Precise manipulation of iron spin states in single-atom catalytic membranes for singlet oxygen selective production.

Heterogeneous single-atom catalysts are attracting substantial attention for selectively generating singlet oxygen (O). However, precise manipulation of atom coordination structures remains challenging. Here, the fine coordination structure of iron single-atom carbon-nitride catalysts (Fe-CNs) was manipulated by precisely tuning the heating rate with 1 °C min difference.

Association of PTOV1 and Cyfra21-1 with neoadjuvant chemosensitivity in patients with lung adenocarcinoma.

Objectives: This retrospective study mainly analyzed the relationship between prostate tumor overexpressed 1 (PTOV1) and cytokeratin 19 fragment (Cyfra21-1) and neoadjuvant chemosensitivity in patients with lung adenocarcinoma (LUAC).

Methods: A total of 110 LUAC patients who received neoadjuvant chemotherapy (cisplatin 75 mg/m combined with pemetrexed 500 mg/m) from February 2022 to February 2024 were selected. They were divided into a chemoresistant group (n=32) and a chemosensitive group (n=78) based on treatment response, and their clinical data were analyzed.

Efficient Targeted Regulation of the Interfaces and Bulk in Inverted Perovskite Solar Cells With a [closo-BH]-based Derivative.

The performance and stability of inverted perovskite solar cells (PSCs) is adversely affected by the recombination loss, ion migration, and residual stress arising from issues within the bulk and at the cathode interface. Using simple post-treatment with a novel solution-processable derivative of the dodecahydro-closo-dodecaborate anion ([closo-BH])-(TBA)[BH(OCHCH)OH] (TBAB)-it is simultaneously address these issues. In inverted PSCs, the cationic and anionic components of TBAB uniquely self-separate by positioning themselves precisely to perform their specific modification functions.

Preparation of a chitosan/polyvinyl alcohol-based dual-network hydrogel for use as a potential wound-healing material for the sustainable release of drugs.

Treating chronic wounds poses significant challenges in clinical medicine due to bacterial infection, reactive oxygen species (ROS) accumulation, and excessive inflammation. This study aimed to address these issues by developing a wound dressing with antibacterial, antioxidant, and anti-inflammatory properties. Chitosan was functionally modified with acrolein to covalently bind to epigallocatechin gallate (EGCG), enabling a high EGCG load.

Linearly Scaling Molecular Dynamic Modeling To Simulate Picosecond Laser Ablation of a Silicon Carbide Crystal.

A molecular dynamics model for picosecond laser ablation of nanoscale silicon carbide crystals was established by linearly scaling the laser focal diameter, and the correlation between the molecular dynamic simulation of the nanoscale and the experimental reproduction of the microscale was achieved. The calculation accuracy of the molecular dynamic model was verified by ablating the surface of silicon carbide wafers with a laser pulse width of 37 ps. On this basis, this paper further investigated the influence of the laser pulse width and fluence on the surface ablation damage and modification width, threshold, and lattice temperature.

[Clinical Application of Two Bleeding Scoring Scales in Children with Primary Immune Thrombocytopenia].

Objective: To explore the clinical application value of the Bleeding Scoring Scales (2019 Pediatric ITP Scale) in the diagnosis and treatment of children with primary immune thrombocytopenia (ITP).

Methods: A total of 422 children with ITP were evaluated with the 2019 Pediatric ITP Scale and the 2013 ITP-BAT and their clinical data were analyzed. The correlation between the two bleeding scoring scales and disease stage, platelet count was analysed, the evaluation time, consistency of the two bleeding scoring scales was compared, and the correlation of the two methods.

Heterogeneous Covalent Organic Framework Membranes Mediated by Polycations for Efficient Ions Separation.

Precise ions sieving at angstrom-scale is gaining tremendous attention thanks to its significant impact at the water-energy nexus. Herein, a novel polycation-modulated interfacial polymerization (IP) strategy is developed to prepare a heterogeneously charged covalent organic frameworks (COFs) membrane. Cationic poly(diallyldimethylammonium chloride) (PDDA) regulates the growth and assembly of anionic COFs nanosheets, which thus provides a negative, smooth top surface and positive, rough bottom surface, indicating the presence of heterogeneously charged angstrom-scale channels through the membrane.

ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.

This study aimed to investigate the role of ITFG2, a protein highly expressed in cardiac tissues, in myocardial ischemic injury and its potential interactions with NEDD4-2. An in vivo myocardial infarction (MI) model was induced in mice via left anterior descending artery ligation, and ITFG2 expression was modulated using adeno-associated virus AAV9 vectors. Echocardiography was used to assess cardiac function, and primary mouse cardiomyocytes were cultured and subjected to hypoxia.

Slippery hydrogel surface on PTFE hollow fiber membranes for sustainable emulsion separation.

Establishing an efficient and sustainable membrane module is of great significance for practical oil/water emulsion separation. Superwetting membranes have been extensively studied but cannot meet long lasting separation owing to inevitable membrane fouling. Herein, we constructed a hydrogel-mediated slippery surface on polytetrafluoroethylene (PTFE) hollow fibers and then designed a flexible and swing hollow fiber membrane module inspired by fish gill respiration, which achieved sustainable emulsion separation.

Exploring the therapeutic potential of Xiangsha Liujunzi Wan in Crohn's disease: from network pharmacology approach to experimental validation.

Ethnopharmacological Relevance: Xiangsha Liujunzi Wan (LJZW) is a traditional Chinese medicine (TCM) formula containing a variety of traditional Chinese herb components. Its principal components are often used in the treatment of gastrointestinal diseases and contribute to the treatment of Crohn's disease (CD).

Aim Of The Study: To explore the therapeutic potential of LJZW in CD through network pharmacology, bioinformatics, molecular docking, and experimental verification.

Upcycling the Spent Graphite Anode Into the Prelithiation Catalyst: A Separator Strategy Toward Anode-Free Cell Prototyping.

The substantial manufacturing of lithium-ion batteries (LIBs) requires sustainable, circular, and decarbonized recycling strategies. While efforts are concentrated on extracting valuable metals from cathodes using intricate chemical process, the direct, efficient cathode regeneration remains a technological challenge. More urgently, the battery supply chain also requires the value-added exploitation of retired anodes.

Regulating the Electrochemical Nitrate Reduction Performance with Controllable Distribution of Unconventional Phase Copper on Alloy Nanostructures.

Electrochemical nitrate reduction reaction (NORR) is emerging as a promising strategy for nitrate removal and ammonia (NH) production using renewable electricity. Although great progresses have been achieved, the crystal phase effect of electrocatalysts on NORR remains rarely explored. Here, the epitaxial growth of unconventional 2H Cu on hexagonal close-packed (hcp) IrNi template, resulting in the formation of three IrNiCu@Cu nanostructures, is reported.

Understanding the molecular pathway of triclosan-induced ADHD-like behaviour: Involvement of the hnRNPA1-PKM2-STAT3 feedback loop.

Triclosan (TCS) is an environmental pollutant. In recent years, there has been increasing level of concern regarding the potential toxicity of TCS in animals and humans, especially its effects on the nervous system. However, whether TCS induces ADHD-like behaviour and the mechanism by which it affects neural function are unclear.

Divergent Response of Two Bark Beetle-Fungal Symbiotic Systems to Host Monoterpenes Reflects Niche Partitioning Strategies.

The successful establishment of bark beetle-fungus symbionts on plants is required to overcome host defenses. However, little is known about how different bark beetle-fungus symbionts adapt to different niches on the same host plant. Here, we investigated the niche partitioning mechanism of two co-occurring bark beetle-fungus symbiotic systems, Ips nitidus-Ophiostoma bicolor and Dendroctonus micans-Endoconidiophora laricicola, on Qinghai spruce (Picea crassifolia) tree.

Disrupting the olfactory response in Monochamus saltuarius: Two potential target genes for controlling the vector insect of pine wilt disease.

Worldwide, pine forests have been threatened by a devastating pine wood disease caused by Bursaphelenchus xylophilus, with Monochamus saltuarius being a newly recorded vector of the disease in Northeast China. The olfactory system plays important roles in both feeding and oviposition during the adult stage of M. saltuarius, and olfactory gene function research is essential for gaining an understanding of the olfactory mechanisms of this pest.

Catalytic elevation effect of methylglyoxal on invertase and characterization of MGO modification products.

Reactive carbonyl species can modify digestive enzymes upon intake due to their electrophilic nature. This study evaluated the effects of methylglyoxal (MGO), glyoxal, acrolein, and formaldehyde on invertase, an enzyme presents in digestive tract. Unexpectedly, MGO enhanced, rather than inhibited, invertase activity.

Induction of antiherbivore defense responses in poplars using a methyl jasmonate and mesoporous silica nanoparticle complex.

Background: Poplar in China has long been plagued by the fall webworm Hyphantria cunea. Enhancing plant immunity using chemical elicitors is an environmentally friendly approach to pest control. The phytohormone methyl jasmonate (MeJA) can stimulate the chemical defenses of poplars against herbivores but has been shown to have limited efficacy in practice.

ITFG2, an immune-modulatory protein, targets ATP 5b to maintain mitochondrial function in myocardial infarction.

ITFG2, as an immune-modulatory intracellular protein that modulate the fate of B cells and negatively regulates mTORC1 signaling. ITFG2 is highly expressed in the heart, but its pathophysiological function in heart disease is unclear. In this study, we found that in MI mice, overexpression of ITFG2 via an AAV9 vector significantly reduced the infarct size and ameliorated cardiac function.

Metal Doped Unconventional Phase IrNi Nanobranches: Tunable Electrochemical Nitrate Reduction Performance and Pollutants Upcycling.

Electrochemical nitrate reduction (NORR) provides a new option to abate nitrate contamination with a low carbon footprint. Restricted by competitive hydrogen evolution, achieving satisfied nitrate reduction performance in neutral media is still a challenge, especially for the regulation of this multielectron multiproton reaction. Herein, facile element doping is adopted to tune the catalytic behavior of IrNi alloy nanobranches with an unconventional hexagonal close-packed () phase toward NORR.

Atomic Design of Copper Active Sites in Pristine Metal-Organic Coordination Compounds for Electrocatalytic Carbon Dioxide Reduction.

Electrocatalytic carbon dioxide reduction reaction (CORR) has emerged as a promising and sustainable approach to cut carbon emissions by converting greenhouse gas CO to value-added chemicals and fuels. Metal-organic coordination compounds, especially the copper (Cu)-based coordination compounds, which feature well-defined crystalline structures and designable metal active sites, have attracted much research attention in electrocatalytic CORR. Herein, the recent advances of electrochemical CORR on pristine Cu-based coordination compounds with different types of Cu active sites are reviewed.

Structure-Foldable and Performance-Tailorable PI Paper-Based Triboelectric Nanogenerators Processed and Controlled by Laser-Induced Graphene.

Laser-induced graphene (LIG) technology has provided a new manufacturing strategy for the rapid and scalable assembling of triboelectric nanogenerators (TENG). However, current LIG-based TENG commonly rely on polymer films, e.g.