Closeness discrepancies in romantic relationships: implications for relational well-being, stability, and mental health.

Experiences of closeness in romantic relationships are associated with heightened levels of relational well-being and mental health. However, individuals differ in the degree of closeness they desire in their relationships. This study used the construct of inclusion of other in self (IOS) to analyze discrepancies between individuals' actual and ideal levels of closeness in their relationships and the implications of these discrepancies for relational well-being and mental health.

Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function.

Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug (APD) treatment. Most APDs are potent antagonists or partial agonists of dopamine (DA) D₂ receptors; atypical APDs also have multiple serotonergic activities.

Unilateral ankle immobilization alters the kinematics and kinetics of lifting.

Background: Theoretical and empirical data support the notion that distal lower extremity joint dysfunction could influence the low-back injury potential of workers, but the impact of unilateral ankle immobilization on low-back loading during lifting has yet to be examined.

Objective: To examine the influence of unilateral ankle immobilization on the kinematics and kinetics of lifting.

Methods: With and without their right ankle immobilized, 10 men performed laboratory-simulated occupational lifting tasks.

The oxidation state of the mantle and the extraction of carbon from Earth's interior.

Determining the oxygen fugacity of Earth's silicate mantle is of prime importance because it affects the speciation and mobility of volatile elements in the interior and has controlled the character of degassing species from the Earth since the planet's formation. Oxygen fugacities recorded by garnet-bearing peridotite xenoliths from Archaean lithosphere are of particular interest, because they provide constraints on the nature of volatile-bearing metasomatic fluids and melts active in the oldest mantle samples, including those in which diamonds are found. Here we report the results of experiments to test garnet oxythermobarometry equilibria under high-pressure conditions relevant to the deepest mantle xenoliths.

Movement quality and links to measures of fitness in firefighters.

Background/objective: Given the possible links between movement, fitness and injury, the goal of this study was to evaluate strength, endurance, and hip range of motion (ROM) (i.e. fitness); movement quality; and age in a population of firefighters.

The influence of resistance bands on frontal plane knee mechanics during body-weight squat and vertical jump movements.

The purpose of this study was to examine the impact of wearing a resistance band around the distal thigh on frontal plane knee mechanics during bodyweight squat and jumping exercises. Three closed-kinetic-chain exercises were examined, including: (1) bodyweight squat, (2) countermovement jump, and (3) squat jump. For each exercise, three experimental conditions were tested: (1) control condition with no band; (2) light-tension band applied around the distal thighs; and (3) medium-tension band applied around the distal thighs.

Experience and the developing prefrontal cortex.

The prefrontal cortex (PFC) receives input from all other cortical regions and functions to plan and direct motor, cognitive, affective, and social behavior across time. It has a prolonged development, which allows the acquisition of complex cognitive abilities through experience but makes it susceptible to factors that can lead to abnormal functioning, which is often manifested in neuropsychiatric disorders. When the PFC is exposed to different environmental events during development, such as sensory stimuli, stress, drugs, hormones, and social experiences (including both parental and peer interactions), the developing PFC may develop in different ways.

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

Objective: To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations.

Design: Retrospective cohort study (GENE-RAD-RISK).

Setting: Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands,

Participants: 1993 female carriers of BRCA1/2 mutations recruited in 2006-09.

Molecular dynamics studies on the adaptability of an ionic liquid in the extraction of solid nanoparticles.

Recently, a number of publications have suggested that ionic liquids (ILs) can absorb solid particles. This development may have implications in fields like oil sand processing, oil spill beach cleanup, and water treatment. In this Article, we provide a computational investigation of this phenomenon via molecular dynamics simulations.

Understanding droplet bridging in ionic liquid-based Pickering emulsions.

We have studied the unique bridging behavior of solid-stabilized oil-in-ionic liquid (IL) and water-in-ionic liquid emulsions with respect to particle concentration, particle size, and droplet phase using a confocal laser scanning microscope. The emulsions exhibited three morphology regimes: (1) single, sparingly covered droplets, (2) bridged clusters of droplets, and (3) fully covered droplets. The degree of bridging was directly proportional to the total potential bridging area which can be determined from the particle size and concentration.

Morning report blog: a web-based tool to enhance case-based learning.

Background: Morning report is an interactive case-based teaching session common to internal medicine training programs across North America.

Description: We report here on a morning report web log ("blog"), created and updated after morning report sessions by the Chief Medical Resident with pertinent clinical topics, links to journal articles, and medical images. Trainees on their internal medicine rotation were e-mailed a web link with each posting.

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC).

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.

Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.

Methods: IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.

Background: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.

Methods: To evaluate the potential role of genetic variants within PHB and MTHFR in breast and ovarian cancer risk, 4102 BRCA1 and 2093 BRCA2 mutation carriers, and 6211 BRCA1 and 2902 BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA) were genotyped for the PHB 1630 C>T (rs6917) polymorphism and the MTHFR 677 C>T (rs1801133) polymorphism, respectively.

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers.

Introduction: Cis-acting regulatory single nucleotide polymorphisms (SNPs) at specific loci may modulate penetrance of germline mutations at the same loci by introducing different levels of expression of the wild-type allele. We have previously reported that BRCA2 shows differential allelic expression and we hypothesize that the known variable penetrance of BRCA2 mutations might be associated with this mechanism.

Methods: We combined haplotype analysis and differential allelic expression of BRCA2 in breast tissue to identify expression haplotypes and candidate cis-regulatory variants.

Is there a low-back cost to hip-centric exercise? Quantifying the lumbar spine joint compression and shear forces during movements used to overload the hips.

The aim of this study was to quantify joint compression and shear forces at L4/L5 during exercises used to overload the hips. Nine men performed 36 "walking" trials using two modalities: (1) sled towing and (2) exercise bands placed around the ankles. Participants completed forward, backward, and lateral trials with bent and straight legs at three separate loads.

Formation of a disordered solid via a shock-induced transition in a dense particle suspension.

Shock wave propagation in multiphase media is typically dominated by the relative compressibility of the two components of the mixture. The difference in the compressibility of the components results in a shock-induced variation in the effective volume fraction of the suspension tending toward the random-close-packing limit for the system, and a disordered solid can take form within the suspension. The present study uses a Hugoniot-based model to demonstrate this variation in the volume fraction of the solid phase as well as a simple hard-sphere model to investigate the formation of disordered structures within uniaxially compressed model suspensions.

Molecular dynamics simulations of charged nanoparticle self-assembly at ionic liquid-water and ionic liquid-oil interfaces.

Nanoparticle self-assembly at liquid-liquid interfaces can be significantly affected by the individual nanoparticle charges. This is particularly true at ionic liquid (IL) based interfaces, where Coulombic forces play a major role. Employing 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF(6)]) as a model IL, we have studied the self-assembly of hydrophobic nanoparticles with different surface charges at the IL/water and IL/oil (hexane) interfaces using molecular dynamics simulations.

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.

Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively.

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers.

Introduction: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2).

High-pressure synthetic (Na(0.97)Mg(0.03))(Mg(0.43)Fe(0.17)Si(0.40))Si(2)O(6), with six-coordinated silicon, isostructural with P2/n omphacite.

The title compound, (sodium magnesium) [magnesium iron(III) silicon] disilicate, (Na(0.97)Mg(0.03))(Mg(0.

The relationship between general measures of fitness, passive range of motion and whole-body movement quality.

Unlabelled: The goal of this study was to establish relationships between fitness (torso endurance, grip strength and pull-ups), hip range of motion (ROM) (extension, flexion, internal and external rotation) and movement quality in an occupational group with physical work demands. Fifty-three men from the emergency task force of a major city police force were investigated. The movement screen comprised standing and seated posture, gait, segmental spine motion and 14 tasks designed to challenge whole-body coordination.

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer.

Context: Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.

Objective: To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns.