Inclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study.

Background: Hypocretin-1 is a vital neurotransmitter in regulating the sleep-wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke.

Methods: A total of 183 consecutively elderly patients were included in the prospective cohort study.

Development of an AI model for predicting hypoxia status and prognosis in non-small cell lung cancer using multi-modal data.

Background: Prognosis prediction is crucial for non-small cell lung cancer (NSCLC) treatment planning. While tumor hypoxia significantly impacts patient outcomes, identifying hypoxic genomic markers remains challenging. This study sought to identify hypoxic computed tomography (CT) radiomic features and create an artificial intelligence (AI) model for NSCLC through the integration of multi-modal data.

Minimally invasive prone lateral retropleural or retroperitoneal antepsoas approach spinal surgery using the rotatable radiolucent Jackson table.

Background: Prone lateral spinal surgery for simultaneous lateral and posterior approaches has recently been proposed to facilitate surgical room efficiency. The purpose of this study is to evaluate the feasibility and outcomes of minimally invasive prone lateral spinal surgery using a rotatable radiolucent Jackson table.

Methods: From July 2021 to June 2023, a consecutive series of patients who received minimally invasive prone lateral spinal surgery for various etiologies by the same surgical team were reviewed.

Efficient and Rapid Enrichment of Extracellular Vesicles Using DNA Nanotechnology-Enabled Synthetic Nano-Glue.

Swift and efficient enrichment and isolation of extracellular vesicles (EVs) are crucial for enhancing precise disease diagnostics and therapeutic strategies, as well as elucidating the complex biological roles of EVs. Conventional methods of isolating EVs are often marred by lengthy and laborious processes. In this study, we introduce an innovative approach to enrich and isolate EVs by leveraging the capabilities of DNA nanotechnology.

Automated Incidental Findings Notification Through the Electronic Health Record Utilizing Dictation Macros.

The objective of this study is to implement an actionable incidental findings (AIFs) communication workflow integrated into the electronic health record (EHR) using dictation macros to improve the quality of radiology reports and facilitate delivery of findings to clinicians. The workflow was implemented across an academic multi-hospital health system and used by over 100 radiologists from 12 divisions. Standardized macros were created for different organ systems including the thyroid, lungs, liver, pancreas, spleen, kidney, female reproductive, and others, designed based on the ACR Novel Quality Measure Set.

The chain mediating role of social support and coping strategy: Type D personality and psychological distress among Chinese COPD patients.

This study examines how coping strategies and social support mediate the relationship between type D personality and psychological distress in COPD patients. A sample of 351 patients completed surveys on demographics, psychological distress (Kessler Psychological Distress Scale), social support (Social Support Self-Rating Scale), coping strategies (Chinese version of Medical Coping Modes Questionnaire), and type D personality (Type D Personality Scale). Using structural equation modeling (SEM) via AMOS 23.

Integrating Metabolomics and Transcriptomics to Analyse and Reveal the Regulatory Mechanisms of Mung Bean Polyphenols on Intestinal Cell Damage Under Different Heat Stress Temperatures.

Background/objectives: Polyphenols represent a new strategy of dietary intervention for heat stress regulation.

Methods: The metabolic and genetic effects of three heat stress-regulated mung bean polyphenols on mouse small intestinal epithelial Mode-k cells were investigated by metabolomics-transcriptomics correlation analysis at different heat stress levels.

Results: Lipid metabolism, energy metabolism, and nervous system pathways were the key metabolic regulatory pathways.

Integrated Transcriptome and Metabolome Analysis Reveals the Resistance Mechanisms of Against .

Rapeseed ( L.) is an important crop for healthy edible oil and stockfeed worldwide. However, its growth and yield are severely hampered by black rot, a destructive disease caused by pv.

Mechanical Properties and Microstructure of Geopolymer-Based PFSS Synthesized from Excavated Loess.

Pre-mixed fluidized solidified soil (PFSS) has the advantages of pumpability, convenient construction, and a short setting time. This paper took the excavated loess in Fuzhou as the research object and used cement-fly-ash-ground granulated blast furnace slag-carbide slag as a composite geopolymer system (CFGC) to synthesize PFSS. This study investigated the fluidity and mechanical strength of PFSS under different water-solid ratios and curing agent dosages; finally, the microstructure of the composite geopolymer system-pre-mixed fluidized solidified soil (CFGC-PFSS) was characterized.

Integrated Metabolomics and Transcriptome Analysis of Anthocyanin Biosynthetic Pathway in .

is an important landscape tree species whose flower color has high ornamental value. However, the molecular mechanisms regulating flower color in remain unclear. By studying the metabolomics and transcriptomics of three different color varieties under the species lineage of , 'Eigeng' (EG, white), 'Albo-rosea' (AR, pink), and 'Grandiflora' (GF, green), the biosynthetic mechanisms of different flower colors in were revealed.

The mechanism of alkali to inhibit the organics polymerization in improving the biodegradability of wastewater treated by heat/peroxydisulfate.

High-temperature wastewaters can themselves activate peroxydisulfate (PDS) to remove aromatic contaminants via polymerization. This, however, may result in an insufficient carbon source for denitrification during biochemical treatment, and the formed polymers, without a proper reuse method, will be costly to handle as hazardous waste. This study demonstrates that the addition of NaOH can suppress the polymerization of aromatic contaminants, which is observed not only in simulated wastewater but also in actual coking wastewater (ACW).

Head pose-assisted localization of facial landmarks for enhanced fast registration in skull base surgery.

In skull base surgery, the method of using a probe to draw or 3D scanners to acquire intraoperative facial point clouds for spatial registration presents several issues. Manual manipulation results in inefficiency and poor consistency. Traditional registration algorithms based on point clouds are highly dependent on the initial pose.

Platelet-Rich Plasma Versus Corticosteroids in the Treatment of Plantar Fasciitis: A Systematic Review and Meta-Analysis.

Objective: This study aims to compare the efficacy of platelet-rich plasma (PRP) and corticosteroids (CS) in treating plantar fasciitis, focusing on pain relief, foot function, and plantar fascia thickness to identify the optimal treatment approach.

Design: A comprehensive search of medical databases was conducted following PRISMA guidelines, utilizing an extensive keyword strategy. Inclusion criteria encompassed prospective RCTs involving adult patients with plantar fasciitis treated with local PRP or CS injections, specifically assessing outcomes such as the Visual Analogue Scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) scores, and plantar fascia thickness.

Association between auditory mismatch negativity and visual working memory in school-age children with attention deficit/hyperactivity disorder.

Background: Attention-deficit/hyperactivity disorder (ADHD) patients exhibit characteristics of impaired working memory (WM) and diminished sensory processing function. This study aimed to identify the neurophysiologic basis underlying the association between visual WM and auditory processing function in children with ADHD.

Methods: The participants included 86 children with ADHD (aged 6-15 years, mean age 9.

Increased antimicrobial resistance of isolates obtained from children in Beijing, China, in 2023.

Introduction: (), a common pathogen of community-acquired pneumonia in school-age children and adolescents, can cause epidemics worldwide. In late 2023, the incidence of infection among children reached a high level.

Methods: We investigated the antimicrobial susceptibility of 62 isolates obtained from children with pneumonia in Beijing between 2021 and 2023, and analyzed the correlation of antimicrobial susceptibility with molecular characteristics of isolates and clinical manifestations of patients.

The first case of esophageal mediastinal fistula after immunotherapy for non-small cell lung cancer: case report and literature review.

Background: Malignant esophageal mediastinal fistula is a severe complication that occurs in both the advanced stages of esophageal cancer and after radiotherapy for esophageal cancer. Esophageal mediastinal fistula is very susceptible to complications such as mediastinitis and mediastinal abscess, resulting in a significantly elevated mortality rate for patients. We reported a rare case of esophageal mediastinal fistula after immunotherapy for non-small cell lung cancer (NSCLC).

High-alcohol-producing Klebsiella pneumoniae aggravates lung injury by affecting neutrophils and the airway epithelium.

We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover that 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory disease severity.

Gene Associated with Breast Cancer: A Genetic and Bioinformatic Study.

Female breast cancer is the most common and the fifth deadliest cancer worldwide. It is influenced by a combination of genetic, hormonal, and environmental factors. The excision repair cross-complementation group 3 gene () has recently been identified as a breast cancer susceptibility gene in various cohorts of different geographical and ethnic origin.

Impaired visual attention and numerical processing in children with anisometropic amblyopia and after visual acuity recovery.

Amblyopia affects more than visual acuity. To compare the performances of visual selective attention and numerical processing in children with anisometropic amblyopia and children with normal vision, and investigate whether performance would be improved after visual acuity recovery, we performed 3 visual attention tasks (identifying number location task, numerical comparison task, and specific number comparison task) in children with anisometropic amblyopia, children who had recovered from anisometropic amblyopia, and children with normal vision in 6-8 and 9-11 years groups. The numerical processing ability, visual selective attention, and numerical distance effect were assessed by their reaction time of different tasks.

Restorative Effects of Short-Chain Fatty Acids on Corneal Homeostasis Disrupted by Antibiotic-Induced Gut Dysbiosis.

The gut microbiota plays a crucial regulatory role in various physiological processes, yet its impact on corneal homeostasis remains insufficiently understood. Here, we investigate the effects of antibiotic-induced gut dysbiosis (AIGD) and germ-free conditions on circadian gene expression, barrier integrity, nerve density, and immune cell activity in the corneas of mice. Through RNA sequencing, we found that both AIGD and germ-free conditions significantly disrupted the overall transcriptomic profile and circadian transcriptomic oscillations in the cornea.

Evaluation the protective role of baicalin against HO-driven oxidation, inflammation and apoptosis in bovine mammary epithelial cells.

Mastitis is one of the most common diseases in dairy farms. During the perinatal period, the bovine mammary epithelial cells (BMECs) of High-yielding dairy cows accelerate metabolism and produce large amounts of reactive oxygen species (ROS). It is one of the primary causes of mastitis and will lead to the breakdown of redox balance, which will induce oxidative stress, inflammation, and apoptosis.

Transurethral Cylindrical Water Sac Prostate Enlargement Surgery for the Treatment of Small-Volume Benign Prostatic Hyperplasia: A Retrospective Analysis.

Aim: To investigate the clinical efficacy of transurethral columnar balloon dilation of prostate (TUCBDP) in the treatment of small-volume benign prostatic hyperplasia (BPH) and provide the optimal treatment for the surgical treatment of small volume benign prostatic hyperplasia.

Methods: This retrospective study analyzed 106 patients with small-volume BPH who underwent surgical treatment at the Department of Urology, Xiangya Changde Hospital from December 2023 to January 2024. The patients were divided into two groups based on the type of surgery received: TUCBDP group (n = 53) and transurethral resection of prostate (TURP) group (n = 53), which serves as the control group.

[Therapeutic effect of joint injection of platelet-rich plasma combined with shock wave on osteochondral injury of talus].

Objective: To explore clinical efficacy of platelet rich plasma (PRP) injection combined with extracorporeal shock wave therapy (ESWT) in treating osteochondral lesion of talus (OLT) with typeⅡa.

Methods: From January 2022 to June 2022, 45 patients with typeⅡa OLT were treated with PRP arthroscopic injection combined with ESWT, including 29 males and 16 females; aged from 18 to 63 years old with an average of(37.7±10.

Exploring the Prognostic Value of Tumour-Associated Genes in Clear Cell Renal Cell Carcinoma Through Single-Cell RNA Sequencing Insights.

Clear cell renal cell carcinoma (ccRCC) characterised by its diversity and a tendency to defy standard therapeutic approaches. Amidst the advent of immunotherapy, it has become imperative to pinpoint prognostic indicators of the tumour microenvironment (TME) influence the efficacy of treatments. Employing single-cell RNA sequencing (scRNA-seq), this research delved into the diverse landscape of ccRCC, uncovering its complex underpinnings and pinpointing molecular avenues for therapeutic intervention.