Publications by authors named "Frumholtz L"
Background: The outbreak of chilblain-like lesions (CLL) during the COVID-19 pandemic has been reported extensively, potentially related to SARS-CoV-2 infection, yet its underlying pathophysiology is unclear.
Objectives: To study skin and blood endothelial and immune system activation in CLL in comparison with healthy controls and seasonal chilblains (SC), defined as cold-induced sporadic chilblains occurring during 2015 and 2019 with exclusion of chilblain lupus.
Methods: This observational study was conducted during 9-16 April 2020 at Saint-Louis Hospital, Paris, France.
Article Synopsis
- Cutaneous polyarteritis nodosa is a medium-sized vessel vasculitis with limited data on treatment effectiveness and safety.
- A study analyzed treatment responses in 68 patients and found that glucocorticoids combined with azathioprine had the highest success rate and longest duration of effectiveness.
- Overall treatment-related adverse events were reported in 18% of cases, indicating that while some treatments are effective, they can also lead to complications.
Article Synopsis
- Gastrointestinal (GI) involvement in systemic necrotizing vasculitis is linked to a poor prognosis, and its impact can differ based on clinical presentation and specific vasculitis subtypes.
- A study assessed 213 patients with various types of vasculitis who had GI complications, finding that 39% experienced severe outcomes like ICU admission, surgery, or death within six months.
- Key risk factors for these poor outcomes included specific vasculitis subtype (especially polyarteritis nodosa), certain symptoms (like abdominal guarding and melena), and lab results (like high leukocyte counts and low hemoglobin levels), leading to the development of an effective risk prediction model.
Teledermatology for COVID-19 cutaneous lesions: substitute or supplement?
J Eur Acad Dermatol Venereol
October 2020
Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations.
Clin Rev Allergy Immunol
October 2021
Article Synopsis
- Cutaneous vasculitis is an inflammatory condition affecting the blood vessels in the skin, making the skin a key area for diagnosis and examination through accessible biopsies.
- It can represent various forms, ranging from a skin-limited condition to an indication of systemic vasculitis, with lesions that vary in appearance based on the size and location of the affected vessels.
- Understanding skin vascular anatomy and the types of lesions and inflammatory infiltrates is essential for accurate diagnosis, alongside recommended additional tests for skin lesions indicative of vasculitis.
Article Synopsis
- The text presents a case of a patient with systemic lupus erythematosus (SLE) who developed skin lesions similar to those seen in chronic HTLV-1 infections.
- It implies that certain patients with lupus might experience immune system issues that are comparable to those caused by HTLV-1.
- This finding highlights a potential link between HTLV-1 and autoimmune conditions like lupus, suggesting a need for further research.
Article Synopsis
- MAIT cells, which play a role in antibacterial immunity, are found to be significantly decreased in patients with active Dermatomyositis (DM) and Systemic Lupus Erythematosus (SLE), compared to healthy controls and other skin diseases.
- A study compared the frequencies and characteristics of MAIT cells in DM patients (both active and inactive) alongside other conditions, revealing a dramatic drop in MAIT cell levels in active DM (0.25%) compared to healthy individuals (2.32%).
- The MAIT cells from active DM patients also showed an abnormal phenotype, with increased markers of activation that indicate a possible link to their low frequency and increased risk of cell death
Seborrheic area involvement in patients with systemic lupus erythematosus.
J Eur Acad Dermatol Venereol
August 2019
Background: While some information on psoriasis impact on pregnancy is available, very little is known on the preoccupations of women afflicted by the disease or on the dermatologists' (D) positioning as to psoriasis and pregnancy. The 'Objectifs Peau' project demonstrated a 4.7% prevalence of psoriasis in women aged 18-45 years in France.
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