A New Strategy to Fight Metallodrug Resistance: Mitochondria-Relevant Treatment through Mitophagy to Inhibit Metabolic Adaptations of Cancer Cells.

Metabolic adaptations can help cancer cells to escape from chemotherapeutics, mainly involving autophagy and ATP production. Herein, we report a new rhein-based cyclometalated Ir complex, Ir-Rhein, that can accurately target mitochondria and effectively inhibit metabolic adaptations. The complex Ir-Rhein induces severe mitochondrial damage and initiates mitophagy to reduce the number of mitochondria and subsequently inhibit both mitochondrial and glycolytic bioenergetics, which eventually leads to ATP starvation death.

[Study on the risk factors related to severe acute respiratory syndrome among close contactors in Beijing].

Objective: To understand the risk factors on severe acute respiratory syndrome (SARS) among their contacts and to develop effective strategy for its control.

Methods: Available epidemiological data of SARS cases and close contacts were reviewed and analyzed by SPSS.

Results: Out of the 2195 close contacts, 138 (6.