Publications by authors named "Fu-Hong Cai"
Article Synopsis
- Single-cell sequencing technology has advanced the understanding of immune cell subpopulations and their functions, which is vital for studying immune responses in health and disease.
- The newly developed scImmOmics is a curated multi-omics immune database that houses over 2.9 million labeled immune cells from various sequencing technologies, covering 131 immune cell types across 47 tissues and 4 species.
- It provides standardized nomenclature and detailed immune regulatory information, making it a crucial resource for exploring the diversity of immune cells and understanding their regulatory mechanisms at the single-cell level.
scBlood: A comprehensive single-cell accessible chromatin database of blood cells.
Comput Struct Biotechnol J
December 2024
Article Synopsis
- The scATAC-seq technology allows researchers to analyze chromatin accessibility in blood cells at the single-cell level, enhancing our understanding of their genomic characteristics.
- scBlood is a new database that compiles over 770,000 blood cells along with corresponding non-blood cells, featuring data from around 400 high-quality samples across various tissues and diseases.
- The platform enables users to perform detailed analyses, such as cell clustering and functional enrichment, and is designed to be user-friendly for exploring and downloading scATAC-seq data related to blood cells and disorders.
Chromatin accessibility profiles at single cell resolution can reveal cell type-specific regulatory programs, help dissect highly specialized cell functions and trace cell origin and evolution. Accurate cell type assignment is critical for effectively gaining biological and pathological insights, but is difficult in scATAC-seq. Hence, by extensively reviewing the literature, we designed scATAC-Ref (https://bio.
View Article and Find Full Text PDFLightening organelles: A femtosecond laser can excite multiphoton-induced luminescence of graphene oxide nanoparticles. The flow, distributions, and clearance of intravenously injected GO-PEG nanoparticles in the blood vessel of mice could be observed clearly by two-photon imaging. The 3D distribution of microinjected GO-PEG nanoparticles in a mice brain could also be reconstructed with two-photon microscopy.
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