Publications by authors named "Fu-Jian Wan"
Gastric cancer presents a formidable challenge, marked by its debilitating nature and often dire prognosis. Emerging evidence underscores the pivotal role of tumor stem cells in exacerbating treatment resistance and fueling disease recurrence in gastric cancer. Thus, the identification of genes contributing to tumor stemness assumes paramount importance.
View Article and Find Full Text PDFGlucosamine‑phosphate N‑acetyltransferase 1 (GNPNAT1) is a member of the acetyltransferase superfamily, related to general control non‑depressible 5 (GCN5). It has been documented that GNPNAT1 expression is increased in lung cancer, whereas its involvement in breast cancer (BC) remains to be further investigated. The present study aimed to evaluate the expression levels of GNPNAT1 in BC and its effect on BC stem cells (BCSCs).
View Article and Find Full Text PDFArticle Synopsis
- CDCA5 is highly expressed in breast cancer (BC) and its high levels are linked to poorer survival rates in patients.
- Knockdown of CDCA5 in BC cell lines reduced cell proliferation, migration, and the ability to form colonies, indicating its role in cancer progression.
- The study suggests that CDCA5 could serve as a useful biomarker for prognosis and a potential target for breast cancer therapy.