Publications by authors named "Fu Qian"

Butachlor is a widely utilized acetamide herbicide noted for its systemic selectivity against pre-emergence grass weeds. Butachlor has negative effects on organisms and the environment, so it is necessary to screen degradation strains. In this investigation, strain DC-1 was isolated from soil persistently exposed to butachlor.

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Background: Health inequality caused by the scarcity and uneven distribution of paediatric service resources is common worldwide. The hospital strategic alliance may improve paediatric service capacity and health equity, but this hypothesis has not yielded consistent results. Here, we examine the hospital strategic alliance's effect on local hospitals' paediatric service capacity.

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Article Synopsis
  • * DEX can be administered in various ways during and after surgery, but studies show inconsistent results regarding its effectiveness on sleep.
  • * Future research directions are needed to better understand how DEX affects postoperative sleep and to clarify the mechanisms at play, which could inform the design of upcoming studies.
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Cellulose nanocrystal (CNC) is a sustainable bio-nanomaterial. The distinctive left-handed polarization properties render cellulose nanocrystal a promising candidate for optical film. Due to eco-friendliness, reliability, mildness and simplicity, the oxalate hydrolysis method stands out among various preparation methods for CNC.

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Objectives: Effectiveness of nirmatrelvir/ritonavir (NR) in kidney transplant recipients (KTRs) infected COVID-19 for more than 5 days has not been evaluated.

Methods: In this multicenter retrospective study, 85 KTRs with COVID-19 were enrolled, including 50 moderate, 21 severe, and 14 critical patients.

Results: The median time from onset to starting NR treatment was 14 (IQR, 11-19) days.

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Objective: To comprehensively and quantitatively evaluate the impact of body weight support training (BWST) on balance and gait function in stroke patients based on an evidence-based basis and to identify the most effective intervention strategies.

Methods: PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang, and Chinese SinoMed Database were searched until November 25, 2023. Quality assessment and meta-analysis were performed using RevMan 5.

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  • Cancer metastasis, driven by increased glycolysis, is the leading cause of cancer-related deaths, and targeting aerobic glycolysis may be an effective strategy for treatment.
  • Non-coding RNAs (ncRNAs) like microRNAs, long noncoding RNAs, and circular RNAs play vital roles in modulating glycolysis and influencing tumor spread by acting as competitive endogenous RNAs (ceRNAs).
  • The article discusses how signaling pathways and transcription factors contribute to glycolysis in metastasis, as well as the potential for ncRNAs and traditional medicine to serve as prognostic markers or new anti-cancer treatments.
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Objective: Tacrolimus (TAC) is a first-line immunosuppressant to prevent allograft rejection. tablet is widely used as a TAC-sparing agent in China that could significantly elevate TAC exposure. However, insufficient data support the dose recommendation of TAC when co-administered with .

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  • Safety decisions at intersections require real-time assessment of vehicle-pedestrian risks, with current models suffering from inaccuracies due to their ideal assumptions and reliance on interaction points.
  • This study introduces a new model that focuses on driver-pedestrian interaction preferences and defines key concepts like 'driving risk index' and 'driving risk gradient' to improve safety assessments.
  • By using trajectory data from multiple intersections, the proposed Vehicle-Pedestrian Interaction Risk (VPIR) model demonstrates better accuracy than traditional surrogate models and effectively evaluates risks in diverse scenarios, aiding advancements in autonomous driving safety.
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Currently, clinical therapeutic strategies for nasopharyngeal carcinoma (NPC) confront insurmountable dilemmas in which surgical resection is incomplete and chemotherapy/radiotherapy has significant side effects. Phototherapy offers a maneuverable, effective, and noninvasive pattern for NPC therapy. Herein, we developed a lysosome-targeted and pH-responsive nanophototheranostic for near-infrared II (NIR-II) fluorescence imaging-guided photodynamic therapy (PDT) and photothermal therapy (PTT) of NPC.

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Enlarging the lateral space of drip tubes saves irrigation equipment costs (drip tubes and bypass), but it will lead to an increased risk of grain yield heterogeneity between wheat rows. Adjusting wheat row spacing is an effective cultivation measure to regulate a row's yield heterogeneity. During a 2-year field experiment, we investigated the variations in yield traits and photosynthetic physiology by utilizing two different water- and fertilizer-demanding spring wheat cultivars (NS22 and NS44) under four kinds of drip irrigation patterns with different drip tube lateral spacing and wheat row spacing [① TR4, drip tube spacing (DTS) was 60 cm, wheat row horizontal spacing (WRHS) was 15 cm; ② TR6, DTS was 90 cm, WRHS was 15 cm; ③ TR6L, DTS was 90 cm, WRHS was 10 cm, inter-block spacing (IBS) was 35 cm; and ④ TR6S, DTS was 80 cm, WRHS was 10 cm, IBS was 25 cm].

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  • Diabetic encephalopathy (DE) is a serious brain complication linked to diabetes, and this study looked at how mTOR regulates NF-κB in mice with DE and the effects of luteolin, a natural compound with neuroprotective properties.
  • Luteolin treatment improved cognitive impairment in the mice, reduced levels of certain proteins related to inflammation and stress response, and increased beneficial brain proteins.
  • The study suggests that luteolin might help protect against DE by inhibiting HDAC2 and regulating mTOR/NF-κB signaling, ultimately reversing the negative effects on brain health and cognition.
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  • Regorafenib is a multikinase inhibitor approved for treating metastatic colorectal cancer (mCRC), but its high cost raises concerns about cost-effectiveness compared to other treatments.!* -
  • The study thoroughly reviewed literature to assess the cost-effectiveness of regorafenib against various third-line therapies, including TAS-102 and best supportive care, finding that regorafenib's standard dosing is less cost-effective.!* -
  • The findings suggest that regorafenib is not the most economical option for mCRC treatment, but optimizing its dosage could improve its cost-effectiveness among other therapies.!*
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Objectives: To describe the pharmacokinetic (PK) characteristics of nirmatrelvir/ritonavir in renal transplant recipients and explore the potential factors that related to the PK variance of nirmatrelvir/ritonavir and its interaction with calcineurin inhibitor (CNI).

Methods: Renal transplant recipients treated with CNI and nirmatrelvir/ritonavir were prospectively enrolled. Steady-state plasma concentrations of nirmatrelvir/ritonavir were determined by high-performance liquid chromatography-tandem mass spectrometry, and the PK parameters were calculated using non-compartmental analysis.

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The efficient and stable production of hydrogen (H) through Pt-containing photocatalysts remains a great challenge. Herein, we develop an effective strategy to selectively and uniformly anchor Pt NPs (∼1.2 nm) on a covalent triazine-based framework photocatalyst derived bridging ligands.

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Background: No study has validated, compared and adapted scoring systems for prognosis prediction based on donor kidney core biopsy (CB), with less glomeruli than wedge biopsy.

Methods: A total of 185 donor kidney CB specimens were reviewed using seven scoring systems. The association between the total score, item scores, score-based grading, and allograft prognosis was investigated.

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Dechlorination of chloropyridines can eliminate their detrimental environmental effects. However, traditional dechlorination technology cannot efficiently break the C-Cl bond of chloropyridines, which is restricted by the uncontrollable nonselective species. Hence, we propose the carbonate species-activated hydrogen peroxide (carbonate species/HO) process wherein the selective oxidant (peroxymonocarbonate ion, HCO) and selective reductant (hydroperoxide anion, HO) controllably coexist by manipulation of reaction pH.

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Due to marvelous sensitivity and flexibility, conductive hydrogels are popularly used as strain sensors in intelligent skin and wearable electronic devices fields. However, hydrogel tends to be destroyed after long-term use or in accident, leading to performance degradation. Herein, we developed an environmental-friendly Ti-containing conductive hydrogel.

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The utility of electrochemical active biofilm in bioelectrochemical systems has received considerable attention for harvesting energy and chemical products. However, the slow electron transfer between biofilms and electrodes hinders the enhancement of performance and still remains challenging. Here, using FeO /L-Cys nanoparticles as precursors to induce biomineralization, a facile strategy for the construction of an effective electron transfer pathway through biofilm and biological/inorganic interface is proposed, and the underlying mechanisms are elucidated.

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Zinc oxide nanoparticles (ZnO NPs) have emerged as a novel solution to combat Zn deficiency in agriculture. However, challenges persist regarding their Zn utilization efficiency and environmental impact. Fulvic acid (FA), as a relatively mature modified material, is a promising candidate to enhance the environmental stability of ZnO NPs.

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In this paper, an eco-friendly versatile superabsorbent material was designed for soil improvement, and a synchronous chemical loading strategy was proposed. In this strategy, urea not only acted as fertilizer but also acted as a crosslinker to construct an alginate network. The microstructure, chemical structure, thermal stability and composition of the obtained SA/urea hydrogel were characterized in detail.

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Although antibacterial platforms involving nanozymes have been extensively investigated, there are still problems of poor reactive oxygen species generation efficiency and obstinate bacterial biofilms. Developing a nanozyme-photothermal therapy nanoplatform with superior sterilization effects and minimal side effects would be a good alternative for completely eliminating bacteria and biofilms. Herein, an ultrathin PdMo bimetallene nanozyme with a planar topology and boosted metal utilization, exhibiting excellent photothermal and peroxidase-like activity, is designed for synergistic nanozyme-photothermal sterilization applications and accelerated wound healing.

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Microbial fuel cells (MFCs) are an emerging technology in renewable energy and waste treatment and the scale-up is crucial for practical applications. Undoubtedly, the analysis and comprehension of MFC operation necessitate essential information regarding the response of the current distribution to variable operating conditions, which stands as one of its significant dynamic characteristics. In this study, the dynamic responses of current distribution to external stimuli (external load, temperature, pH, and electrolyte concentration) were investigated by employing a segmented anode current collector in a liter-scale MFC.

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Background: In children with CKD, Protein Energy Wasting (PEW) is common, which affects the outcome of children and is an important cause of poor prognosis. We are aiming to explore the pathogenesis of muscle wasting in CKD-PEW children.

Methods: Blood samples of 32 children diagnosed with chronic kidney disease (CKD) and protein energy wasting (PEW) in our hospital from January 2016 to June 2021 were collected.

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