Clinical Predictors and Prevalence of Enteral Nutrition Intolerance in Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis.

Acute pancreatitis (AP) leads to severe inflammation and nutritional deficits, with 80% of severe cases experiencing critical protein loss. Timely enteral nutrition is essential for recovery. This study systematically reviews and analyzes the incidence and predictors of enteral nutrition intolerance (ENI) in AP patients.

Predictive Value of Serum sIL-2R Levels and Th17/Treg Immune Balance for Disease Progression in Patients With Rheumatoid Arthritis-Associated Interstitial Lung Disease.

Background: This article analyzed the relationship between serum sIL-2R levels and Th17/Treg immune balance in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and their prognostic value.

Methods: RA patients (n = 311) were retrospectively selected for research and then allocated to the RA and RA-ILD groups. Baseline data and 3-year follow-up records of all patients were attained to assess disease progression.

Lattice QCD Calculation of the Subtraction Function in Forward Compton Amplitude.

The subtraction function plays a pivotal role in calculations involving the forward Compton amplitude, which is crucial for predicting the Lamb shift in muonic atoms, as well as the proton-neutron mass difference. In this Letter, we present a lattice QCD calculation of the subtraction function using two domain wall fermion gauge ensembles near the physical pion mass. We utilize a recently proposed subtraction point, demonstrating its advantage in mitigating statistical and systematic uncertainties by eliminating the need for ground-state subtraction.

Association between multimorbidity and having less than 20 natural teeth among Chinese older adults: a cross-sectional study.

Understanding the impact of multimorbidity on having less than 20 natural teeth is crucial for safeguarding the oral health of older adults with multimorbidity. This study aimed to analyze the association between multimorbidity and having less than 20 natural teeth in older Chinese adults. The data for this analysis were obtained from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), which covers 23 provinces, municipalities, and autonomous regions throughout China.

BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance.

Extrachromosomal circular DNA (ecDNA) are commonly produced within the nucleus to drive genome dynamics and heterogeneity, enabling cancer cell evolution and adaptation. However, the mechanisms underlying ecDNA biogenesis remain poorly understood. Here using genome-wide CRISPR screening in human cells, we identified the BRCA1-A and the LIG4 complexes mediate ecDNA production.

An fNIRS Study of the Effects of Sound in Real Scenes on Joint Attention among Individuals With Autistic Traits in China.

There is no consensus on whether adult with autistic traits joint attention (JA) deficits. Additionally, previous studies have mostly been conducted in traditional laboratory settings, lacking ecological validity. This study aimed to address these limitations by using real-life scenarios and functional near-infrared spectroscopy (fNIRS) techniques to investigate the impact of sound cues on JA among individuals with Autistic Traits in China.

Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.

Cell death-based therapies combined with immunotherapy have great potential in cancer therapy. To further explore and apply the combined therapies, the immunogenicity of different cell death modes in colorectal cancer (CRC) was evaluated by a cause-and-effect framework encompassing 12 cell death modes. Results show robust correlations among cuproptosis, immunogenic cell death (ICD) and immunity in CRC, as observed in our in-house and other independent cohorts, which are substantiated by in vitro and in vivo experiments.

Digital pathways to healthcare: a systematic review for unveiling the trends and insights in online health information-seeking behavior.

The importance of seeking online health information cannot be overstated when addressing public health concerns. Researchers must comprehensively review the literature on online health information seeking to fully comprehend the underlying behaviors and trends that shape this phenomenon. This systematic review utilizes bibliometric methodologies and the scientometric software CiteSpace to thoroughly analyze journals from the Web of Science core collection database ( = 2,761), providing the theoretical groundwork for future research in this field.

Regulating Bifacial Surface Potential of Perovskite Film Enables Efficient Perovskite Solar Cells Universal for Different Charge Transport Layers.

Planar perovskite solar cells (PSCs) show huge promise as an efficient photovoltaic technology, where the inefficient carrier transport at the hetero-interface largely limits their performance advancement. Herein, bifacial surface potential regulation is realized in a monolithic perovskite film through interface doping, leading to optimized dual-interfacial energy level alignment. In a n-i-p planar device, the up-shift of Fermi level on the perovskite bottom surface is first achieved through bottom-up diffusion of Li.

Risk prediction models for post-intensive care syndrome of ICU discharged patients: A systematic review.

Objectives: This systematic review aimed to assess the properties and feasibility of existing risk prediction models for post-intensive care syndrome outcomes in adult survivors of critical illness.

Methods: As of November 1, 2023, Cochrane Library, PubMed, Embase, CINAHL, Web of Science, PsycInfo, China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang database, and China Science and Technology Journal Database (VIP) were searched. Following the literature screening process, we extracted data encompassing participant sources, post-intensive care syndrome (PICS) outcomes, sample sizes, missing data, predictive factors, model development methodologies, and metrics for model performance and evaluation.

A three-site recognition cytosensor for accurate detection of circulating tumor cells based on novel branched Pt Au nanospheres and MnO-GO-Au nanosheets.

A novel electrochemical cytosensor was developed with a three-protein recognition strategy, employing branched Pt Au nanospheres (B-Pt-Au NPs) as tags and MnO-GO-Au nanosheet-modified electrodes for circulating tumor cells (CTC) detection. This system integrates specific magnetic separation and CTC enrichment with sensitive electrochemical detection to identify rare A549 cells in whole blood. MnO-GO-Au nanosheets, known for their high conductivity and biocompatibility, were used to modify a bare electrode, improving the electrochemical interface for biomolecules.

The role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis.

The immune response goes haywire during sepsis. The aim of this study was to explore the role of CD57+γδ T cells in the immune pathogenesis of sepsis. We characterized the transcriptomic profile of peripheral γδ T cells obtained from patients with sepsis using the Smart RNA-Sequence.

Erwinia aeris sp. nov., A Novel Bacterium Isolated from the Surface of an Ore in Hubei Province, China.

A novel Gram-stain-negative, phosphate-solubilizing and siderophore producing bacterium, which we designated as strain ACCC 02193, was separated from ore, collected in Zhongxiang, Hubei of China. Phylogenetic analysis based on 16S rRNA gene sequences showed strain ACCC 02193 is in the genus Erwinia and had highest similarities to Erwinia tasmaniensis DSM 17950 (99.32%) and Erwinia billingiae DSM 17872 (98.

Odd dipole screening in radial inflation.

The inflation of an inner radial (or spherical) cavity in an amorphous solid confined in a disk (or a sphere) served as a fruitful case model for studying the effects of plastic deformations on the mechanical response. It was shown that when the field associated with Eshelby quadrupolar charges is nonuniform, the displacement field is riddled with dipole charges that screen elasticity, reminiscent of Debye monopoles screening in electrostatics. In this paper we look deeper into the screening phenomenon, taking into account the consequences of irreversibility that are associated with the breaking of Chiral symmetry.

Live-Cell Single-Molecule Imaging of Influenza A Virus-Receptor Interaction.

Influenza A viruses are a major health care burden, and their biology has been intensely studied for decades. However, many details of virus infection are still elusive, requiring the development of refined and advanced technologies. Super-resolution microscopy allows the study of virus replication at the scale of an infecting virus, offering an exciting perspective on previously unseen mechanistic details of infection.

Prognostic models of immune-related cell death and stress unveil mechanisms driving macrophage phenotypic evolution in colorectal cancer.

Background: Tumor microenvironment (TME), particularly immune cell infiltration, programmed cell death (PCD) and stress, has increasingly become a focal point in colorectal cancer (CRC) treatment. Uncovering the intricate crosstalk between these factors can enhance our understanding of CRC, guide therapeutic strategies, and improve patient prognosis.

Methods: We constructed an immune-related cell death and stress (ICDS) prognostic model utilizing machine learning methodologies.

The divergent reactivity of β-diketiminato aluminium hydrides with organophosphoryl compounds.

The reactions of LAlH (L = HC(CMeNAr), Ar = 2,6-PrCH) (1) with diphenylphosphane oxide [PhP(O)H], diphenylphosphinamide [PhP(O)NH], and diaryl/alkyl phosphane [(RO)P(O)H (R = Ph, or Pr)] afford their corresponding compounds with compositions LAl(H)OP(Ph) (2), LAl[OP(Ph)] (3), LAl{[N(H)P(O)(Ph)][OP(Ph)]} (4), LAl(OPr) (5), and LAl(OPh) (6), respectively. These reactions probably undergo a process of dehydrogenation coupling, deaminating dehydrogenation coupling, or chain-breaking coupling. It is noteworthy to mention that the reaction of compound 1 with 2 equiv.

c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in .

The universal bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) plays critical roles in regulating a variety of bacterial functions such as biofilm formation and virulence. The metabolism of c-di-GMP is inversely controlled by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs). Recently, increasing studies suggested that the protein-protein interactions between DGCs/PDEs and their partners appear to be a common way to achieve specific regulation.

First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial.

Programmed cell death protein-1 (PD-1) inhibitors plus chemotherapy have been the standard of care in the first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma; however, the survival benefits are modest in patients with low programmed death ligand 1 (PD-L1) expression. Here we investigated the efficacy and safety of cadonilimab (PD-1/cytotoxic T lymphocyte antigen-4 (CTLA-4) bispecific antibody) plus chemotherapy as first-line treatment in G/GEJ adenocarcinoma. The prespecified interim analysis is reported here.

Self-gripping versus polypropylene mesh for incisional hernia repair in a rat model.

Background: Self-gripping mesh, made of monofilament polypropylene and covered by a layer of polylactic acid micro-hooks, is applied in ventral hernia repair, whereas cytological change and collagen expression around the mesh are rarely reported. The objective of this research was to compare inflammatory response and collagen proliferation between self-gripping and polypropylene mesh in rat model of incisional hernia.

Methods: Forty-five rats were randomly divided into unrepaired (UR) group, polypropylene (PP) mesh group, and self-gripping (SG) mesh group and euthanized at 1, 2 and 4 weeks postoperatively.

Optimising Luteinising Hormone Levels on Trigger Day for Improved Ovarian Response and Pregnancy Outcomes in Gonadotropin-Releasing Hormone Antagonist Protocols: A Retrospective Cohort Study.

Objective: To determine the optimal luteinising hormone (LH) level on the trigger day and its impact on pregnancy outcomes in gonadotropin-releasing hormone (GnRH) antagonist protocols using a data-driven approach.

Design: Retrospective cohort study.

Setting: Third Affiliated Hospital of Guangzhou Medical University.

Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization.

Background: Previous clinical studies have suggested an increased risk of tumor development in patients with pulmonary arterial hypertension (PAH). However, it remains unclear whether there is a causal relationship between PAH and tumor occurrence. This study investigates the causal link between PAH and cancer from a genetic perspective using Mendelian randomization (MR).

Densely distributed Co onto carbon-layer-coated flower-like Ni/AlO and its tailored integration into a stirrer for multiple catalytic degradation and solar-powered water evaporation.

Multiple functional tailored materials have shown great potential for both pollutant degradation and freshwater recovery. In this study, we synthesized densely distributed Co onto carbon-layer-coated Ni/AlO hydrangea composites (Ni/AlO@Co) the polymerization of dopamine under a controlled graphitized process. The characterization results revealed that Ni/AlO@Co, with abundant exposed bimetallic Co-Ni species on the surface of AlO, could afford accessible catalytic sites for persulphate activation and subsequent pollutant degradation.

Mechanisms and therapeutic targets of mitochondria in the progression of metabolic dysfunction-associated steatotic liver disease.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) includes liver disease processes from simple fatty liver to nonalcoholic steatohepatitis, which may progress to liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). As the incidence of HCC derived from viral hepatitis decreases, MASLD has emerged as a significant health threat, driven by lifestyle changes and rising obesity rates among patients. The pathogenesis of MASLD is complex, involving factors such as insulin resistance, gut microbiota imbalance, and genetic and epigenetic factors.