[Antigenic properties of influenza virus type A inactivated by ultraviolet irradiation].

The effect of ultraviolet irradiation (UVI) on influenza A virus was studied. UVI of influenza A virus purified by adsorption chromatography on porous glass (PG) was found to result in irreversible inactivation of virus. The rate of inactivation directly depended upon the degree of virus purification.

[Characteristics of the reactogenic and immunogenic properties of killed influence vaccine purified and concentrated by the method of adsorbed chromatography on silicate sorbents].

Reactogenic and immunogenic properties of killed influenza vaccine prepared of various strains of influenza virus by the method of sorption chromatography on sliciate sorbents were studied on small groups of volunteers; there proved to be a moderate reactogenic and a marked immunogenic activity of the experimental batches of the preparation. The dose, the concentration and the method of administration of the vaccine to obtain the immune response were determined. The indices of humoral and local immunity following a single vaccination were studied.