Intravenous immunoglobulin ameliorates doxorubicin-induced intestinal mucositis by inhibiting the Syk/PI3K/Akt axis and ferroptosis.

Background: Chemotherapy-induced mucositis (CIM) significantly impacts quality of life and reduces survival in patients treated with specific chemotherapeutic agents. However, effective clinical treatments for CIM remain limited. Intravenous immunoglobulin (IVIg), a therapeutic derived from pooled human plasma, is widely used to treat inflammatory diseases.

[Factors influencing the continued intention to use health science popularization WeChat accounts among university students in Chengdu in 2023].

Objective: Exploring factors influencing the continued use intention of health science popularization WeChat accounts among university students in Chengdu.

Methods: Stratified cluster random sampling was employed to select students from 10 universities in Chengdu in 2023 as research subjects, with data collected via a questionnaire. The questionnaire encompassed demographic information, usage patterns of health science popularization WeChat accounts, and factors influencing continued use intentions.

Invasive or Non-invasive Vagus Nerve Stimulation Modulation of Brain Function and Remodeling After Stroke: a Review.

Background: The main reason restricting stroke patients from reintegrating into society is neurological deficits. Of particular interest is the potential Vagus Nerve Stimulation (VNS) potentially offers for sustaining improvement in neurological deficits. The goal of the present study is to provide a summary of the findings from research that has been carried out to elucidate the mechanisms and demonstrate the efficacy and safety of the clinical application of VNS, as well as to identify research gaps in the field, in order to offer references for subsequent further research and application.

Adverse reactions associated with SSRIs and PD-1/PD-L1 inhibitors: a disproportionality analysis of the FDA adverse event reporting system.

Background: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination.

Establishment of a survival rabbit model for laryngotracheal stenosis: A prospective randomized study.

Objective: To develop a reproducible survival rabbit model for laryngotracheal stenosis (LTS).

Methods: Seventy New Zealand white (NZW) rabbits were randomly divided into experimental groups ( = 30) and a control group ( = 40). In experimental groups, a nylon brush was inserted retrograde from the tracheotomy through the subglottis and rotated until a full layer circumferential mucosal injury to cartilage exposure, assisted by fiberoptic laryngoscopy (FOL) visualization.

Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.

The presence of the Hepatitis B virus (HBV) is considered as a valuable risk factor of hepatocellular carcinoma (HCC). To more deeply comprehend the molecular mechanism and transcriptome of HBV-induced HCC, we utilized tandem mass tagging (TMT)-based quantitative proteomics analysis and whole-transcriptome sequencing to analyze three sets of matched HepG2 hepatoma cells and HBV-positive HepAD38 cells. The differentially expressed (DE) proteins (1596), mRNAs (5263), miRNAs (581), lncRNAs (2672) and circRNAs (222) were subjected to differential expression and enrichment analyses in order to thoroughly assess the gene-regulatory circuits of HBV-induced HCC.

Novel decision-level fusion strategies combined with hyperspectral imaging for the detection of soybean protein content.

Soybeans are used for human consumption or animal feed due to their abundant protein content. In this study, visible-near infrared (VNIR) hyperspectral imaging (HSI) and short-wave infrared HSI combined with three-levels data fusion methods were employed to detect the protein content of soybean seeds, including measurement-level fusion, feature-level fusion, and decision-level fusion. Additionally, three novel decision-level fusion methods were proposed, including binary linear regression, feature-based multiple linear regression (MLR), and model-based MLR.

Biogenic iron mineral formation and the fate of arsenic driven by its coupling with ferrous iron in acid mine drainage environment.

Acid mine drainage (AMD) containing arsenic produced during coal mining is a global environmental problem. However, the coupled driving process of the key element Fe and the associated element As in the AMD environment has received little attention. Therefore, in this study, we investigated the A.

The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.

Background: This study aims to evaluate the diagnostic and prognostic value of heparin-binding protein (HBP) in cerebrospinal fluid (CSF) for patients with intracranial infections.

Methods: This study included 211 subjects, of whom 138 were diagnosed with intracranial infections, 20 were patients with non-infectious inflammatory encephalopathies, and 53 controls who were eventually excluded from intracranial infections and inflammatory encephalopathies. The levels of HBP and procalcitonin (PCT) in CSF were detected in the subjects, and the diagnostic value of CSF HBP and PCT for intracranial infections was assessed using the receiver operating characteristic (ROC) curves.

Tracking the Changes of DOM Composition, Transformation, and Cycling Mechanism Triggered by the Priming Effect: Insights from Incubation Experiments.

The priming effect (PE) is recognized as an important mechanism influencing organic matter transformation in aquatic systems. The land-ocean aquatic continuum (LOAC) has received large quantities of dissolved organic matter (DOM) from various sources, which is an ideal interface for PE research. Here, we investigated the PE process by utilizing such a coastal environment to explore the turnover of DOM in the LOAC system.

Artificial Nanovesicles Derived from Cells: A Promising Alternative to Extracellular Vesicles.

As naturally secreted vesicles by cells, extracellular vesicles (EVs) play essential roles in modulating cell-cell communication and have significant potential in tissue regeneration, immune regulation, and drug delivery. However, the low yield and uncontrollable heterogeneity of EVs have been obstacles to their widespread translation into clinical practice. Recently, it has been discovered that artificial nanovesicles (NVs) produced by cell processing can inherit the components and functions of the parent cells and possess similar structures and functions to EVs, with significantly higher yields and more flexible functionalization, making them a powerful complement to natural EVs.

Quality Characteristics Changes of the Fat Portion of Chinese Bacon During Processing Based on Physicochemical Properties and Microstructure Studies.

In order to elucidate the development of quality properties in the fat portion of Chinese bacon during low-temperature smoking (LTS), raw pork was cured for five days, followed by infusion with smoked liquid and a subsequent ten-day smoking period characterized by alternating high and low-temperature conditions. The physicochemical characteristics and microstructures of the fat portion of the Chinese bacon were examined at three stages: the raw meat stage (Control), the curing stage (C3d and C5d), and the smoking stage (S5d and S10d). The results showed that LTS increased the hardness, transparency, and b* value of bacon fat.

The Influence of Dietary n-3 Highly Unsaturated Fatty Acids on Growth, Fatty Acid Profile, Lipid Metabolism, Inflammatory Response, and Intestinal Microflora in F Generation Female Yangtze Sturgeon ().

DHA and EPA, as indispensable n-3 highly unsaturated fatty acids (HUFAs), exert a fundamental influence on regulating fish growth, lipid metabolism, and overall well-being. However, there is a notable lack of data concerning their effects on the F female generation of Yangtze sturgeon. Over a ten-month period, this study assessed the impacts of various dietary concentrations of n-3 HUFAs (0.

Self-Assembled Pt/Honokiol Nanomicelles for the Treatment of Sepsis-Associated Acute Kidney Injury.

Sepsis is a severe and complex systemic infection that can result in multiple organ dysfunction. Sepsis-associated acute kidney injury (SAKI), caused by inflammatory response, oxidative stress, and cellular apoptosis, is a common complication that seriously impacts patient survival rates. Herein, a potent and novel metal-polyphenol nanomicelle can be efficiently self-assembled with Pt and honokiol (HK) by the chelation, π-π conjugation, hydrophobic action, and the surfactant properties of Tween-80.

Dominance of Plastic Emission in the High Arctic Aerosol in Light Spring.

Arctic haze has attracted considerable scientific interest for decades. However, limited studies have focused on the molecular composition of atmospheric particulate matter that contributes to Arctic haze. Our study collected atmospheric particles at Alert in the Canadian high Arctic from mid-February to early May 2000.

Life course patterns of work history and cognitive trajectories among community-dwelling older adults.

Objectives: Prior research indicated that diverse work experiences in early and middle life stages are associated with cognitive function in later life. However, whether life course patterns of work history are associated with later life cognitive function in China remains unknown.

Methods: Data were derived from the China Health and Retirement Longitudinal Study, and 5,800 participants aged 60 years or older were included.

Structural diversity of Alzheimer-related protein aggregations revealed using photothermal ratio-metric micro-spectroscopy.

The crucial link between pathological protein aggregations and lipids in Alzheimer's disease pathogenesis is increasingly recognized, yet its spatial dynamics remain challenging for labeling-based microscopy. Here, we demonstrate photothermal ratio-metric infrared spectro-microscopy (PRISM) to investigate the structural and molecular compositions of pathological features in brain tissues at submicron resolution. By identifying the vibrational spectroscopic signatures of protein secondary structures and lipids, PRISM tracks the structural dynamics of pathological proteins, including amyloid and hyperphosphorylated Tau (pTau).

Study of association between embryo growth arrest (EGA) and atmospheric fine particulate matter pollution (PM) and spatial metabolomics of villi derived from pregnant women.

Fine particulate matter (PM) is related to embryo growth arrest (EGA). In this study, we collected demographic information from EGA cases and early pregnancy controls in Taiyuan, China, between 2022 and 2023 and obtained villi and serum samples from these participants. We employed multilevel mixed-effects logistic regression models to estimate the odds ratios (ORs).

Structural Evolution and Electronic Properties of Neutral Boron-Doped Nitrogen Clusters.

Clusters represent intermediate states between isolated atoms and bulk solids. They serve as model systems to elucidate the physical properties of compounds from the atomic or molecular scale to the macroscopic bulk phase. Here, we perform thorough structure searches of neutral boron doped nitrogen clusters by Crystal structural anaLYsis by Particle Swarm Optimization (CALYPSO) cluster structural prediction and density functional theory (DFT) calculations.

Camrelizumab vs Placebo in Combination With Chemotherapy as Neoadjuvant Treatment in Patients With Early or Locally Advanced Triple-Negative Breast Cancer: The CamRelief Randomized Clinical Trial.

Importance: Preferred neoadjuvant strategies for early or locally advanced triple-negative breast cancer include a 4-drug chemotherapy regimen containing anthracyclines, cyclophosphamide, taxanes, and platinum. Blockade of the programmed death receptor 1/ligand-1 (PD-1/PD-L1) pathway may improve efficacy of classic neoadjuvant chemotherapy. Camrelizumab, an anti-PD-1 antibody, has showed antitumor activity in advanced triple-negative breast cancer.

Downregulated YTHDF2 expression in systemic lupus erythematosus is associated with inflammatory and neutrophil cytokine production.

Objectives: An increasing body of evidence suggests that N6-methyladenosine (m6A) plays a crucial role in the etiology of SLE. We focused on YTHDF2 expression in neutrophils and the relationship between YTHDF2 and the pathogenesis of SLE.

Methods: Sixty-one patients with SLE and 48 healthy controls (HC) were recruited, and their clinical characteristics were recorded.

Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013-2016.

Introduction: Population aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks, including associations with age-related diseases. This study investigates the relationship between EO exposure and biological age acceleration.

INSPIRE: Single-beam probed complementary vibrational bioimaging.

Molecular spectroscopy provides intrinsic contrast for in situ chemical imaging, linking the physiochemical properties of biomolecules to the functions of living systems. While stimulated Raman imaging has found successes in deciphering biological machinery, many vibrational modes are Raman inactive or weak, limiting the broader impact of the technique. It can potentially be mitigated by the spectral complementarity from infrared (IR) spectroscopy.

Vagal innervation limits brain injury by inhibiting gut-selective integrin-mediated intestinal immunocyte migration in intracerebral hemorrhage.

: The vagus nerve, which connects the brain and gastrointestinal tract, helps to maintain immune balance in the intestines. Gut-specific integrins, on the other hand, help to keep immune cells in the intestines. Since immune cells from outside the intestines can significantly affect the outcome of strokes, we investigated how immune cells from the intestines affect the immune response in the brain during intracerebral hemorrhage (ICH).