Publications by authors named "Frolov Evgeny"
Comparison of disease phenotypes and mechanistic insight on causal variants in patients with DADA2.
J Allergy Clin Immunol
September 2023
Article Synopsis
- Deficiency of adenosine deaminase 2 (DADA2) leads to various health issues, like systemic vasculitis and red cell aplasia, but the reasons for these different manifestations are not fully understood.
- Researchers aimed to clarify the disease symptoms in DADA2 and understand how different ADA2 gene variants affect the disease.
- The study found that patients with DADA2 have similar inflammation-related gene expressions, and the analyzed ADA2 variants disrupt protein function through several mechanisms, contributing to the clinical diversity seen in patients.
Microbial communities of Kamchatka Peninsula terrestrial hot springs were studied using molecular, radioisotopic and cultural approaches. Analysis of 16S rRNA gene fragments performed by means of high-throughput sequencing revealed that aerobic autotrophic sulfur-oxidizing bacteria of the genus Sulfurihydrogenibium (phylum Aquificae) dominated in a majority of streamers. Another widely distributed and abundant group was that of anaerobic bacteria of the genus Caldimicrobium (phylum Thermodesulfobacteria).
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