Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

A series of chromone and donepezil hybrids were designed, synthesized, and evaluated as multipotent cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors for the potential therapy of Alzheimer's disease (AD). studies showed that the great majority of these compounds exhibited potent inhibitory activity toward BuChE and AChE and clearly selective inhibition for MAO-B. In particular, compound presented the most balanced potential for ChE inhibition (BuChE: IC = 5.

A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer's disease.

The formation of amyloid-β (Aβ) plaques in the brain is one of the main pathological features of Alzheimer's disease (AD). The imaging probes, capable of detecting Aβ deposition, are important tools for early diagnosis of AD. In this article, we designed, synthesized and evaluated a cyanine-based near-infrared fluorescence (NIRF) probe ZT-1 for the detection of Aβ deposits in the brain.

Measuring upper limb movement to analyze intra-body communication channel attenuation characteristics.

Background: This experiment was designed to study the respective effects of the closed-state human palm and dynamic arm bending on intra-body communication channel attenuation.

Methods: We selected the right upper arm of a healthy adult male as the experimental object to measure channel attenuation variation in a closed or open palm, and when the arm was bent, so as to analyze channel characteristics.

Conclusions: The experiment showed that, in a quasi-static stable system, the effects of a closed palm on channel attenuation were negligibly minimal.

Modeling of sectionally continuous communication channel with inhomogeneously distributed tissues.

Background: This study aimed to investigate effects on the transmission channel caused by heterogeneous distribution in tissues and joint characteristics.

Method: Human arm section scans were taken using CT technology, and zoned, following which, a circumference measurement experiment was performed to analyze the effect of inhomogeneous distribution of tissues. In order to analyze the arm joint's effect on channel transmission, we proposed a piecewise modeling method in combination with connection conditions.