Publications by authors named "Friederike Weigel"
Article Synopsis
- Glomerular kidney diseases start slowly, can lead to severe kidney failure, and require early diagnosis for effective treatment.
- The study focused on evaluating protein biomarkers in children to help detect common nephropathies, particularly related to conditions like Alport syndrome.
- Results showed that specific urinary biomarkers, especially collagen type XIII, hyaluronan-binding protein 2, and complement C4-binding protein, may be effective indicators of early kidney injury.
Introduction: Alport syndrome (AS) is a hereditary type IV collagen disease. It starts shortly after birth, without clinical symptoms, and progresses to end-stage kidney disease early in life. The earlier therapy starts, the more effectively end-stage kidney disease can be delayed.
View Article and Find Full Text PDFBackground: Renal oligohydramnios (ROH) describes an abnormally low volume of amniotic fluid (AF) during pregnancy. ROH is mostly caused by congenital fetal kidney anomalies. The ROH diagnosis frequently implies an increased risk of peri- and postnatal fetal mortality and morbidity.
View Article and Find Full Text PDFBackground: The coronavirus SARS-CoV-2 disease (COVID-19) pandemic affected lifestyles and resulted in significant weight gain in the general population. Its impact on children after kidney transplantation (KTx) is unknown.
Methods: We retrospectively evaluated body mass index (BMI) z-scores during the COVID-19 pandemic in 132 pediatric KTx patients, followed-up at three German hospitals.
Objective: : Arterial hypertension is a common complication in patients with autosomal recessive polycystic kidney disease (ARPKD), occurring in 33-75% of children when measured by office blood pressure (OBP). Ambulatory blood pressure monitoring (ABPM) is a superior tool for investigating blood pressure relative to OBP. The aim of our study was to investigate the prevalence and control of hypertension in children with ARPKD based on ABPM.
View Article and Find Full Text PDFArticle Synopsis
- Cystic kidney diseases like ARPKD and ADPKD often lead to high blood pressure, but studies on hypertension in children with RCAD syndrome from HNF1B gene mutations are limited.
- The study focused on examining high blood pressure prevalence and potential risk factors in children with genetically confirmed RCAD syndrome through various health assessments.
- Results indicated that 22% of the studied children had high office blood pressure, while 14% showed ambulatory hypertension, highlighting a notable hypertension presence in this specific population.
Using real-time SPECT/US fusion imaging, the localization of an uptake defect in DMSA scan could be identified unambiguously after being uncertain in ultrasound alone. Thereby, a localized functional loss, due to history of pyelonephritis, without scarring, but reduced cortical thickness could be verified. DMSA-SPECT/US primarily demonstrates its utility in depiction of renal pathologies and may be a descriptive tool in equivocal constellation of findings.
View Article and Find Full Text PDFAim: SPECT using Tc-99m-dimercaptosuccinic acid (DMSA-camSPECT) and ultrasound (US) are useful diagnostic modalities in pediatric nephrology. Former studies proved SPECT/US fusion to be a problem-solving tool for thyroid and sentinel lymph node imaging. The purpose of this study was to demonstrate the feasibility of real-time DMSA-camSPECT/US fusion in children and to evaluate the technical implementation.
View Article and Find Full Text PDFBackground: Febrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx.
Methods: Ninety-eight children (58 boys and 40 girls) ≤ 18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up.