Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach.

Accurate, rapid, and low-cost molecular diagnostics is essential in managing outbreaks of infectious diseases, such as the pandemic of coronavirus disease 2019 (COVID-19). Accordingly, microfluidic paper-based analytical devices (μPADs) have emerged as promising diagnostic tools. Among the extensive efforts to improve the performance and usability of diagnostic tools, biosensing mechanisms based on electrochemical impedance spectroscopy (EIS) have shown great promise because of their label-free operation and high sensitivity.

Serotype Is Associated With High Rate of Colistin Resistance Among Clinical Isolates of .

To investigate the prevalence, probable mechanisms and serotype correlation of colistin resistance in clinical isolates of from patients in China, isolates were collected from fecal and blood samples of patients. In this study, 42.8% (136/318) clinical isolated were resistant to colistin.

Synthesis of SnO nanoparticles for formaldehyde detection with high sensitivity and good selectivity.

During the detection of industrial hazardous gases, like formaldehyde (HCHO), the selectivity is still a challenging issue. Herein, an alternative HCHO chemosensor that based on the tin oxide nanoparticles is proposed, which was obtained through a facile hydrothermal method. Gas sensing performances showed that the optimal working temperature located at only 180 °C, the response value of 79 50 ppm HCHO was much higher than that of 35 at 230 °C.

Reactive Oxygen Species Self-Sufficient Multifunctional Nanoplatform for Synergistic Chemo-Photodynamic Therapy with Red/Near-Infrared Dual-Imaging.

Developing multifunctional nanoplatforms that combine controlled drug release, therapy, and real-time monitoring of intracellular distribution of therapeutic agents can provide a solution for practical precision cancer therapy. Herein, a daylight activatable and red to near-infrared (NIR) dual-imaging guided multifunctional anticancer nanoplatform based on diselenium-conjugated and aggregation-induced emission fluorogen (AIEgen)-cross-linked oligoethylenimine polymer loaded with cisplatin (Pt) and biscyclometalated iridium(III) (Ir(III)) complex (Pt&Ir@P NPs) is reported. Upon short-time daylight irradiation, the nanoplatform generates reactive oxygen species (ROS), which help them to escape from endo/lysosomes via enhanced lysosomal membrane permeability.

Construction of Titanium-Based Metal-Organic Frameworks Based on the Ti/Cu Heteronuclear Cluster.

Presented here are two titanium-based metal-organic frameworks (Ti-MOFs) based on well-defined [TiCu(μ-O)(μ-O)(HSO)(SO)], which can be easily obtained from a cheap Ti source and CuSO and exhibited interesting magnetic properties. Furthermore, this clusters can be isolated in pure phase. Numerous uncoordinated sites of SO and labile ligands on the Ti and Cu centers of this cluster make it a good candidate as a secondary building unit to construct various Ti-MOFs in the future.

Identification of the gut microbiota biomarkers associated with heat cycle and failure to enter oestrus in gilts.

Failed puberty is one of the main reasons for eliminating gilts from production herds. This is often caused by disorders of sex hormones. An increasing number of studies have suggested that the gut microbiota may regulate sex hormones and vice versa.

Distinguishing Patients With Distant Metastatic Differentiated Thyroid Cancer Who Biochemically Benefit From Next Radioiodine Treatment.

Background: Repeated radioiodine (I) treatment (RT) are commonly performed in patients with I-avid distant metastatic differentiated thyroid cancer (DM-DTC), but more precise indications remain indeterminate. This prospective study was conducted to explore predictors for biochemical response (BR) to next RT.

Methods: Totally thyroidectomized patients with I-avid DM-DTC demonstrated by initial post-therapeutic whole body scan (Rx-WBS) were consecutively recruited.

Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance.

Cisplatin (Pt(II)) resistance is an important factor in the high mortality rates of ovarian cancer. Herein, we synthesized multifunctional tumor-targeted poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs-cRGD) for monitoring therapeutic effects by dual-mode imaging and overcoming cisplatin resistance. Uniformly sized NPs-cRGD demonstrated controlled and sustained release of drugs and genes, excellent gene loading and gene protection capacity, good storage stability and no serum-induced aggregation in vitro.

Efficient Treatment of Atherosclerosis by Dexamethasone Acetate and Rapamycin Co-Loaded mPEG-DSPE Calcium Phosphate Nanoparticles.

Atherosclerosis (AS) is one of the leading causes of vascular disease, producing high morbidity and mortality in many countries. Autophagy plays an important role when cells are facing serious circumstances, such as oxidative stress induced by Ox-LDL (oxidized low-density lipoprotein). Recent studies have revealed that DEX (dexamethasone acetate) and RAPA (rapamycin) exhibit efficient AS therapeutic ability by protecting endothelial cells and killing foam cells, respectively.

Imaging fibroblast activation protein in liver cancer: a single-center post hoc retrospective analysis to compare [Ga]Ga-FAPI-04 PET/CT versus MRI and [F]-FDG PET/CT.

Purpose: This study aimed to evaluate the potential utility of [Ga]Ga-FAPI-04 PET/CT for diagnosing primary and metastatic lesions in patients with liver cancer, as well as to compare it with contrast-enhanced CT (CE-CT), liver MRI, and [F]-FDG PET/CT.

Methods: We performed a single-center post hoc retrospective analysis of data obtained from a prospective parent study (NCT04416165). This study included 34 patients diagnosed with or suspected hepatic lesions who underwent concomitant [Ga]Ga-FAPI-04 and [F]-FDG/CT scans.

Stk and Stp1 participate in Streptococcus suis serotype 2 pathogenesis by regulating capsule thickness and translocation of certain virulence factors.

Eukaryotic-like serine/threonine protein kinase (eSTK) and phosphatase (eSTP) play multiple roles in pathogenesis of many Gram-positive bacteria. eSTK (Stk) and eSTP (Stp1) of Streptococcus suis serotype 2 (S. suis 2) have also been reported to be virulence-associated, but their roles and underlying mechanisms in S.

Observer-Based Adaptive Synchronization Control of Unknown Discrete-Time Nonlinear Heterogeneous Systems.

This article is concerned with the optimal synchronization problem for discrete-time nonlinear heterogeneous multiagent systems (MASs) with an active leader. To overcome the difficulty in the derivation of the optimal control protocols for these systems, we develop an observer-based adaptive synchronization control approach, including the designs of a distributed observer and a distributed model reference adaptive controller with no prior knowledge of all agents' dynamics. To begin with, for the purpose of estimating the state of a nonlinear active leader for each follower, an adaptive neural network distributed observer is designed.

Metformin prevents brain injury after cardiopulmonary resuscitation by inhibiting the endoplasmic reticulum stress response and activating AMPK-mediated autophagy.

Background And Aims: The neurological damage caused by cardiac arrest (CA) can seriously affect quality of life. We investigated the effect of metformin pretreatment on brain injury and survival in a rat CA/cardiopulmonary resuscitation (CPR) model.

Methods And Results: After 14 days of pretreatment with metformin, rats underwent 9 minutes of asphyxia CA/CPR.

[Corrigendum] miR‑505 suppresses prostate cancer progression by targeting NRCAM.

Subsequently to the publication of this article, one of the corresponding authors, Dr Wei‑De Zhong, has realized that the information presented in the box for correspondence for him was incorrect. Although Dr Zhong is correctly shown as having three affiliation addresses in the paper, the address affiliation listed first on the paper should have been presented as the address for correspondence, not the second one. Therefore, the authors' affiliation information should have appeared as follows (changes are highlighted in bold): Correspondence to: Dr Wei‑ De Zhong, Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou, Guangdong 510515, P.

Galectin-3 and acute heart failure: genetic polymorphisms, plasma level, myocardial fibrosis and 1-year outcomes.

This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. The single-nucleotide polymorphisms (SNPs) of at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. There was no significant difference in MAEs when categorizing patients by the SNPs at rs4644 and rs4652.

Upper Limb Proprioceptive Acuity Assessment Based on Three-Dimensional Position Measurement Systems.

The aim of the current work was to verify three-dimensional directional effects on the reproduction error precision of the human upper limb position. Thirty male subjects without history of upper limb pathology were recruited from Renmin University of China. A three-dimensional position reproduction task in six directions (up, down, left, right, far, and near) was performed by each subject.

Diazaboryl-naphthyl-ketone: A New Scaffold with Bright Fluorescence, Aggregation-Induced Emission, and Application in the Quantitation of Trace Boronic Acids in Drug Intermediates.

This study describes the synthesis, structure, and photophysical properties of a new luminescent polyaromatic boronic acid scaffold, diazaboryl-naphthyl-ketones (DNKs). These stable compounds display extremely bright fluorescence, aggregation-induced emission, positive solvatochromism, and solid-state fluorescence. DFT calculations and X-ray crystallographic study revealed notable electronic and structural differences between these compounds and the parent diaminonaphthalene (DAN) adducts.

Data-Based Optimal Synchronization Control for Discrete-Time Nonlinear Heterogeneous Multiagent Systems.

This article investigates the optimal synchronization problem for unknown discrete-time nonlinear heterogeneous multiagent systems (MASs). It is very intractable to derive the analytical solutions of coupled Bellman's equations, which are necessary to overcome this problem. We propose a data-based optimal synchronization control strategy based on a hierarchical and distributed optimal control framework composed of a model reference adaptive control (MRAC) layer and a distributed control layer.

PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.

Ever reports showed that PCNP is associated with human cancers including neuroblastoma and lung cancer. However, the role and underlying molecular mechanism of PCNP in ovarian cancer have not been plenty elucidated. Herein, we first investigated the expression of PCNP in ovarian cancer tissues and cells, the effects of PCNP in ovarian cancer proliferation, apoptosis, migration and invasion, and determined the molecular mechanism of PCNP in ovarian cancer progression.

Raman reporter-assisted Au nanorod arrays SERS nanoprobe for ultrasensitive detection of mercuric ion (Hg) with superior anti-interference performances.

Ultra sensitive detection of mercuric ion (Hg) with superior anti-interference capability from natural water is of great significance for food safety, environmental protection, and human health. We herein develop Au ordered nanorod arrays (Au NRAs) as surface-enhanced Raman scattering (SERS) substrates to construct SERS-active and signal-reproducible sensing platforms modified with 4-mercaptophenylboronic acid (4-MBA) as multifunctional SERS reporters. The aqueous Hg can be efficiently trapped by 4-MBA through electrophilic substitution reactions and precisely appraise its concentration based on the collective spectral changes of reporters including peak disappearance, emergence, and Raman shift.

Single-pixel sensing with optimal binarized modulation.

Conventional high-level sensing techniques require high-fidelity images as input to extract target features. The images are produced by either complex imaging hardware or high-complexity reconstruction algorithms. In this Letter, we propose single-pixel sensing (SPS) that performs high-level sensing directly from a small amount of coupled single-pixel measurements, without the conventional image acquisition and reconstruction process.

Facile Design and Hydrothermal Synthesis of InO Nanocube Polycrystals with Superior Triethylamine Sensing Properties.

Triethylamine (TEA), a typical kind of volatile organic compound, is widely used as an industrial solvent, which is a threat to environment and human health. In this paper, a novel InO nanocube gas sensing material with high sensing performances was synthesized through a simple one-pot hydrothermal method. The gas sensing test results are satisfactory such that the single phase of InO nanocubes even exhibits a quite higher response of 12-10 ppm of TEA at a lower temperature (180 °C) than many conventional InO-based complexes and maintains high consistency in morphology and stability after the consecutive tests of 2 months.

The cyclopeptide -amatoxin induced hepatic injury via the mitochondrial apoptotic pathway associated with oxidative stress.

In order to explore the role of apoptosis in alpha-amatoxin (α-AMA) induced liver injury and probable upstream activation signals, we established animal and cellular models, respectively, for this pathophysiological condition. To this end, we evaluated the survival rate and serum biochemical parameters in BALB/c mice exposed to α-AMA at different time periods, along with the levels of oxidative and antioxidant enzymes in the liver tissue of these mice and proteins involved in apoptosis-related pathways. Our results reveal that α-AMA-induced apoptosis occurs primarily through the mitochondrial apoptotic pathway and is associated with oxidative damage.

Broadband perovskite quantum dot spectrometer beyond human visual resolution.

The quantum dot spectrometer, fabricated by integrating different quantum dots with an image sensor to reconstruct the target spectrum from spectral-coupled measurements, is an emerging and promising hyperspectrometry technology with high resolution and a compact size. The spectral resolution and spectral range of quantum dot spectrometers have been limited by the spectral variety of the available quantum dots and the robustness of algorithmic reconstruction. Moreover, the spectrometer integration of quantum dots also suffers from inherent photoluminescence emission and poor batch-to-batch repeatability.

Unexplained Hyperthyroglobulinemia in Differentiated Thyroid Cancer Patients as an Indication for Radioiodine Adjuvant Therapy: A Prospective Multicenter Study.

The management for totally thyroidectomized differentiated thyroid cancer (TT-DTC) patients with unexplained hyperthyroglobulinemia remains indeterminate because of evidence scarcity. This multicenter study aimed at prospectively evaluating the response to radioiodine (I) adjuvant therapy (RAT) and its potential role in risk stratification and causal clarification. TT-DTC patients with stimulated serum thyroglobulin levels greater than 10 ng/mL but no structurally evident disease were consecutively enrolled in 5 tertiary-care institutions.