The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease.

Clinical outcome and relevance of genetic and epidemiological factors were evaluated in 161 patients with idiopathic Parkinson's disease (PD) with regard to onset symptoms [tremor (T) vs non-tremor (NT)], to clinical classification into tremor-dominant (TD), alkineto-rigid (AR), and equivalent (EQ) subtypes, and to disease onset before the 45th year of age (EO) and after age 69 (LO). Patients were investigated by questionnaire-based personal interview and clinical examination. Allegedly symptomatic first-degree relatives were examined personally or had sufficient medical documentation to allow neurological diagnosis.

[Multifactorial etiology of idiopathic Parkinson disease. A case-control study].

The etiology of Parkinson's disease (PD) is currently thought to be due to an interplay of genetic and environmental factors. We examined (1) familial prevalences of PD and essential tremor (ET) using a control population and personal investigation; (2) comorbidity and possible traits of a altered premorbid lifestyle in PD were also investigated. Sixty-six PD patients with disease onset after 40 and before 70 years of life and 72 age- and sex-matched hospital controls with chronic diseases underwent neurologic examination and a structured interview.

Double-blind comparison of amorolfine and bifonazole in the treatment of dermatomycoses.

A total of 232 patients with mycoses of skin folds, body, or feet were entered into a double-blind, parallel group-study. Therapy with 0.125, 0.

Parkinson's disease in twins.

Among nine monozygotic (MZ) and 12 dizygotic (DZ) twin pairs in which an index case had typical Parkinson's disease (PD) or PD with associated dementia, three MZ and three DZ pairs were concordant. Three of the six affected co-twins were first diagnosed during the study. Occurrence of PD in families of MZ and DZ index cases was more frequent than expected from population rates.

Life-style and dietary factors early and late in Parkinson's disease.

The study investigated features of life-style and dietary habits early and late in life of patients with idiopathic Parkinson's disease (IPD). Seventy-one patients and 103 controls were interviewed personally with a structured questionnaire. Living in villages during primary school time was significantly more frequent among patients, and in the urban environment patients had lived less frequently in larger-sized towns.

[Autologous blood transfusion in breast reduction].

Minimal risk blood transfusion is possible using autologous blood. When excessive blood loss is expected in reduction mammaplasty, autologous blood transfusion is recommended. Only three of eighty-one patients who underwent reduction mammaplasty in our department received homologous blood transfusions.

Trichloroharmanes as potential endogenously formed inducers of Morbus Parkinson: synthesis, analytics, and first in vivo-investigations.

The hypnotic chloral reacts chemically with tryptamine and tryptophan under physiological conditions to give novel trichloro-tetrahydroharmanes ("TTHs"). These are structurally similar to the classical neurotoxin MPTP. Moreover, the TTH-precursor chloral is also a metabolite of the frequently used solvent trichloroethylene (Tri).

[Value of non-plethysmographic methods in determining airway resistance].

To examine whether the complicated method of body plethysmography can be replaced by non-plethysmographic methods, such as oscilloresistometry (Ros), the closing pressure method (Run) or the forced expiration volume method (FEV1), the authors studied the results obtained with 247 hospitalised patients between 18 and 81 years of age suffering from, or free from, airway obstruction. Although satisfactory correlations were obtained by linear and curvilinear regression analysis, considerable differences were seen in individual patients suffering from obstructions to a higher degree. Oscilloresistometry showed at the standard value limit of the airway resistance applicable in body plethysmography (0.

Endogenous Alkaloids in Man - Synthesis, Analytics, in vivo Identification, and Medicinal Importance*,1.

The IN VITRO and IN VIVO condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B (6), chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.

Endogenous alkaloids in man--synthesis, analytics, in vivo identification, and medicinal importance.

The in vitro and in vivo condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B6, chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.

Semen parameters in men with and without proven chronic prostatitis.

In patients with complaints of chronic prostatitis, analysis of prostatic secretions for leukocytes and the use of the four-specimen technique allow a distinct classification of chronic bacterial (CBP), nonbacterial prostatitis (NBP), and prostatodynia (Pd). In this study, 32 men with CBP, 102 men with NBP, 142 men with Pd, and 42 volunteers, classified as mentioned above, underwent a two-fold ejaculate analysis using WHO criteria. Sperm count, progressive motility, range of abnormal spermatozoa, increased numbers of common bacteria, and peroxidase-positive leukocytes were analyzed.

[Initial therapy of acute unilateral epididymitis using ofloxacin. II. Andrological findings].

A total of 70 men suffering from uncomplicated acute unilateral epididymitis were enrolled in a prospective study. They were treated initially with 2 x 200 mg ofloxacin p.o.

[Initial therapy of acute unilateral epididymitis using ofloxacin. I. Clinical and microbiological findings].

In a prospective study, 70 men suffering from uncomplicated acute unilateral epididymitis were treated initially with 2 x 200 mg ofloxacin p.o. per day for 14 days.

[Sonographic diagnosis of gastroesophageal reflux in infancy].

The gastroesophageal reflux is a common problem in the pediatric clinical practice in the 1st year of life. Its diagnosis is mainly based on the x-ray and the measurement of the esophageal pH. Our investigation shows the possibility of the ultrasonographical diagnosis of this disturbance.

[Results of intervertebral disk surgery in advanced age].

Among 2983 patients operated upon for herniated lumbar disks from 1981 through 1985 193 were between 65 and 84 years of age. Many of them had long-standing histories of recurrent sciatica. Most patients presented with unilateral or bilateral radicular pain, motor weakness or paresis and typical sensory changes.

Intramedullary vascular lesions in the high cervical region: transoral and dorsal surgical approach. Two case reports.

Intramedullary vascular malformations in the high cervical region are extremely rare. Two young adult patients with vascular lesions at the level C 2 and 3, and C 2-4 are reported. In one patient selective spinal angiography revealed a combined malformation with a ventral intramedullary arteriovenous angioma and a premedullary aneurysm.

[Status of the captopril test in the diagnosis of hypertension].

The place of captopril (C) testing in the screening for renovascular hypertension is still controversial. Baseline and C-stimulated plasma renin concentrations (PRC) were measured in 113 hypertensives, who where referred for the exclusion of secondary hypertension. In addition intravenous digital subtraction angiography (DSA) and a renal scintigraphy were performed.

Man systems aspects in the design concept of the Columbus Man-Tended Free-Flyer (MTFF).

The Man-Tended Free-Flyer (MTFF) of the European Space Agency's COLUMBUS Program is a free flying pressurized laboratory in which payload processes will be performed in an automatic mode, i.e. without presence of man.

[Illness and threat. Forms of psychosocial coping in multiple sclerosis].

The onset of a chronic illness is synonymous with a massive breach in the stability and routine in the daily life of the patient. These individuals are thus confronted with the task of integrating the illness and its consequences into their lives in a manner that, despite and with the illness, will allow them to live as normal life as possible. Multiple Sclerosis, however, presents specific problems in the sense that it is chronic illness with uncertain prognosis whose course can neither be predicted nor influenced.