Publications by authors named "Fritz Goetz"
Article Synopsis
- * Clinical ERP measurements were taken from seven patients and used to create anatomical atrial models, comparing four different approaches to modeling ERP distributions, including both personalized and non-personalized methods.
- * Results show that incorporating personalized ERP increased arrhythmia inducibility compared to uniform distributions; however, the presence of fibrotic areas altered the dynamics, suggesting that personalized ERP modeling could significantly impact clinical outcomes.
Article Synopsis
- Sexual activity and reproduction may help certain types of mole-rats live much longer, potentially doubling their lifespan.
- Researchers studied 636 samples from different tissues to understand what causes these longer lifespans, focusing on changes in stress regulation.
- Some findings about how these long-lived mole-rats age don't match what scientists learned from studying shorter-lived animals, suggesting the rules for aging might be different for different species.
The neuropilin-plexin receptor complex regulates tumor cell migration and proliferation and thus is an interesting therapeutic target. High expression of neuropilin-1 is indeed associated with a bad prognosis in glioma patients. Q-RTPCR and tissue-array analyses showed here that Plexin-A1 is highly expressed in glioblastoma and that the highest level of expression correlates with the worse survival of patients.
View Article and Find Full Text PDFCYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.
Clin Pharmacol Ther
February 2014
Article Synopsis
- The International Tamoxifen Pharmacogenomics Consortium conducted a meta-analysis of 4,973 patients to investigate the link between CYP2D6 status and outcomes in tamoxifen therapy for breast cancer.
- Poor metabolizer status for CYP2D6 was associated with worse invasive disease-free survival when strict criteria were followed, showing a hazard ratio of 1.25.
- However, this association became less significant when different criteria were used, suggesting that more prospective studies are needed to better understand the role of CYP2D6 genotyping in tamoxifen treatment.
Context: The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorphic cytochrome P450 2D6 (CYP2D6) enzyme.
Objective: To determine whether CYP2D6 variation is associated with clinical outcomes in women receiving adjuvant tamoxifen.
Xenopus XlHbox 1 produces two transcripts during early development. One encodes a long open reading frame (ORF) and the other a short ORF sharing the same homeodomain, but differing by an 82 amino acid domain at the amino terminus. The long protein amino terminus is conserved with many other homeodomain proteins, and its absence from the short protein could have functional consequences.
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