Local Environment-Modulated f-f Transition in Unit-Cell-Sized Lanthanide Ultrathin Nanostructures.

The regulation of the f-f transition is the basis of utilizing the abundant optical properties of lanthanide (Ln), of which the key is to modulate the local environment of Ln ions. Here, we constructed Eu(III)-based unit-cell-sized ultrathin nanowires (UCNWs) with red luminescence and polymer-like behavior, which appears as an ideal carrier for regulating f-f transition. The f-f transition of Eu(III) in UCNWs could be precisely regulated through various ligands.

Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways.

Atopic dermatitis (AD) is a common inflammatory dermatitis of the skin and poses therapeutic challenges due to the adverse reactions and high costs associated with available treatments. In Eastern Asian countries, a plethora of herbal remedies is extensively employed for the alleviation of AD. Many of these botanicals are renowned for their formidable anti-inflammatory properties, contributing to AD management.

Buried interface engineering towards stable zinc anodes for high-performance aqueous zinc-ion batteries.

The dendrite and corrosion issues still remain for zinc anodes. Interface modification of anodes has been widely used for stabilizing zinc anodes. However, it is still quite challenging for such modification to simultaneously suppress zinc dendrites and corrosion issues.

The potential role of vesicle transport-related small GTPases rabs in abiotic stress responses.

Rab GTPases are a class of small GTP-binding proteins, play crucial roles in the membrane transport machinery with in eukaryotic cells. They dynamically regulate the precise targeting and tethering of transport vesicles to specific compartments by transitioning between active and inactive states. In plants, Rab GTPases are classified into eight distinct subfamilies: Rab1/D, Rab2/B, Rab5/F, Rab6/H, Rab7/G, Rab8/E, Rab11/A, and Rab18/C.

Qualitative Transcriptional Signature for Predicting the Pathological Response of Colorectal Cancer to FOLFIRI Therapy.

FOLFIRI (5-FU, leucovorin, irinotecan) is the first-line chemotherapy for metastatic colorectal cancer (mCRC), but response rates are under 50%. This study aimed to develop a predictive signature for FOLFIRI response in mCRC patients. Firstly, Spearman's rank correlation and Wilcoxon rank-sum test were used to select chemotherapy response genes and gene pairs, respectively.

Personalized federated learning for abdominal multi-organ segmentation based on frequency domain aggregation.

Purpose: The training of deep learning (DL) models in medical images requires large amounts of sensitive patient data. However, acquiring adequately labeled datasets is challenging because of the heavy workload of manual annotations and the stringent privacy protocols.

Methods: Federated learning (FL) provides an alternative approach in which a coalition of clients collaboratively trains models without exchanging the underlying datasets.

Alteration of Immune Function and Gut Microbiome Composition in Carassius auratus Challenged With Rahnella aquatilis.

Rahnella aquatilis as an emerging pathogen can cause bacterial enteritis in cyprinid fish such as crucian carp Carassius auratus. Currently, the characterisation of immune function and gut microbiome composition in C. auratus orally challenged by R.

Boosting Enzyme-like Activities Atomization of Cerium for Tumor Microenvironment-Responsive Cascade Therapy.

Nanozyme catalytic therapeutic efficacy is limited by the finite enzyme activity and specificity. In this work, nitrogen-doped carbon loaded with a cerium single-atom nanozyme (Ce SAs@NC) is synthesized, exhibiting tumor specificity and excellent multiple enzyme-like activities. Compared with nitrogen-doped carbon loaded with CeO nanoparticles, Ce SAs@NC shows excellent peroxidase-like and catalase-like activity.

Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study.

Background: Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety disorder (AXD) and constipation. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal associations between them.

Structural and functional optimization of glycoprotein-enzymes for targeted biocatalysis in oral squamous cell carcinoma.

The efficacy of optimized glycoproteinenzymes as a novel therapeutic approach for oral squamous cell carcinoma (OSCC) was tested in this study. The stability and viability of SCC-25 and HN4 operating-system cell lines were characterized. Both lines were confirmed to have a spindle-like morphology for SCC-25, while HN4 cells exhibited cobblestone-like clusters.

Foodborne pathogen detection using surface acoustic wave biosensors: a review.

This paper summarizes several attractive surface acoustic wave (SAW) biosensors, including Love-wave sensors, dual-channel SAW sensors, langasite SAW sensors, and SAW syringe filters. SAW sensors with different piezoelectric materials and high-frequency SAW sensors used for identifying the food pathogenic bacteria () are discussed together with the examples of methods based on such sensing technology that have been effectively utilized in diagnostics and epidemiological research. This review also emphasizes some of the limitations of using these biosensors, which have prompted the increased need for more rapid, sensitive, selective, portable, power-efficient, and low-cost methods for detecting these pathogens.

Accuracy of self-reported height, weight, and waist circumference in poor, rural areas of China.

Objectives: There are differing opinions and findings about the accuracy of self-reported data. This study sought to assess the accuracy of self-reported height, weight, and waist circumference (WC) data among adult residents in poor, rural areas of China.

Methods: Multi-stage stratified cluster random sampling was used to sample rural adult residents in Jinzhai County.

7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.

Objective: This research aimed to delineate the pharmacological mechanisms of 7-Hydroxycoumarin (7-HC) on ulcerative colitis (UC) employing network pharmacology and experimental validation.

Methods: To investigate the therapeutic effects of 7-HC on UC, a UC mouse model was established through the unrestricted intake of 3.0% dextran sulfate sodium (DSS) in their drinking water.

68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer.

BACKGROUNDConsidering that trophoblast cell-surface antigen 2 (Trop2) is overexpressed in a wide range of human epithelial cancers, it presents an attractive target for diagnosis and treatment of multiple types of cancer. Herein, we have developed a Trop2-specific radiotracer, 68Ga-MY6349, and present a prospective, investigator-initiated trial to explore the clinical value of 68Ga-MY6349 PET/CT.METHODSIn this translational study, 90 patients with 15 types of cancer who underwent 68Ga-MY6349 PET/CT were enrolled prospectively.

Comprehensive evaluation of freezing tolerance in prickly ash and its correlation with ecological and geographical origin factors.

Low temperatures are a key factor affecting the growth, development, and geographical distribution of prickly ash. This study investigated the impact of ecological and geographical factors on the freezing tolerance of prickly ash germplasm. Thirty-seven germplasm samples from 18 different origins were collected, and their freezing tolerance was comprehensively evaluated.

Evaluation of cosmetic efficacy of lychee seed fermentation liquid.

Background: Lychee seeds were fermented by three kinds of bacteria (Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma lucidum mycelium), and two effective strains were selected by two indexes of activity content and antioxidant, so as to further verify whether lychee seeds have waste multiplication effect and can protect cells damaged by oxidation from anti-inflammatory, anti-aging and safety.

Results: The contents of polyphenols, flavonoids and proteins in the solution fermented by Ganoderma lucidum mycelium did not increase, thus affecting the antioxidant capacity of the solution was far less than that of the water extract. The active content of the other two fermentation solutions was higher than that of the water extract, and the ability of scavenging free radicals of the two solutions increased with the increase of the volume fraction.

Comparative Study of Different Inflammation Definition Methods of GLIM in the Diagnosis of Malnutrition in Patients with Acute Pancreatitis.

Purpose: This study aims to investigate the influence of the Global Leadership Initiative on Malnutrition (GLIM) on diagnosing malnutrition in acute pancreatitis (AP) based on various inflammatory criteria.

Patients And Methods: A total of 258 AP patients admitted to a large medical center between June 2019 and January 2022 were retrospectively analyzed. All patients underwent evaluation using the original GLIM and GLIM criteria based on C-reactive protein (CRP), albumin, neutrophil/lymphocyte ratio, and CRP/albumin ratio (CAR).

Synergistic Cationic Shielding and Anionic Chemistry of Potassium Hydrogen Phthalate for Ultrastable Zn─I Full Batteries.

Electrolyte additives are investigated to resolve dendrite growth, hydrogen evolution reaction, and corrosion of Zn metal. In particular, the electrostatic shielding cationic strategy is considered an effective method to regulate deposition morphology. However, it is very difficult for such a simple cationic modification to avoid competitive hydrogen evolution reactions, corrosion, and interfacial pH fluctuations.

Correction: Jiang et al. Characterization of Functional Microorganisms in Representative Traditional Fermented Dongcai from Different Regions of China. 2023, , 1753.

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