Publications by authors named "Fridolin Kielisch"
In mammals, X-chromosomal genes are expressed from a single copy since males (XY) possess a single X chromosome, while females (XX) undergo X inactivation. To compensate for this reduction in dosage compared with two active copies of autosomes, it has been proposed that genes from the active X chromosome exhibit dosage compensation. However, the existence and mechanisms of X-to-autosome dosage compensation are still under debate.
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- * Researchers used high-throughput mutagenesis and mathematical modeling to identify around 200 mutations that influence CD19 splicing, potentially leading to resistance against CART-19 treatment.
- * The study also discovered nearly 100 new splice isoforms that produce likely non-functional CD19 proteins and pinpointed key regulatory elements and RNA-binding proteins (like PTBP1 and SF3B4) that affect CD19 splicing, offering valuable insights for future predictive biomarkers for CART-19 therapy.
LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas in Drosophila, help localize the Vasa helicase to the germ granules and facilitate piRNA-mediated transposon silencing. The homologous proteins in mammals, TDRD5 and TDRD7, are required during spermiogenesis.
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