Recent advances in intermolecular 1,2-difunctionalization of alkenes involving trifluoromethylthiolation.

Trifluoromethylthiolative difunctionalization of alkenes, a cheap and abundant feedstock, which installs a trifluoromethylthiol (SCF) group and another unique functional group across the carbon-carbon double bonds, provides an ideal strategy for the preparation of β-functionalized alkyl trifluoromethyl sulfides and has become a hot topic recently. This review aims to summarize the major progress in this exciting research area, with particular emphasis on the mechanistic aspects of the reaction pathways.

Quantification of iodiconazole by LC-MS/MS, a new topical transdermal cream, in dermatophytosis patients' plasma.

Background: A rapid and sensitive LC-MS/MS method was established to measure iodiconazole (ADKZ) in dermatophytosis patients treated topically with 2% ADKZ cream.

Methodology: ADKZ was extracted by liquid-liquid extraction (LLE) and separated by an Agilent Zorbax SB-C18 column (2.1 × 150 mm, 3.

[Effects of pressure therapy on the proliferation and apoptosis of cells in hypertrophic scar of burn patients].

Objective: To explore the effects of pressure therapy on proliferation and apoptosis of cells in hypertrophic scar (HS) of burn patients.

Methods: Twenty patients who were hospitalized from September 2010 to September 2012 and started to wear pressure garment tailored by rehabilitation therapists over 20 hours a day beginning from two weeks after healing of burn wounds with the depth from deep partial-thickness to full-thickness (early stage of formation of HS) were set as pressure treatment group (PT). Another group of patients who were hospitalized in the same period with HS formed 3, 6, 12, 24 months (with 5 patients at each time point) after deep partial-thickness to full-thickness burns without receiving any treatment were set as control group.

[Investigation and analysis of the cognition degree of parents of 150 pediatric burn patients on scar rehabilitation].

Objective: To analyze the cognition degree of parents of pediatric burn patients on hyperplasia of scar and its prevention and rehabilitation, so as to provide a guidance for preventing deformity and dysfunction caused by scar hyperplasia.

Methods: Questionnaire survey was carried out among parents of 150 pediatric burn patients hospitalized from October 2010 to November 2011 to analyze the cognition degree of patients on the formation of scar after burns, the demand degree for scar treatment between parents of different genders of patients and among parents of patients with burn injury occurred in different body sites, the relationship between the literacy level of parents and their degree of willingness of undergoing scar treatment, and the degree of comprehension and acceptance on the part of parents regarding the methods of prevention and treatment of scar. Data were processed with chi-square test or Fisher's exact test.

[Experimental and clinical study on treatment of hypertrophic scars with (90)Sr radiation].

Objective: To analyze the potential mechanism of preventive and therapeutic effects of (90)Sr on hypertrophic scar, and to observe its clinical effect.

Methods: Fibroblasts isolated from human hypertrophic scar were cultured in vitro and radiated by (90)Sr with the dose varying from 0 Gy (control group) to 5 Gy (LD group), 10 Gy (MD group), and 15 Gy (HD group). The cell cycle and apoptosis rate were determined by flow cytometry at post radiation hour (PRH) 24, 48, and 72.

[Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation].

Objective: To study the effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation.

Methods: The hydrogen-rich saline was prepared (hydrogen-saturated normal saline with hydrogen concentration of 0.6 mmol/L).

[Preliminary study on the reliability and validity of Chinese version of the Abbreviated Burn Specific Health Scale].

Objective: To assess the reliability and validity of Chinese version of the Abbreviated Burn Specific Health Scale (BSHS-A).

Methods: BSHS-A was translated into Chinese and revised. Eighty-two former burn patients discharged from the Second Affiliated Hospital of Kunming Medical College, and now in rehabilitation stage, were surveyed with the Chinese version of BSHS-A according to the simple random sampling.

Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats.

Ischemia-reperfusion (I/R) injury of the kidney is a complex pathophysiological process and a major cause of acute renal failure. It has been shown that I/R injury is related to inflammatory responses and activation of apoptotic pathways. Inhibition of certain elements of inflammatory responses and apoptotic pathway seemed to ameliorate renal I/R injury.

[Study on the mechanism of protective effect of oral L-arginine on intestine after scald injury in rats].

Objective: To explore the mechanism of protective effect of oral L-arginine (L-Arg) on the intestine after scald injury in rats.

Methods: Sixty-six Sprague-Dawley (SD) rats were randomly divided into three groups: i.e.

[Study on heredity laws of keratin membrane and sugar content in semi-leafless vegetable pea and their utilization in pea breeding].

It was studied for the heredity laws of keratin membrane and sugar content in semi-leafless vegetable pea. The results showed that keratin membrane character is controlled by two genes. F1 displays large keratin membranes in all fresh pods; F2 has three phenotypes, i.

[Tendril inheritance in semi-leafless pea and its utilization in breeding].

Using semi-leafless pea and common pea, the authors studied tendril character, its inheritance law and how to use it in pea breeding. The results were as follows: Semi-leafless pea had well developed tendrils; They twined with each other and formed an arbor structure. This ideal structure had greatly increased lodging resistance capability,improved canopy's air and light level, and remarkably increased new varieties yield.