVID-19 related inflammation.
Purpose: The objective of our study was to investigate the epidemiologic characteristics and prognostic factors in patients with pulmonary acinar cell carcinoma (PACC).
Methods: PACC patients diagnosed between 1975 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The trend in PACC incidence was assessed using joinpoint regression software.
Objective: To understand the characteristics of DNA methyltransferase 3a (DNMT3a) in thymoma associated Myasthenia Gravis reveal its transcriptional regulator network as while as analyze the effect of DNMT3a on Rel/ nuclear factor-kappaB family (RelA/RelB) and its downstream autoimmune regulatory factor (Aire).
Methods: Tissues of 30 patients with thymoma, with or without myasthenia gravis (MG), were collected and the DNMT3a protein expression were evaluated through immunohistochemistry. We performed mRNA expression profiling microarray detection and analysis, and integrated the analysis by constructing protein-protein interaction networks and the integration with other database.