Publications by authors named "Fritz Oberhollenzer"
Article Synopsis
- ! In a study involving 205 STEMI patients, researchers measured PCSK9 levels to assess its role as a biomarker in ischemia-reperfusion injury after primary PCI. * ! PCSK9 levels significantly increased from 24 to 48 hours post-PCI, with higher concentrations at 48 hours correlating to intramyocardial hemorrhage, microvascular obstruction, and larger infarct sizes. * ! Patients with elevated PCSK9 levels over 361 ng/mL at 48 hours had a higher likelihood of experiencing major adverse cardiac events within a median follow-up of 12 months.
Background: The prognostic significance of various microvascular injury (MVI) patterns after ST-segment elevation myocardial infarction (STEMI) is not well known.
Objectives: This study sought to investigate the prognostic implications of different MVI patterns in STEMI patients.
Methods: The authors analyzed 1,109 STEMI patients included in 3 prospective studies.
Article Synopsis
- The study investigates the link between plasma neuropeptide-Y (NPY) levels and heart muscle function in patients who suffered from a ST-elevation myocardial infarction (STEMI) and were treated with a procedure called primary percutaneous coronary intervention (PCI).
- Results show that higher NPY levels are connected to poorer heart function indicators, such as lower left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS), as well as larger infarct sizes (IS) and microvascular obstruction (MVO).
- The findings suggest that elevated NPY levels after a heart attack might be an important marker for evaluating heart damage and recovery prospects, independent of other clinical factors.
Background: Microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) are well-established imaging biomarkers of failed myocardial tissue reperfusion in patients with ST-segment elevation-myocardial infarction treated with percutaneous coronary intervention. MVO and IMH are associated with an increased risk of adverse outcome independent of infarct size, but whether the size of the culprit lesion vessel plays a role in the occurrence and severity of reperfusion injury is currently unknown. This study aimed to evaluate the association between culprit lesion vessel size and the occurrence and severity of reperfusion injury as determined by cardiac magnetic resonance imaging.
View Article and Find Full Text PDFBackground: Dysglycaemia increases the risk of myocardial infarction and subsequent recurrent cardiovascular events. However, the role of dysglycaemia in ischemia/reperfusion injury with development of irreversible myocardial tissue alterations remains poorly understood. In this study we aimed to investigate the association of ongoing dysglycaemia with persistence of infarct core iron and their longitudinal changes over time in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI).
View Article and Find Full Text PDFBackground: Computed tomography (CT) is recommended for guiding transcatheter aortic valve replacement (TAVR). However, a sizable proportion of TAVR candidates have chronic kidney disease, in whom the use of iodinated contrast media is a limitation. Cardiac magnetic resonance imaging (CMR) is a promising alternative, but randomized data comparing the effectiveness of CMR-guided versus CT-guided TAVR are lacking.
View Article and Find Full Text PDFAim: The aim of this study was to investigate predictors of transthoracic echocardiography (TTE)-occult left ventricular (LV) thrombi (LVT) and to propose a clinical model for improved detection of TTE-occult LVT post-ST-elevation myocardial infarction (STEMI). Patients with acute STEMI are at significant risk for developing LVT. However, this complication often (up to 65%) remains undetected by using TTE, referred to as TTE-occult LVT.
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