Publications by authors named "Fu Kiu Ao"
Background: Asian carps, a popular freshwater fish globally, are valued for their flavor and serve as a crucial protein source, especially for infants. However, grass carp parvalbumin is highly allergenic, surpassing the allergenicity of fish like salmon and cod. The allergenic potential of parvalbumin in other Asian carps remains unknown, underscoring the need for allergen identification to improve the precision of fish allergy diagnosis and treatment.
View Article and Find Full Text PDFArticle Synopsis
- Astigmatic mites are significant allergens that can cause allergic diseases, with major allergens identified as Der p 1 and Der f 1 in common house dust mites, leading to immune responses such as asthma and rhinitis.
- A comparative genomic analysis was conducted on cysteine proteases from six mite species to explore their evolutionary relationships, revealing tandem duplication as a key evolution feature and identifying potential new allergens.
- The study highlighted a specific cysteine protease, DP_007902.01, for its strong allergenic potential, while also noting gene decay in the parasitic mite Sarcoptes scabiei, enhancing our understanding of mite allergies.
Background: Numerous studies have suggested associations between depression and cardiometabolic (CM) diseases. However, little is known about the mechanism underlying this comorbidity, and whether the relationship differs by depression subtypes.
Methods: Using polygenic risk scores (PRS) and linkage disequilibrium (LD) score regression, we investigated the genetic overlap of various depression-related phenotypes with a comprehensive panel of 20 CM traits.
Background: Cardiovascular diseases represent a major health issue in patients with schizophrenia (SCZ) and bipolar disorder (BD), but the exact nature of cardiometabolic (CM) abnormalities involved and the underlying mechanisms remain unclear. Psychiatric medications are known risk factors, but it is unclear whether there is a connection between the disorders (SCZ/BD) themselves and CM abnormalities.
Methods: Using polygenic risk scores and linkage disequilibrium score regression, we investigated the shared genetic bases of SCZ and BD with 28 CM traits.