Publications by authors named "Friederike Grandke"
Article Synopsis
- MiRNAs are a type of non-coding RNA that regulates gene expression and are crucial for various biological pathways, with most studies focused on humans and mice.
- The miRNATissueAtlas has been developed to provide a comprehensive overview of miRNA expression across different tissues in both Homo sapiens and Mus musculus, now incorporating significantly more data and samples in its latest release.
- The 2025 update features expression data from 799 billion reads across 61,593 samples, an increase in the variety of tissues studied, and new calculations that enhance the understanding of tissue specificity and cross-species comparisons.
Non-thermal plasma, a partially ionized gas, holds significant potential for clinical applications, including wound-healing support, oral therapies, and anti-tumour treatments. While its applications showed promising outcomes, the underlying molecular mechanisms remain incompletely understood. We thus apply non-thermal plasma to mouse auricular skin and conducted non-coding RNA sequencing, as well as single-cell blood sequencing.
View Article and Find Full Text PDFThe molecular causes and mechanisms of neurodegenerative diseases remain poorly understood. A growing number of single-cell studies have implicated various neural, glial, and immune cell subtypes to affect the mammalian central nervous system in many age-related disorders. Integrating this body of transcriptomic evidence into a comprehensive and reproducible framework poses several computational challenges.
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