Publications by authors named "Fu Rong Kou"
Analysis of actionable gene fusions in a large cohort of Chinese patients with colorectal cancer.
Gastroenterol Rep (Oxf)
October 2024
Article Synopsis
- The study investigated the occurrence of actionable gene fusions in a large group of colorectal cancer (CRC) patients from China, analyzing data from 5,534 patients.
- Findings revealed that only 0.98% (54 patients) had actionable gene fusions, with one specific fusion being the most common (38.9% of fusions).
- The prevalence of these fusions was notably higher in patients with microsatellite instability-high (MSI-H) and in colon cancer compared to rectal cancer, suggesting that specific genetic markers can enhance fusion detection rates for better clinical decision-making.
Background: Signet ring cell carcinoma (SRCC) is an uncommon subtype in colorectal cancer (CRC), with a short survival time. Therefore, it is imperative to establish a useful prognostic model. As a simple visual predictive tool, nomograms combining a quantification of all proven prognostic factors have been widely used for predicting the outcomes of patients with different cancers in recent years.
View Article and Find Full Text PDFA simple and specific, rapid resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for determination of chlorogenic acid in human plasma using neochlorogenic acid as the internal standard. Plasma samples were precipitated with methanol and separated on a Zorbax C18 column (50 × 2.1 mm, i.
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