Publications by authors named "Friederike Melching"
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Synopsis of recent research by authors named "Friederike Melching"
- Friederike Melching's research predominantly focuses on genetic heterogeneity in colorectal cancer, particularly examining how DNA copy number changes contribute to cancer progression and treatment outcomes.
- In her 2017 publication, she conducted a thorough analysis of DNA sequence and copy-number heterogeneity across primary tumours and matched metastases from colorectal cancer patients, revealing significant discordance in gene copy numbers.
- The study utilized targeted high-depth sequencing on 97 samples, identifying inter-tumour concordance for coding mutations, while highlighting the complexities and variations that exist within metastatic lesions, suggesting implications for personalized therapy approaches in cancer treatment.
